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  4. (S)-STX-478

(S)-STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of PI3Kα mutants, preventing metabolic dysfunction and demonstrating antitumor activity in xenograft mouse models with PI3Kα mutant tumors.

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(S)-STX-478 Chemical Structure

(S)-STX-478 Chemical Structure

CAS No. : 2883540-91-6

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1 mg USD 410 In-stock
5 mg USD 940 In-stock
10 mg USD 1525 In-stock
25 mg USD 3055 In-stock
50 mg USD 4888 In-stock
100 mg USD 7820 In-stock
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(S)-STX-478 Related Antibodies

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Description

(S)-STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of PI3Kα mutants, preventing metabolic dysfunction and demonstrating antitumor activity in xenograft mouse models with PI3Kα mutant tumors[1].

Molecular Weight

401.29

Formula

C16H12F5N5O2
CAS No.
SMILES

NC1=NC=C(C=N1)NC(N[C@@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (249.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4920 mL 12.4598 mL 24.9196 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL
View the Complete Stock Solution Preparation Table

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In Vivo Dissolution Calculator
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4920 mL 12.4598 mL 24.9196 mL 62.2991 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL 12.4598 mL
10 mM 0.2492 mL 1.2460 mL 2.4920 mL 6.2299 mL
15 mM 0.1661 mL 0.8307 mL 1.6613 mL 4.1533 mL
20 mM 0.1246 mL 0.6230 mL 1.2460 mL 3.1150 mL
25 mM 0.0997 mL 0.4984 mL 0.9968 mL 2.4920 mL
30 mM 0.0831 mL 0.4153 mL 0.8307 mL 2.0766 mL
40 mM 0.0623 mL 0.3115 mL 0.6230 mL 1.5575 mL
50 mM 0.0498 mL 0.2492 mL 0.4984 mL 1.2460 mL
60 mM 0.0415 mL 0.2077 mL 0.4153 mL 1.0383 mL
80 mM 0.0311 mL 0.1557 mL 0.3115 mL 0.7787 mL
100 mM 0.0249 mL 0.1246 mL 0.2492 mL 0.6230 mL
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(S)-STX-478 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-STX-4782883540-91-6OthersInhibitorinhibitorinhibit

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