2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Ruzotolimod

Ruzotolimod  (Synonyms: RO7020531; RG7854)

Cat. No.: HY-145592 Purity: 99.92%
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Ruzotolimod is an orally active TLR7 agonist. Ruzotolimod is an immunomodulatory agent that can be used to study HBV, COVID-19, or SARS-CoV-2 infection.

For research use only. We do not sell to patients.

Ruzotolimod Chemical Structure

Ruzotolimod Chemical Structure

CAS No. : 1948241-60-8

Size Price Stock Quantity
5 mg USD 432 In-stock
10 mg USD 690 In-stock
25 mg USD 1385 In-stock
50 mg USD 1950 In-stock
100 mg USD 2730 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Ruzotolimod Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

Ruzotolimod is an orally active TLR7 agonist. Ruzotolimod is an immunomodulatory agent that can be used to study HBV, COVID-19, or SARS-CoV-2 infection[1][2].

IC50 & Target

TLR7[1]
Molecular Weight

354.38

Formula

C14H18N4O5S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N([C@]([C@@H](C2)O)([H])O[C@]2([H])[C@H](CC)OC(C)=O)C3=NC(N)=NC=C3S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (352.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8218 mL 14.1091 mL 28.2183 mL
5 mM 0.5644 mL 2.8218 mL 5.6437 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8218 mL 14.1091 mL 28.2183 mL 70.5457 mL
5 mM 0.5644 mL 2.8218 mL 5.6437 mL 14.1091 mL
10 mM 0.2822 mL 1.4109 mL 2.8218 mL 7.0546 mL
15 mM 0.1881 mL 0.9406 mL 1.8812 mL 4.7030 mL
20 mM 0.1411 mL 0.7055 mL 1.4109 mL 3.5273 mL
25 mM 0.1129 mL 0.5644 mL 1.1287 mL 2.8218 mL
30 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3515 mL
40 mM 0.0705 mL 0.3527 mL 0.7055 mL 1.7636 mL
50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4109 mL
60 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1758 mL
80 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
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Ruzotolimod Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ruzotolimod1948241-60-8RO7020531 RG7854RO 7020531RO-7020531RG7854RG 7854RG-7854Toll-like Receptor (TLR)TLR7HBVCOVID-19SARS-CoV-2Inhibitorinhibitorinhibit

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