2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. CDK Casein Kinase
  4. (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model.

For research use only. We do not sell to patients.

(R)-DRF053 dihydrochloride Chemical Structure

(R)-DRF053 dihydrochloride Chemical Structure

CAS No. : 1241675-76-2

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1 mg USD 175 In-stock
5 mg USD 435 In-stock
10 mg USD 740 In-stock
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(R)-DRF053 dihydrochloride Related Antibodies

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Description

(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].

IC50 & Target[1]

CK1

14 nM (IC50)

CDK1/cyclinB1

220 nM (IC50)

Cdk5/p25

80 nM (IC50)

Molecular Weight

490.43

Formula

C23H29Cl2N7O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 49.04 mg/mL (99.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0390 mL 10.1951 mL 20.3903 mL
5 mM 0.4078 mL 2.0390 mL 4.0781 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0390 mL 10.1951 mL 20.3903 mL 50.9757 mL
5 mM 0.4078 mL 2.0390 mL 4.0781 mL 10.1951 mL
10 mM 0.2039 mL 1.0195 mL 2.0390 mL 5.0976 mL
15 mM 0.1359 mL 0.6797 mL 1.3594 mL 3.3984 mL
20 mM 0.1020 mL 0.5098 mL 1.0195 mL 2.5488 mL
25 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0390 mL
30 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
40 mM 0.0510 mL 0.2549 mL 0.5098 mL 1.2744 mL
50 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0195 mL
60 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8496 mL
80 mM 0.0255 mL 0.1274 mL 0.2549 mL 0.6372 mL
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(R)-DRF053 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-DRF0531241675-76-2CDKCasein KinaseCyclin dependent kinaseCDK1/cyclin BCDK5/p25CK1Inhibitorinhibitorinhibit

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