Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution)

Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is 179 a.a., with molecular weight of ~21.0 kDa.

Cyclophilin B/PPIB Protein serves as a peptidyl-prolyl cis-trans isomerase (PPIase), actively engaging in the catalysis of cis-trans isomerization of proline imidic peptide bonds in oligopeptides, thus potentially contributing to the facilitation of protein folding. This enzymatic function underscores the protein's role in the dynamic process of promoting proper conformational changes in polypeptide chains, essential for their functional maturation. As a key player in the intricate realm of protein folding, Cyclophilin B/PPIB plays a crucial part in maintaining cellular protein homeostasis by facilitating the correct folding of nascent or misfolded polypeptides. The precise orchestration of these PPIase activities underscores the protein's importance in cellular physiology, warranting further exploration to unveil the specific molecular mechanisms and cellular pathways through which Cyclophilin B/PPIB contributes to protein folding dynamics.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

P23284 (D34-A212)

5479  [NCBI]

DEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFA

Approximately 21.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 6% Sucrose, 4% Mannitol, 50 mM NaCl, 0.05% Tween 80, pH 6.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.