2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Rezivertinib analogue 1

Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer.

For research use only. We do not sell to patients.

Rezivertinib analogue 1 Chemical Structure

Rezivertinib analogue 1 Chemical Structure

CAS No. : 2227103-37-7

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Rezivertinib analogue 1 Related Antibodies

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Description

Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer[1].

Molecular Weight

487.60

Formula

C27H33N7O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C)NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCN(C)C)C)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0509 mL 10.2543 mL 20.5086 mL
5 mM 0.4102 mL 2.0509 mL 4.1017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0509 mL 10.2543 mL 20.5086 mL 51.2715 mL
5 mM 0.4102 mL 2.0509 mL 4.1017 mL 10.2543 mL
10 mM 0.2051 mL 1.0254 mL 2.0509 mL 5.1272 mL
15 mM 0.1367 mL 0.6836 mL 1.3672 mL 3.4181 mL
20 mM 0.1025 mL 0.5127 mL 1.0254 mL 2.5636 mL
25 mM 0.0820 mL 0.4102 mL 0.8203 mL 2.0509 mL
30 mM 0.0684 mL 0.3418 mL 0.6836 mL 1.7091 mL
40 mM 0.0513 mL 0.2564 mL 0.5127 mL 1.2818 mL
50 mM 0.0410 mL 0.2051 mL 0.4102 mL 1.0254 mL
60 mM 0.0342 mL 0.1709 mL 0.3418 mL 0.8545 mL
80 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6409 mL
100 mM 0.0205 mL 0.1025 mL 0.2051 mL 0.5127 mL
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Rezivertinib analogue 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rezivertinib analogue 12227103-37-7Rezivertinib analogue1Rezivertinib analogue-1Drug MetaboliteImpurityosimertinib mesylatenon-small cell lung cancerInhibitorinhibitorinhibit

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