RP-182-PEG3-K(palmitic acid)

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RP-182-PEG3-K palmitic acid (Compound 1a) inhibits CD206^high M2-like macrophage (IC₅₀ of 3.2 µM) and induces phagocytosis. RP-182-PEG3-K palmitic acid exhibits antitumor efficacy in mouse B16 melanoma allografts.

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RP-182-PEG3-K(palmitic acid) Chemical Structure

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Description	RP-182-PEG3-K palmitic acid (Compound 1a) inhibits CD206^high M2-like macrophage (IC₅₀ of 3.2 µM) and induces phagocytosis. RP-182-PEG3-K palmitic acid exhibits antitumor efficacy in mouse B16 melanoma allografts^[1].
Molecular Weight	1929.48
Formula	C₉₉H₁₆₁N₂₃O₁₆
SMILES	C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CC=CC=C1)=O)CCCNC(N)=N)=O)CCCCN)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCCOCCOCCOCC(N[C@@H](CCCCNC(CCCCCCCCCCCCCCC)=O)C(N)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)=O)CC4=CC=CC=C4)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Singh SS, et al., Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity. Mol Cancer Ther. 2024 Aug 30. [Content Brief]