(Rac)-Reparixin (Synonyms: (Rac)-Repertaxin; (Rac)-DF 1681Y)

Cat. No.: HY-15251A Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

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(Rac)-Reparixin is the isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC₅₀s of 1 and 100 nM, respectively.

For research use only. We do not sell to patients.

(Rac)-Reparixin Chemical Structure

CAS No. : 957407-64-6

Size	Price	Stock	Quantity
2 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-Reparixin:

Reparixin In-stock

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Description

Molecular Weight

283.39

Formula

C₁₄H₂₁NO₃S

CAS No.

957407-64-6

Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC(C(C)C1=CC=C(CC(C)C)C=C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (352.87 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5287 mL	17.6435 mL	35.2871 mL
5 mM	0.7057 mL	3.5287 mL	7.0574 mL
10 mM	0.3529 mL	1.7644 mL	3.5287 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (248 KB) HNMR (134 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo). 2013;68(3):391-4. [Content Brief]

[2]. Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. [Content Brief]

[3]. Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. [Content Brief]

[4]. Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201(2):814-820. [Content Brief]

[5]. Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002. [Content Brief]

[6]. Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54. [Content Brief]

[7]. Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(1):120-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5287 mL	17.6435 mL	35.2871 mL	88.2176 mL
	5 mM	0.7057 mL	3.5287 mL	7.0574 mL	17.6435 mL
	10 mM	0.3529 mL	1.7644 mL	3.5287 mL	8.8218 mL
	15 mM	0.2352 mL	1.1762 mL	2.3525 mL	5.8812 mL
	20 mM	0.1764 mL	0.8822 mL	1.7644 mL	4.4109 mL
	25 mM	0.1411 mL	0.7057 mL	1.4115 mL	3.5287 mL
	30 mM	0.1176 mL	0.5881 mL	1.1762 mL	2.9406 mL
	40 mM	0.0882 mL	0.4411 mL	0.8822 mL	2.2054 mL
	50 mM	0.0706 mL	0.3529 mL	0.7057 mL	1.7644 mL
	60 mM	0.0588 mL	0.2941 mL	0.5881 mL	1.4703 mL
	80 mM	0.0441 mL	0.2205 mL	0.4411 mL	1.1027 mL
	100 mM	0.0353 mL	0.1764 mL	0.3529 mL	0.8822 mL

(Rac)-Reparixin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Reparixin957407-64-6(Rac)-Repertaxin (Rac)-DF 1681YOthersInhibitorinhibitorinhibit

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(Rac)-Reparixin (Synonyms: (Rac)-Repertaxin; (Rac)-DF 1681Y)

Customer Review

Other Forms of (Rac)-Reparixin:

(Rac)-Reparixin Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

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Complete Stock Solution Preparation Table

(Rac)-Reparixin Related Classifications

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