2. Gene
  3. PPIB - peptidylprolyl isomerase B Gene

PPIB - peptidylprolyl isomerase B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OI9; CYPB; SCYLP; CYP-S1; HEL-S-39

Gene ID: 5479 | Gene type: protein coding

About PPIB

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,155,817-64,163,022 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 22 paralogues and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 295.6), placenta (RPKM 241.5) and 25 other tissues.

Summary

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

PPIB Products(1)

mRNA Protein Name
NM_000942.5 NP_000933.1 peptidyl-prolyl cis-trans isomerase B precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase binding IPI
IPI: Inferred from physical interaction
15989969 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
20676357 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15095401 GOA
Biological Process GO Annotation Evidence Reference Source
involved in bone development IMP
IMP: Inferred from mutant phenotype
20089953 GOA
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
22665516 GOA
NOT involved in chaperone-mediated protein folding IMP
IMP: Inferred from mutant phenotype
20089953 GOA
involved in neutrophil chemotaxis IDA
IDA: Inferred from direct assay
11688976 GOA
involved in positive regulation by host of viral genome replication IMP
IMP: Inferred from mutant phenotype
15989969 GOA
involved in positive regulation by host of viral process IMP
IMP: Inferred from mutant phenotype
15989969 GOA
involved in positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
20089953 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20089953 GOA
NOT involved in regulation of post-translational protein modification IMP
IMP: Inferred from mutant phenotype
20089953 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
20089953 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15989969 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIB Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (49 - 203)

  • 0
  • 100
  • 200
  • 216 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase B

PPIase B

PPIB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPIB P23284 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
PPIB P23284 PDIA4 Homo sapiens P13667
NMR
22665516
Intra
PPIB P23284 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32814053
Intra
PPIB P23284 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32814053
Intra
PPIB P23284 WWOX Homo sapiens Q9NZC7-5
Y2H Pooling
32814053
Intra
PPIB P23284 CENPV Homo sapiens Q7Z7K6
Validated Y2H
32814053
Intra
PPIB P23284 CENPV Homo sapiens Q7Z7K6
Y2H Pooling
32814053
Intra
PPIB P23284 CENPV Homo sapiens Q7Z7K6
Y2H Array
32814053
Intra
PPIB P23284 a0a087wzy1_human Homo sapiens A0A087WZY1
Y2H Array
32296183
Intra
PPIB P23284 a0a087wzy1_human Homo sapiens A0A087WZY1
Y2H Prey Pooling
32296183
Intra
PPIB P23284 TRDN Homo sapiens Q13061-2
Y2H Array
32296183
Intra
PPIB P23284 TRDN Homo sapiens Q13061-2
Y2H Prey Pooling
32296183
Intra
PPIB P23284 TRDN Homo sapiens Q13061-2
Validated Y2H
32296183
Intra
PPIB P23284 LHX5 Homo sapiens Q9H2C1
Validated Y2H
32814053
Intra
PPIB P23284 LHX5 Homo sapiens Q9H2C1
Y2H Array
32814053
Intra
PPIB P23284 LHX5 Homo sapiens Q9H2C1
Y2H Pooling
32814053
Intra
PPIB P23284 RMND1 Homo sapiens Q9NWS8-3
Validated Y2H
32814053
Intra
PPIB P23284 RMND1 Homo sapiens Q9NWS8-3
Y2H Array
32814053
Intra
PPIB P23284 RMND1 Homo sapiens Q9NWS8-3
Y2H Pooling
32814053
Intra
PPIB P23284 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
PPIB P23284 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
PPIB P23284 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
PPIB P23284 HSPA6 Homo sapiens P17066
Y2H Prey Pooling
32296183
Intra
PPIB P23284 HSPA6 Homo sapiens P17066
Y2H Array
32296183
Intra
PPIB P23284 STIM1 Homo sapiens Q13586
Y2H Array
32814053
Intra
PPIB P23284 STIM1 Homo sapiens Q13586
Validated Y2H
32814053
Intra
PPIB P23284 STIM1 Homo sapiens Q13586
Y2H Pooling
32814053
Intra
PPIB P23284 PEX19 Homo sapiens P40855
Y2H Prey Pooling
32296183
Intra
PPIB P23284 PEX19 Homo sapiens P40855
Y2H Prey Pooling
25416956
Intra
PPIB P23284 PEX19 Homo sapiens P40855
Validated Y2H
25416956
Intra
PPIB P23284 PEX19 Homo sapiens P40855
Validated Y2H
32296183
Intra
PPIB P23284 PEX19 Homo sapiens P40855
Y2H Array
32296183
Intra
PPIB P23284 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
25416956
Intra
PPIB P23284 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
PPIB P23284 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
PPIB P23284 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
PPIB P23284 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
PPIB P23284 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra
PPIB P23284 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra
PPIB P23284 KLF12 Homo sapiens Q9Y4X4
Validated Y2H
32814053
Intra
PPIB P23284 KLF12 Homo sapiens Q9Y4X4
Y2H Array
32814053
Intra
PPIB P23284 KLF12 Homo sapiens Q9Y4X4
Y2H Pooling
32814053
Intra
PPIB P23284 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
PPIB P23284 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
PPIB P23284 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross
PPIB P23284 Q9WMX2-PRO_0000037552 Hepatitis C virus Q9WMX2-PRO_0000037552
Anti Bait CoIP
15989969
Cross
PPIB P23284 Q9WMX2-PRO_0000037552 Hepatitis C virus Q9WMX2-PRO_0000037552
Pull Down
15989969
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIB Proteins

