(S)-STX-478

Cat. No.: HY-156681A Purity: 99.18% ee.: 100.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S)-STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of PI3Kα mutants, preventing metabolic dysfunction and demonstrating antitumor activity in xenograft mouse models with PI3Kα mutant tumors.

For research use only. We do not sell to patients.

(S)-STX-478 Chemical Structure

CAS No. : 2883540-91-6

Size	Price	Stock	Quantity
1 mg	USD 410	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 940	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1525	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3055	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4888	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 7820	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of (S)-STX-478:

STX-478 Get quote

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Purity & Documentation
References
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Description

Molecular Weight

401.29

Formula

C₁₆H₁₂F₅N₅O₂

CAS No.

2883540-91-6

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=C(C=N1)NC(N[C@@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (249.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4920 mL	12.4598 mL	24.9196 mL
5 mM	0.4984 mL	2.4920 mL	4.9839 mL
10 mM	0.2492 mL	1.2460 mL	2.4920 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.18% ee.: 100.00%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (248 KB) HNMR (143 KB) RP-HPLC (254 KB) NP-HPLC (317 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

References

[1]. Buckbinder L, et al. STX-478, a mutant-selective, allosteric PI3Kα inhibitor spares metabolic dysfunction and improves therapeutic response in PI3Kα-mutant xenografts[J]. Cancer Discovery, 2023, 13(11): 2432-2447. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4920 mL	12.4598 mL	24.9196 mL	62.2991 mL
	5 mM	0.4984 mL	2.4920 mL	4.9839 mL	12.4598 mL
	10 mM	0.2492 mL	1.2460 mL	2.4920 mL	6.2299 mL
	15 mM	0.1661 mL	0.8307 mL	1.6613 mL	4.1533 mL
	20 mM	0.1246 mL	0.6230 mL	1.2460 mL	3.1150 mL
	25 mM	0.0997 mL	0.4984 mL	0.9968 mL	2.4920 mL
	30 mM	0.0831 mL	0.4153 mL	0.8307 mL	2.0766 mL
	40 mM	0.0623 mL	0.3115 mL	0.6230 mL	1.5575 mL
	50 mM	0.0498 mL	0.2492 mL	0.4984 mL	1.2460 mL
	60 mM	0.0415 mL	0.2077 mL	0.4153 mL	1.0383 mL
	80 mM	0.0311 mL	0.1557 mL	0.3115 mL	0.7787 mL
	100 mM	0.0249 mL	0.1246 mL	0.2492 mL	0.6230 mL

(S)-STX-478 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-STX-4782883540-91-6OthersInhibitorinhibitorinhibit

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