2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. (R)-Irsenontrine

(R)-Irsenontrine  (Synonyms: (R)-E2027)

Cat. No.: HY-132821B Purity: 99.00% ee.: 100.00%
COA Handling Instructions

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(R)-Irsenontrine ((R)-E2027), the R-enantiomer of Irsenontrine (HY-132821), is a potent phosphodiesterase 9 (PDE9) inhibitor with an IC50 value of 0.041 μM. (R)-Irsenontrine can be used for the research of neurological diseases.

For research use only. We do not sell to patients.

(R)-Irsenontrine Chemical Structure

(R)-Irsenontrine Chemical Structure

CAS No. : 1429509-81-8

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1 mg USD 220 In-stock
5 mg USD 650 In-stock
10 mg USD 1050 In-stock
25 mg USD 2150 In-stock
50 mg USD 3450 In-stock
100 mg USD 5400 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Irsenontrine:

(R)-Irsenontrine Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

(R)-Irsenontrine ((R)-E2027), the R-enantiomer of Irsenontrine (HY-132821), is a potent phosphodiesterase 9 (PDE9) inhibitor with an IC50 value of 0.041 μM. (R)-Irsenontrine can be used for the research of neurological diseases[1].

IC50 & Target[1]

PDE9

0.041 μM (IC50)

Molecular Weight

390.44

Formula

C22H22N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N([C@]3([H])CCOC3)N=C2)C4=CC=C(C5=C(C)C=NC(OC)=C5C)C=C4N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (64.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5612 mL 12.8061 mL 25.6121 mL
5 mM 0.5122 mL 2.5612 mL 5.1224 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5612 mL 12.8061 mL 25.6121 mL 64.0303 mL
5 mM 0.5122 mL 2.5612 mL 5.1224 mL 12.8061 mL
10 mM 0.2561 mL 1.2806 mL 2.5612 mL 6.4030 mL
15 mM 0.1707 mL 0.8537 mL 1.7075 mL 4.2687 mL
20 mM 0.1281 mL 0.6403 mL 1.2806 mL 3.2015 mL
25 mM 0.1024 mL 0.5122 mL 1.0245 mL 2.5612 mL
30 mM 0.0854 mL 0.4269 mL 0.8537 mL 2.1343 mL
40 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
50 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2806 mL
60 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
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(R)-Irsenontrine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Irsenontrine1429509-81-8(R)-E2027Phosphodiesterase (PDE)phosphodiesteraseneurologicalAlzheimer’s diseaseParkinson’s diseasedementia with Lewy bodiesInhibitorinhibitorinhibit

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