Cat. No. Product Name Accession Purity
HY-P70011 Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) P23284 (D34-A212) ≥95%
HY-P70011A Cyclophilin B/PPIB Protein, Human (HEK293, His) P23284 (D34-A212) ≥95%

PPIB Antibodies

Cat. No. Product Name Application Reactivity
HY-P80638 Cyclophilin B Antibody (YA787) WB, IHC-P Human, Rat, Mouse

Related Diseases

Diseases Alias
Osteogenesis Imperfecta, Type Ix

Osteogenesis Imperfecta Type 9

Osteogenesis Imperfecta Type Ix

OI9

Oi Type Ix

Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen

Oi, Type Ix

Oi 9

Osteogenesis Imperfecta 9

Oi-Ix
Osteogenesis Imperfecta, Type Ii

Vrolik Type Of Osteogenesis Imperfecta

Osteogenesis Imperfecta Type 2

OI2

Oi, Type Ii

Osteogenesis Imperfecta Congenita

Oic

Osteogenesis Imperfecta Type Ii

Lethal Osteogenesis Imperfecta

Oi Type 2

Osteogenesis Imperfecta Congenita Perinatal Lethal Form

Osteogenesis Imperfecta Congenita, Perinatal Lethal Form

Perinatal Lethal Osteogenesis Imperfecta Congenita

Perinatally Lethal Oi

Osteogenesis Imperfecta 2

Oi-Ii

Oi-Iia

Oi Type Iia

Osteogenesis Imperfecta Type Iia

Osteogenesis Imperfecta Type Ii Autosomal Dominant

Oi Type Ii

Osteogenesis Imperfecta, Dominant Perinatal Lethal
Osteogenesis Imperfecta, Type Iv

Osteogenesis Imperfecta Type 4

Osteogenesis Imperfecta Type Iv

OI4

Oi, Type Iv

Osteogenesis Imperfecta With Normal Sclerae

Oi Type Iv

Oi Type 4

Osteogenesis Imperfecta With Normal Sclera

Common Variable Oi With Normal Sclerae

Osteogenesis Imperfecta 4

Oi-Iv
Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii

OI3

Oi, Type Iii

Osteogenesis Imperfecta Type 3

Oi Type Iii

Oi Type 3

Progressive Deforming Osteogenesis Imperfecta

Severe Osteogenesis Imperfecta

Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

Progressively Deforming Oi

Osteogenesis Imperfecta 3

Oi-Iii

Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness
Dentinogenesis Imperfecta

Hereditary Opalescent Dentin

Dentinogenesis Imperfecta Without Osteogenesis Imperfecta

Dgi

Capdepont Teeth

Dgi Without Oi

Di

Non-Syndromic Dgi

Non-Syndromic Dentinogenesis Imperfecta

Opalescent Teeth Without Oi

Opalescent Teeth Without Osteogenesis Imperfecta

Opalescent Dentin
Osteogenesis Imperfecta, Type Vii

Osteogenesis Imperfecta Type 7

Osteogenesis Imperfecta Type Vii

OI7

Oi Type Vii

Oi, Type Vii

Osteogenesis Imperfecta, Type Iib, Formerly

Oi2b, Formerly

Oi Type 7

Osteogenesis Imperfecta 7

Oi2b

Oi-Iib

Oi Type Iib

Oi-Vii

Osteogenesis Imperfecta Perinatal Lethal Autosomal Recessive

Osteogenesis Imperfecta Type Ii Autosomal Recessive

Osteogenesis Imperfecta Type Iib
Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots
Joubert Syndrome 8

JBTS8

Joubert Syndrome, Type 8
Bruck Syndrome

Osteogenesis Imperfecta With Congenital Joint Contractures

Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome
Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy

Tam

Myopathy With Tubular Aggregates

TAM1

Myopathy, Tubular Aggregate

Tubular Aggregate Myopathy 1
Ehlers-Danlos Syndrome, Classic Type, 1

Ehlers-Danlos Syndrome, Type I

EDSCL1

Ehlers-Danlos Syndrome Classic Type 1

Ehlers-Danlos Syndrome Type 1

Ehlers-Danlos Syndrome, Type I, Formerly

Eds1, Formerly

Ehlers-Danlos Syndrome, Severe Classic Type, Formerly

Eds I, Formerly

Ehlers-Danlos Syndrome, Gravis Type, Formerly

Ehlers-Danlos Syndrome, Type 1

Type I Ehlers-Danlos Syndrome

Eds1

Eds I

Ehlers-Danlos Syndrome, Gravis Type

Ehlers-Danlos Syndrome, Severe Classic Type

Ehlers-Danlos Syndrome 1

Ehlers-Danlos, Classic Syndrome, Type 1

Ehlers-Danlos Syndrome Type 2
Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv
Bone Development Disease
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10947 PPIB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPIB VGNC VGNC:33195
Macaca mulatta PPIB VGNC VGNC:99227
Mus musculus PPIB MGD MGI:97750
Canis familiaris PPIB VGNC VGNC:44849
Felis catus PPIB VGNC VGNC:104577
Rattus norvegicus PPIB RGD RGD:620312
Others PPIB NCBI