2. GPCR/G Protein MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. Ras PERK
  4. (S)-JDQ-443

(S)-JDQ-443  (Synonyms: (S)-NVP-JDQ443)

Cat. No.: HY-139612A Purity: 99.32% ee.: 100%
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(S)-JDQ-443 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity.

For research use only. We do not sell to patients.

(S)-JDQ-443 Chemical Structure

(S)-JDQ-443 Chemical Structure

CAS No. : 2653994-10-4

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10 mg USD 720 In-stock
25 mg USD 1400 In-stock
50 mg USD 2240 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

(S)-JDQ-443 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity[1][2].

Cellular Effect
Cell Line Type Value Description References
NCI-H1437 GI50
4.4 μM
Compound: 21; JDQ443
Antiproliferative activity against human NCI-H1437 cells by resazurin assay
Antiproliferative activity against human NCI-H1437 cells by resazurin assay
[PMID: 36399068]
NCI-H358 GI50
0.018 μM
Compound: 21; JDQ443
Antiproliferative activity against human NCI-H358 cells by resazurin assay
Antiproliferative activity against human NCI-H358 cells by resazurin assay
[PMID: 36399068]
In Vitro

JDQ-443 promotes dose-dependent reductions of phosphorylated ERK (pERK) levels and the proliferation of the KRASG12C-mutated cell lines NCI-H358 and NCI-H2122, with IC50 values of 0.018 and 0.063 μM, respectively[2].
JDQ443 covalently and selectively binds and inhibits GDP-bound KRASG12C with low reversible binding affinity to the RAS switch II pocket, and also inhibits proliferation of KRASG12C-mutated and KRAS G12C/H95, G12C/R68S, and G12C/Y96 double-mutant cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-JDQ-443 Related Antibodies
In Vivo

JDQ443 (10-100 mg/kg, Orally, daily for 14 days) shows antitumor activity and inhibits the growth of tumor in a dose-dependent manner in KRAS G12C-mutated CDX models[2].
JDQ443 (Orally, 100 mg/kg, daily (JDQ443) + 7.5 mg/kg, twice daily (TNO155), for 36 days) shows greater cell growth inhibition or cell killing compared with single-agent JDQ443 when combined with TNO155[2].
JDQ443 generates categorical antitumor responses in PDX models of NSCLC and colorectal tumors that are improved by combination treatment with other agents[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

558.10

Formula

C29H28ClN7OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C=C)N1CC2(C1)CC(N3N=C(C4=CC=C5C(C=NN5C)=C4)[C@@]([C@@]6=C(Cl)C(C)=CC7=C6C=NN7)=C3C)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (179.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7918 mL 8.9590 mL 17.9179 mL
5 mM 0.3584 mL 1.7918 mL 3.5836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7918 mL 8.9590 mL 17.9179 mL 44.7948 mL
5 mM 0.3584 mL 1.7918 mL 3.5836 mL 8.9590 mL
10 mM 0.1792 mL 0.8959 mL 1.7918 mL 4.4795 mL
15 mM 0.1195 mL 0.5973 mL 1.1945 mL 2.9863 mL
20 mM 0.0896 mL 0.4479 mL 0.8959 mL 2.2397 mL
25 mM 0.0717 mL 0.3584 mL 0.7167 mL 1.7918 mL
30 mM 0.0597 mL 0.2986 mL 0.5973 mL 1.4932 mL
40 mM 0.0448 mL 0.2240 mL 0.4479 mL 1.1199 mL
50 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8959 mL
60 mM 0.0299 mL 0.1493 mL 0.2986 mL 0.7466 mL
80 mM 0.0224 mL 0.1120 mL 0.2240 mL 0.5599 mL
100 mM 0.0179 mL 0.0896 mL 0.1792 mL 0.4479 mL
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(S)-JDQ-443 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-JDQ-4432653994-10-4(S)-NVP-JDQ443RasPERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseNCI-H358 cellNCI-H2122 cellBa/F3 cellsAntitumor activityOrally activeNSCLCEsophageal cancerPDACInhibitorinhibitorinhibit

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