2. Metabolic Enzyme/Protease Anti-infection
  3. Mitochondrial Metabolism Parasite
  4. RYL-552

RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor.

For research use only. We do not sell to patients.

RYL-552 Chemical Structure

RYL-552 Chemical Structure

CAS No. : 1801444-56-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 429 In-stock
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5 mg USD 390 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

RYL-552 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor[1].

Cellular Effect
Cell Line Type Value Description References
Huh7.5.1 CC50
> 10 μM
Compound: 2; RYL-552
Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay
[PMID: 30938999]
Molecular Weight

427.39

Formula

C24H17F4NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C)=C(NC2=C1C(F)=CC=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3398 mL 11.6989 mL 23.3978 mL
5 mM 0.4680 mL 2.3398 mL 4.6796 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.63%

SDS (251 KB)

COA (245 KB) HNMR (121 KB) RP-HPLC (184 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3398 mL 11.6989 mL 23.3978 mL 58.4946 mL
5 mM 0.4680 mL 2.3398 mL 4.6796 mL 11.6989 mL
10 mM 0.2340 mL 1.1699 mL 2.3398 mL 5.8495 mL
15 mM 0.1560 mL 0.7799 mL 1.5599 mL 3.8996 mL
20 mM 0.1170 mL 0.5849 mL 1.1699 mL 2.9247 mL
25 mM 0.0936 mL 0.4680 mL 0.9359 mL 2.3398 mL
30 mM 0.0780 mL 0.3900 mL 0.7799 mL 1.9498 mL
40 mM 0.0585 mL 0.2925 mL 0.5849 mL 1.4624 mL
50 mM 0.0468 mL 0.2340 mL 0.4680 mL 1.1699 mL
60 mM 0.0390 mL 0.1950 mL 0.3900 mL 0.9749 mL
80 mM 0.0292 mL 0.1462 mL 0.2925 mL 0.7312 mL
100 mM 0.0234 mL 0.1170 mL 0.2340 mL 0.5849 mL
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RYL-552 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RYL-5521801444-56-3RYL552RYL 552Mitochondrial MetabolismParasitequinone oxidoreductasePfNDH2 inhibtorquinolone compounETCInhibitorinhibitorinhibit

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