2. Cell Cycle/DNA Damage Anti-infection Apoptosis
  3. Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis
  4. rel-Zotatifin

rel-Zotatifin  (Synonyms: rel-eFT226)

Cat. No.: HY-112163A Purity: 97.32%
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rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex.

For research use only. We do not sell to patients.

rel-Zotatifin Chemical Structure

rel-Zotatifin Chemical Structure

CAS No. : 2098191-54-7

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5 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

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rel-Zotatifin Related Antibodies

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Description

rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1].

Molecular Weight

487.56

Formula

C28H29N3O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=CC=C([C@@]2(O3)[C@@](C4=C3C=C(OC)N=C4OC)(O)[C@H](O)[C@H](CN(C)C)[C@H]2C5=CC=CC=C5)C=C1.[Relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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rel-Zotatifin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

rel-Zotatifin2098191-54-7rel-eFT226Eukaryotic Initiation Factor (eIF)SARS-CoVApoptosisSARS coronavirusInhibitorinhibitorinhibit

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