2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Reversin 121

Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Reversin 121 Chemical Structure

Reversin 121 Chemical Structure

CAS No. : 174630-04-7

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1 mg USD 60 In-stock
5 mg USD 195 In-stock
10 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Reversin 121 Related Antibodies

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Description

Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers[1][2].

IC50 & Target

P-glycoprotein[1]
Cellular Effect
Cell Line Type Value Description References
NIH3T3 IC50
1.41 μM
Compound: 1
Inhibition of human MDR1 expressed in mouse NIH3T3 cells assessed as inhibition of drug efflux by flow cytometry
Inhibition of human MDR1 expressed in mouse NIH3T3 cells assessed as inhibition of drug efflux by flow cytometry
[PMID: 20731360]
In Vitro

Reversin 121 (12 μg/mL) (with gemcitabine (HY-17026)) reduces the proportions of tumor cells positive for MDR proteins in Panc1 cell[1].
Reversin 121 (5 μM) reverses the resistance against paclitaxel in paclitaxel-resistant NCI-H460 cell[2].
Reversin 121 (10 μM, 48 h) inhibits T cell proliferation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reversin 121 Related Antibodies
In Vivo

Reversin 121 (2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day, i.p.) decreases tumor size and prevalence of metastases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Orthotopic pancreatic carcinoma mouse model[1].
Dosage: 2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day
Administration: Intraperitoneal injection (i.p.), 5 days a week
Result: Decreased in MRP3-positive cells.
Molecular Weight

641.75

Formula

C34H47N3O9
CAS No.
Appearance

Oil

Color

Colorless to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Pure form -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (155.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5582 mL 7.7912 mL 15.5824 mL
5 mM 0.3116 mL 1.5582 mL 3.1165 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5582 mL 7.7912 mL 15.5824 mL 38.9560 mL
5 mM 0.3116 mL 1.5582 mL 3.1165 mL 7.7912 mL
10 mM 0.1558 mL 0.7791 mL 1.5582 mL 3.8956 mL
15 mM 0.1039 mL 0.5194 mL 1.0388 mL 2.5971 mL
20 mM 0.0779 mL 0.3896 mL 0.7791 mL 1.9478 mL
25 mM 0.0623 mL 0.3116 mL 0.6233 mL 1.5582 mL
30 mM 0.0519 mL 0.2597 mL 0.5194 mL 1.2985 mL
40 mM 0.0390 mL 0.1948 mL 0.3896 mL 0.9739 mL
50 mM 0.0312 mL 0.1558 mL 0.3116 mL 0.7791 mL
60 mM 0.0260 mL 0.1299 mL 0.2597 mL 0.6493 mL
80 mM 0.0195 mL 0.0974 mL 0.1948 mL 0.4869 mL
100 mM 0.0156 mL 0.0779 mL 0.1558 mL 0.3896 mL
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Reversin 121 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reversin 121174630-04-7Reversin121Reversin-121P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Multidrug resistancecancerT cellInhibitorinhibitorinhibit

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