1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV-2 3CLpro-IN-20

SARS-CoV-2 3CLpro-IN-20 (Compound 5g) is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM, Ki: ?0.33?μM).

For research use only. We do not sell to patients.

SARS-CoV-2 3CLpro-IN-20 Chemical Structure

SARS-CoV-2 3CLpro-IN-20 Chemical Structure

CAS No. : 878985-00-3

Size Price Stock Quantity
5 mg USD 48 In-stock
10 mg USD 77 In-stock
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Based on 1 publication(s) in Google Scholar

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  • Purity & Documentation

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Description

SARS-CoV-2 3CLpro-IN-20 (Compound 5g) is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM, Ki: ?0.33?μM)[1].

IC50 & Target

0.43 μM (SARS-CoV-2 3CLpro)[1]

Molecular Weight

366.21

Formula

C19H12BrNO2

CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C(C1=C(N2CC3=CC=C(C=CC=C4)C4=C3)C=CC(Br)=C1)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.76 mg/mL (13.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7307 mL 13.6534 mL 27.3067 mL
5 mM 0.5461 mL 2.7307 mL 5.4613 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7307 mL 13.6534 mL 27.3067 mL 68.2668 mL
5 mM 0.5461 mL 2.7307 mL 5.4613 mL 13.6534 mL
10 mM 0.2731 mL 1.3653 mL 2.7307 mL 6.8267 mL
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SARS-CoV-2 3CLpro-IN-20 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SARS-CoV-2 3CLpro-IN-20
Cat. No.:
HY-155187
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