Aconitase 2/ACO2 Protein, Mouse (sf9, His-GST)

Aconitase 2 (ACO2) protein catalyzes the isomerization of citric acid to isocitrate through the intermediate aconitate, playing a crucial role in cellular metabolism. This enzyme activity is a key step in the tricarboxylic acid (TCA) cycle, a central pathway for energy production and generation of metabolic intermediates. Aconitase 2/ACO2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Aconitase 2/ACO2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Aconitase 2/ACO2 Protein, Mouse (sf9, His-GST) is 753 a.a., with molecular weight of ~100 kDa.

Aconitase 2 (ACO2) is an enzyme that plays a crucial role in the tricarboxylic acid (TCA) cycle by catalyzing the isomerization of citrate to isocitrate via the intermediate cis-aconitate. This reversible reaction is essential for the efficient metabolism of carbohydrates and the production of energy in the form of NADH. ACO2 acts as a key regulator in coordinating the flow of carbon through the TCA cycle, contributing to the generation of reducing equivalents and precursors for various biosynthetic pathways. The isomerization of citrate to isocitrate, facilitated by ACO2, represents a fundamental step in cellular energy production and metabolic homeostasis.

Mouse

Sf9 insect cells

N-His;N-GST

Q99KI0 (Q28-Q780)

11429  [NCBI]

Approximately 100 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.