S1R agonist 1 hydrochloride

Name: S1R agonist 1 hydrochloride
Brand: MedChemExpress
SKU: HY-149803A
Rating: 4.5 (1 reviews)

Cat. No.: HY-149803A Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with K_is of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity.

For research use only. We do not sell to patients.

S1R agonist 1 hydrochloride Chemical Structure

CAS No. : 242487-82-7

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5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of S1R agonist 1 hydrochloride:

S1R agonist 1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Ki: 0.93 nM and 72 nM for S1R and S2R^[1]

In Vitro

S1R agonist 1 (Compound 6b; 0.1-5 μM) hydrochloride significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner in PC12 cell lines^[1].
S1R agonist 1 (24 h) hydrochloride significantly prevents cell damage induced by Rotenone (HY-B1756) when tested at the concentration of 1 μM in SHSY5Y cells^[1].
S1R agonist 1 (0.1-5 μM; 24 h) hydrochloride demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells^[1].
S1R agonist 1 (0-10 μM; 24-72 h) hydrochloride shows no cytotoxicity against A549, LoVo and Panc-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S1R agonist 1 (Compound 6b; 0.1-50 μM; 120 h) hydrochloride induces the death of 4 Zebrafish embryos out of 8 at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.88

Formula

C₂₀H₂₆ClNO

CAS No.

242487-82-7

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.C1(OCCN2CCC(CC2)CC3=CC=CC=C3)=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (301.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0131 mL	15.0657 mL	30.1314 mL
5 mM	0.6026 mL	3.0131 mL	6.0263 mL
10 mM	0.3013 mL	1.5066 mL	3.0131 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (244 KB) HNMR (272 KB) RP-HPLC (396 KB)

Handling Instructions (2659 KB)

References

[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0131 mL	15.0657 mL	30.1314 mL	75.3284 mL
	5 mM	0.6026 mL	3.0131 mL	6.0263 mL	15.0657 mL
	10 mM	0.3013 mL	1.5066 mL	3.0131 mL	7.5328 mL
	15 mM	0.2009 mL	1.0044 mL	2.0088 mL	5.0219 mL
	20 mM	0.1507 mL	0.7533 mL	1.5066 mL	3.7664 mL
	25 mM	0.1205 mL	0.6026 mL	1.2053 mL	3.0131 mL
	30 mM	0.1004 mL	0.5022 mL	1.0044 mL	2.5109 mL
	40 mM	0.0753 mL	0.3766 mL	0.7533 mL	1.8832 mL
	50 mM	0.0603 mL	0.3013 mL	0.6026 mL	1.5066 mL
	60 mM	0.0502 mL	0.2511 mL	0.5022 mL	1.2555 mL
	80 mM	0.0377 mL	0.1883 mL	0.3766 mL	0.9416 mL
	100 mM	0.0301 mL	0.1507 mL	0.3013 mL	0.7533 mL