2. Cell Cycle/DNA Damage
  3. CDK
  4. (S)-Roscovitine

(S)-Roscovitine  (Synonyms: (S)-Seliciclib; (S)-CYC202)

Cat. No.: HY-112403
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(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke.

For research use only. We do not sell to patients.

(S)-Roscovitine Chemical Structure

(S)-Roscovitine Chemical Structure

CAS No. : 186692-45-5

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Other Forms of (S)-Roscovitine:

(S)-Roscovitine Related Antibodies

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Description

(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].

IC50 & Target[1]

CDK1

≤1 μM (IC50)

CDK2

≤1 μM (IC50)

CDK5

≤1 μM (IC50)

CDK7

≤1 μM (IC50)

CDK9

≤1 μM (IC50)

In Vivo

(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) shows neuroprotective efficacy in an adult mouse model of permanent MCAo (middle cerebral artery occlusion) [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-25 g, P60 male C57 b/6 mice[2]
Dosage: 25 mg/kg
Administration: I.p.; at 15 min before and 1 hr after pMCAo
Result: Decreased of the total infarct volume.
Molecular Weight

354.45

Formula

C19H26N6O
CAS No.
SMILES

CC[C@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-Roscovitine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Roscovitine186692-45-5(S)-Seliciclib (S)-CYC202CDKCyclin dependent kinasePMCAoneuroprotectivecross the blood-brain barrierInhibitorinhibitorinhibit

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