2. Membrane Transporter/Ion Channel
  3. Ferroportin
  4. Rusfertide

Rusfertide  (Synonyms: PTG-300)

Cat. No.: HY-P10272 Purity: 99.79%
SDS COA Handling Instructions

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Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Rusfertide Chemical Structure

Rusfertide Chemical Structure

CAS No. : 1628323-80-7

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Based on 1 publication(s) in Google Scholar

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Description

Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis[1][2].

In Vivo

Rusfertide limits the iron toxicity in red blood cells (RBCs) (1 mg/kg, s.c., once every two days, for 49 days) and transferrin-saturation (2.5 mg/kg, s.c., once every two days, for 2 weeks), improves oxygen carrying capacity of RBCs, attenuates the anemia and iron deposition in mice models for β-thalassemia and hereditary hemochromatosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hbbth3/+ mice model for β-thalassemia and hereditary hemochromatosis[1]
Dosage: 1 and 2.5 mg/kg
Administration: s.c., once every two days, for 49 days (1 mg/kg); or for 2 weeks (2.5 mg/kg)
Result: Improved the survival rate of RBCs in β-thalassemia model.
Reduced transferrin-saturation and iron deposition.
Molecular Weight

2441.95

Formula

C114H181N27O28S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Asp(N-(3-methyl-1-oxobutyl))}-Thr-His-Phe-Pro-Cys-Ile-{Lys(γGlu-C16 acid)}-Phe-Glu-Pro-Arg-Ser-Lys-Gly-Cys-Lys-NH2 (disulfide bridge: Cys6-Cys16)
Sequence Shortening

{Asp(N-(3-methyl-1-oxobutyl))}-THFPCI-{Lys(γGlu-C16 acid)}-FEPRSKGCK-NH2 (disulfide bridge: Cys6-Cys16)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (40.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4095 mL 2.0475 mL 4.0951 mL
5 mM 0.0819 mL 0.4095 mL 0.8190 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

SDS (252 KB)

COA (259 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4095 mL 2.0475 mL 4.0951 mL 10.2377 mL
5 mM 0.0819 mL 0.4095 mL 0.8190 mL 2.0475 mL
10 mM 0.0410 mL 0.2048 mL 0.4095 mL 1.0238 mL
15 mM 0.0273 mL 0.1365 mL 0.2730 mL 0.6825 mL
20 mM 0.0205 mL 0.1024 mL 0.2048 mL 0.5119 mL
25 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.4095 mL
30 mM 0.0137 mL 0.0683 mL 0.1365 mL 0.3413 mL
40 mM 0.0102 mL 0.0512 mL 0.1024 mL 0.2559 mL
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Rusfertide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rusfertide1628323-80-7PTG-300PTG300PTG 300FerroportinIron-regulated Transporter 1polycythemia veraβ-thalassemia and hereditary hemochromatosisInhibitorinhibitorinhibit

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