2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Apoptosis
  4. Purpurin 18

Purpurin 18, a derivative of chlorophyll and a type of dihydroporphyrin, is used to produce photosensitizers. Purpurin 18 photodynamic therapy can induce cell apoptosis and has anti-tumor activity.

For research use only. We do not sell to patients.

Purpurin 18 Chemical Structure

Purpurin 18 Chemical Structure

CAS No. : 25465-77-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
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10 mM * 1 mL in DMSO USD 165 In-stock
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50 mg USD 255 In-stock
100 mg USD 420 In-stock
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Based on 2 publication(s) in Google Scholar

Purpurin 18 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Purpurin 18, a derivative of chlorophyll and a type of dihydroporphyrin, is used to produce photosensitizers. Purpurin 18 photodynamic therapy can induce cell apoptosis and has anti-tumor activity[1][2].

In Vitro

Purpurin 18 (0-10 μM, 24 h) shows cytotoxicity to 4T1 cells under light reaction conditions, exhibiting strong photodynamic activity[1].
Purpurin 18 (0.5 μM, 4 h) PDT treatment induces apoptosis in 2D cultured 4T1 cells[1].
Purpurin 18 is mainly accumulated in the lysosomes of 4T1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purpurin 18 Related Antibodies

Cell Viability Assay[1]

Cell Line: 4T1
Concentration: 0, 0.25, 0.5, 1, 2, 4, 8, 10 μM
Incubation Time: 24 h
Result: Was non-cytotoxic at doses below 4 μM in the absence of light, but was cytotoxic when combined with light.

Apoptosis Analysis[1]

Cell Line: 4T1 (PTD)
Concentration: 0.5 μM
Incubation Time: 4 h
Result: Induced 50% cell apoptosis.
In Vivo

Purpurin 18 (0.625 mg/kg, intratumoral injection, single dose) has good photodynamic efficacy in mouse models. Purpurin 18 photodynamic therapy (PDT) inhibits tumor proliferation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Subcutaneous injection of 4T1 mouse model (PDT treatment)[1]
Dosage: 0.625 mg/kg; single dose
Administration: Intratumoral injection
Result: Had good photodynamic efficacy, did not affect body weight and major organ functions, and inhibited tumor proliferation.
Molecular Weight

564.63

Formula

C33H32N4O5
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C(O1)/C2=C([C@H]3CCC(O)=O)/N=C([C@H]3C)/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(CC)=C5C)=C\C6=C(C)C(C1=O)=C2N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (17.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7711 mL 8.8554 mL 17.7107 mL
5 mM 0.3542 mL 1.7711 mL 3.5421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (264 KB) HNMR (291 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7711 mL 8.8554 mL 17.7107 mL 44.2768 mL
5 mM 0.3542 mL 1.7711 mL 3.5421 mL 8.8554 mL
10 mM 0.1771 mL 0.8855 mL 1.7711 mL 4.4277 mL
15 mM 0.1181 mL 0.5904 mL 1.1807 mL 2.9518 mL
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Purpurin 18 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Purpurin 1825465-77-4Purpurin18Purpurin-18Reactive Oxygen SpeciesApoptosisPhotodynamic therapyapoptosis4T1Inhibitorinhibitorinhibit

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