(R)-Leucic acid (Synonyms: D-α-Hydroxyisocaproic acid)

Name: (R)-Leucic acid
Brand: MedChemExpress
SKU: HY-30216
Rating: 4.5 (1 reviews)

Cat. No.: HY-30216 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(R)-Leucic acid is an amino acid metabolite.

For research use only. We do not sell to patients.

(R)-Leucic acid Chemical Structure

CAS No. : 20312-37-2

Size	Price	Stock	Quantity

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 35	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 35	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Leucic acid:

(S)-Leucic acid In-stock
Leucic acid Get quote

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Description

(R)-Leucic acid is an amino acid metabolite^[1].

Molecular Weight

132.16

Formula

C₆H₁₂O₃

CAS No.

20312-37-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](O)CC(C)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (756.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (756.66 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5666 mL	37.8329 mL	75.6659 mL
5 mM	1.5133 mL	7.5666 mL	15.1332 mL
10 mM	0.7567 mL	3.7833 mL	7.5666 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (252.19 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) HNMR (136 KB)

Handling Instructions (2659 KB)

References

[1]. Buck, S. B., et al. Total Synthesis and Anti-Tubulin Activity of Epi-C3 Analogues of Cryptophycin-24. Journal of Medicinal Chemistry, 2004. 47(14), 3697–3699.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	7.5666 mL	37.8329 mL	75.6659 mL	189.1646 mL
	5 mM	1.5133 mL	7.5666 mL	15.1332 mL	37.8329 mL
	10 mM	0.7567 mL	3.7833 mL	7.5666 mL	18.9165 mL
	15 mM	0.5044 mL	2.5222 mL	5.0444 mL	12.6110 mL
	20 mM	0.3783 mL	1.8916 mL	3.7833 mL	9.4582 mL
	25 mM	0.3027 mL	1.5133 mL	3.0266 mL	7.5666 mL
	30 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL
	40 mM	0.1892 mL	0.9458 mL	1.8916 mL	4.7291 mL
	50 mM	0.1513 mL	0.7567 mL	1.5133 mL	3.7833 mL
	60 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	80 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	100 mM	0.0757 mL	0.3783 mL	0.7567 mL	1.8916 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(R)-Leucic acid Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Leucic acid20312-37-2D-α-Hydroxyisocaproic acidEndogenous MetaboliteaminoacidendogenousmetaboliteInhibitorinhibitorinhibit

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(R)-Leucic acid (Synonyms: D-α-Hydroxyisocaproic acid)

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Complete Stock Solution Preparation Table

(R)-Leucic acid Related Classifications

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