(Rac)-Calpain Inhibitor XII

Cat. No.: HY-116171 Purity: 99.04%: FAQs
Data Sheet SDS COA Handling Instructions

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(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, K_i=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, K_i=120 nM) and cathepsin B (K_i=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

For research use only. We do not sell to patients.

(Rac)-Calpain Inhibitor XII Chemical Structure

CAS No. : 181769-57-3

Size	Price	Stock	Quantity
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

482.57

Formula

C₂₆H₃₄N₄O₅

CAS No.

181769-57-3

Appearance

Solid

Color

White to yellow

SMILES

O=C(OCC1=CC=CC=C1)NC(C(NC(C(C(NCC2=NC=CC=C2)=O)=O)CCC)=O)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 16 mg/mL (33.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0722 mL	10.3612 mL	20.7224 mL
5 mM	0.4144 mL	2.0722 mL	4.1445 mL
10 mM	0.2072 mL	1.0361 mL	2.0722 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.04%

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Data Sheet (266 KB) SDS (252 KB)

COA (245 KB) HNMR (117 KB) RP-HPLC (227 KB)

Handling Instructions (2659 KB)

References

[1]. Z Li, et al. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem. 1996 Sep 27;39(20):4089-98. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0722 mL	10.3612 mL	20.7224 mL	51.8060 mL
	5 mM	0.4144 mL	2.0722 mL	4.1445 mL	10.3612 mL
	10 mM	0.2072 mL	1.0361 mL	2.0722 mL	5.1806 mL
	15 mM	0.1381 mL	0.6907 mL	1.3815 mL	3.4537 mL
	20 mM	0.1036 mL	0.5181 mL	1.0361 mL	2.5903 mL
	25 mM	0.0829 mL	0.4144 mL	0.8289 mL	2.0722 mL
	30 mM	0.0691 mL	0.3454 mL	0.6907 mL	1.7269 mL