Ramiprilat (Synonyms: HOE 498 diacid; Ramipril diacid)

Name: Ramiprilat
Brand: MedChemExpress
SKU: HY-A0115
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0115 Purity: 97.09%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a K_i value of 7 pM. Ramiprilat has acute antlhypertensive effect. Ramiprilat can be used for high blood pressure and heart failure research.

For research use only. We do not sell to patients.

Ramiprilat Chemical Structure

CAS No. : 87269-97-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

Ki: 7 pM (ACE)^[1]

In Vitro

Ramiprilat (0.1, 1 μM, 0-30 min) induces cyclic GMP increase in endothelial cells^[2].
Ramiprilat (0.3 μM, 15 min) elicits a significant nitric oxide release and an increase in prostaglandin I_{2 (PGI2) release in endothelial cells^[2].}

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ramiprilat (2 mg/kg, i.v., a single dose for 60 min) decreases the blood pressure of spontaneously hypertensive rats^[5].

Pharmacokinetic-pharmacodynamic parameters (mean±SD) for Ramiprilat after different IV and PO ramipril doses^[4]

Parameters	IV (0.05 mg/kg)	PO (0.40 mg/kg)	PO (0.80 mg/kg)
k₁₀ (1/h)	5.09	5.49	4.10
t_{1/2 k10} (h)	0.16 (0.09-0.31)	0.13 (0.10-0.16)	0.17 (0.10-0.27)
V_c (L/kg)	0.15
V_c/F (L/kg)		2.35	1.97
Cl (L/kg/h)	0.77
Cl/F (L/kg/h)		12.82	7.79
F (%)		6.52	9.08
K_d (nmol/L)	1.35	1.47	1.19
f_circ (%)	5.01	5.80	6.08
B_max (nmol/L)	109.46	79.31	91.72
P_max (nmol/L)	5.27	4.60	5.08
IC₅₀ (nmol/L)	1.05	1.07	0.88

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.46

Formula

C₂₁H₂₈N₂O₅

CAS No.

87269-97-4

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1C[C@@](CCC2)([H])[C@@]2([H])N1C([C@@H](N[C@H](C(O)=O)CCC3=CC=CC=C3)C)=O)O

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (321.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5743 mL	12.8713 mL	25.7427 mL
5 mM	0.5149 mL	2.5743 mL	5.1485 mL
10 mM	0.2574 mL	1.2871 mL	2.5743 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.45%

Select Batch:

Data Sheet (291 KB) SDS (393 KB)

COA (252 KB) HNMR (615 KB) RP-HPLC (140 KB) MS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research^[1]. [Content Brief]

[2]. Wiemer G, et al. Ramiprilat enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin. Hypertension. 1991 Oct;18(4):558-63. [Content Brief]

[3]. Wall TM, et al. Ramiprilat attenuates hypoxia/reoxygenation injury to cardiac myocytes via a bradykinin-dependent mechanism. Eur J Pharmacol. 1996 Jun 13;306(1-3):165-74. [Content Brief]

[4]. Serrano-Rodríguez JM, et al. Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat after intravenous and oral doses of ramipril in healthy horses. Vet J. 2016 Feb;208:38-43. [Content Brief]

[5]. Cachofeiro V, et al. Kinins, nitric oxide, and the hypotensive effect of captopril and ramiprilat in hypertension. Hypertension. 1992 Feb;19(2):138-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5743 mL	12.8713 mL	25.7427 mL	64.3567 mL
	5 mM	0.5149 mL	2.5743 mL	5.1485 mL	12.8713 mL
	10 mM	0.2574 mL	1.2871 mL	2.5743 mL	6.4357 mL
	15 mM	0.1716 mL	0.8581 mL	1.7162 mL	4.2904 mL
	20 mM	0.1287 mL	0.6436 mL	1.2871 mL	3.2178 mL
	25 mM	0.1030 mL	0.5149 mL	1.0297 mL	2.5743 mL
	30 mM	0.0858 mL	0.4290 mL	0.8581 mL	2.1452 mL
	40 mM	0.0644 mL	0.3218 mL	0.6436 mL	1.6089 mL
	50 mM	0.0515 mL	0.2574 mL	0.5149 mL	1.2871 mL
	60 mM	0.0429 mL	0.2145 mL	0.4290 mL	1.0726 mL
	80 mM	0.0322 mL	0.1609 mL	0.3218 mL	0.8045 mL
	100 mM	0.0257 mL	0.1287 mL	0.2574 mL	0.6436 mL

Ramiprilat Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramiprilat87269-97-4HOE 498 diacid Ramipril diacidDrug MetaboliteAngiotensin-converting Enzyme (ACE)Endogenous MetaboliteACE inhibitororally activehigh blood pressureheart failureInhibitorinhibitorinhibit

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Ramiprilat (Synonyms: HOE 498 diacid; Ramipril diacid)

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Ramiprilat Related Antibodies

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Complete Stock Solution Preparation Table

Ramiprilat Related Classifications

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