2. Gene
  3. IL13RA1 - interleukin 13 receptor subunit alpha 1 Gene

IL13RA1 - interleukin 13 receptor subunit alpha 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NR4; CT19; CD213A1; IL-13Ra

Gene ID: 3597 | Gene type: protein coding

About IL13RA1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,727,606-118,805,228 (from NCBI)

This gene has 4 transcripts (splice variants), 418 orthologues and 23 paralogues. Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase Tyk2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

IL13RA1 Products(1)

mRNA Protein Name
NM_001560.3 NP_001551.1 interleukin-13 receptor subunit alpha-1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12935900 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL13RA1 Protein Structure

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (128 - 223)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

interleukin-13 receptor subunit alpha-1

CD213a1 antigen

IL13RA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IL13RA1 P78552 IL13 Homo sapiens P35225
ITC
18243101
Intra
IL13RA1 P78552 IL13 Homo sapiens P35225
X-Ray Diffraction
18243101
Intra
IL13RA1 P78552 IL4 Homo sapiens P05112
ITC
18243101
Intra
IL13RA1 P78552 IL4 Homo sapiens P05112
X-Ray Diffraction
18243101
Intra
IL13RA1 P78552 TRAF3IP1 Homo sapiens Q8TDR0
Y3H
12935900
Intra
IL13RA1 P78552 TRAF3IP1 Homo sapiens Q8TDR0
Anti Tag CoIP
12935900
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL13RA1 Proteins

Cat. No. Product Name Accession Purity
HY-P72594 IL-13R alpha 1 Protein, Human (HEK293, His) P78552-1 (G22-T343) ≥95%
HY-P78163 IL-13R alpha 1 Protein, Human (Biotinylated, HEK293, His-Avi) P78552-1 (A27-T343) ≥95%

IL13RA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81632 IL-13RA1 Antibody (YA1377) FC, ELISA Human
HY-P81879 IL-13 Receptor alpha 1 Antibody (YA1624) WB Human

Related Diseases

Diseases Alias
Monofixation Syndrome
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Syndromic X-Linked Intellectual Disability Cabezas Type

Cabezas Syndrome

Syndromic X-Linked Mental Retardation 15

Mental Retardation, X-Linked, Syndromic 15

Mrss

Mrxs15

Mrxsc

X-Linked Mental Retardation With Short Stature

X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait

Mental Retardation, X-Linked, With Short Stature

Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99870 Eblasakimab ≥99.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL13RA1 RGD RGD:628741
Mus musculus IL13RA1 MGD MGI:105052
Bos taurus IL13RA1 VGNC VGNC:55053
Felis catus IL13RA1 VGNC VGNC:67758
Canis familiaris IL13RA1 VGNC VGNC:41937
Macaca fascicularis IL13RA1 NCBI NCBI:102135058
Others IL13RA1 NCBI