2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton MAPK/ERK Pathway PI3K/Akt/mTOR
  3. ROCK ERK GSK-3
  4. ROCK-IN-5

ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research.

For research use only. We do not sell to patients.

ROCK-IN-5 Chemical Structure

ROCK-IN-5 Chemical Structure

CAS No. : 692870-25-0

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Customer Review

Based on 1 publication(s) in Google Scholar

ROCK-IN-5 Related Antibodies

Top Publications Citing Use of Products

View All ROCK Isoform Specific Products:

View All Isoforms
ROCK ROCK1 ROCK2

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All GSK-3 Isoform Specific Products:

View All Isoforms
GSK-3 GSK-3α GSK-3β

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research[1].

Molecular Weight

347.79

Formula

C16H11ClFN3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=C(F)C=CC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (35.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8753 mL 14.3765 mL 28.7530 mL
5 mM 0.5751 mL 2.8753 mL 5.7506 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8753 mL 14.3765 mL 28.7530 mL 71.8825 mL
5 mM 0.5751 mL 2.8753 mL 5.7506 mL 14.3765 mL
10 mM 0.2875 mL 1.4376 mL 2.8753 mL 7.1882 mL
15 mM 0.1917 mL 0.9584 mL 1.9169 mL 4.7922 mL
20 mM 0.1438 mL 0.7188 mL 1.4376 mL 3.5941 mL
25 mM 0.1150 mL 0.5751 mL 1.1501 mL 2.8753 mL
30 mM 0.0958 mL 0.4792 mL 0.9584 mL 2.3961 mL
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ROCK-IN-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK-IN-5692870-25-0ROCKERKGSK-3Rho-associated protein kinaseRho-associated kinaseRho-kinaseROKExtracellular signal regulated kinasesGlycogen synthase kinase-3Glycogen synthase kinase 3GSKAGCproliferativecardiacneurodegenerative diseasesInhibitorinhibitorinhibit

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