SB-747651A dihydrochloride

Name: SB-747651A dihydrochloride
Brand: MedChemExpress
SKU: HY-110313
Rating: 4.5 (1 reviews)

Cat. No.: HY-110313 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC₅₀ of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research.

For research use only. We do not sell to patients.

SB-747651A dihydrochloride Chemical Structure

CAS No. : 1781882-72-1

Size	Price	Stock	Quantity
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SB-747651A dihydrochloride:

SB-747651A Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 11 nM (MSK1)^[1]

In Vitro

SB-747651A dihydrochloride (5 μM; neutrophils) affects CXCL2-induced intraluminal crawling of neutrophils in a Mac-1-dependent manner. SB-747651A dihydrochloride thwarts the intraluminal crawling of adherent neutrophils to optimal sites of emigration. SB-747651A dihydrochloride (5 μM; neutrophils) significantly increases transmigration time and detachment time. SB-747651A dihydrochloride affects mechanisms that regulate transendothelial migration of neutrophils in response to CXCL2 chemotactic gradient. SB-747651A dihydrochloride inhibits the migration speed of extravascular chemotaxing neutrophils but does not affect their directionality in response to CXCL2 chemotactic gradient^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB747651A (3 mg/kg; intrascrotal injection) dihydrochloride results in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2^[3].
SB-747651A (3 mg/kg; i.p.) dihydrochloride affects neutrophil extravasation by increasing neutrophil emigration only at 3 and 4 hours in mouse peritonitis model of acute inflammation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6N mice (8~16 weeks)^[3]
Dosage:	3 mg/kg
Administration:	Intrascrotal injection
Result:	Resulted in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2.

Molecular Weight

415.32

Formula

C₁₆H₂₄Cl₂N₈O

CAS No.

1781882-72-1

Appearance

Solid

Color

White to off-white

SMILES

NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (120.39 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4078 mL	12.0389 mL	24.0778 mL
5 mM	0.4816 mL	2.4078 mL	4.8156 mL
10 mM	0.2408 mL	1.2039 mL	2.4078 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (253 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Shaista Naqvi, et al. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012 Jan 1;441(1):347-57. [Content Brief]

[2]. Feiner B, et al. Risperidone effects on heterochromatin: the role of kinase signaling. Clin Exp Immunol. 2019;196(1):67-75. [Content Brief]

[3]. Hossain M, et al. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18(10):2163. Published 2017 Oct 17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.4078 mL	12.0389 mL	24.0778 mL	60.1945 mL
	5 mM	0.4816 mL	2.4078 mL	4.8156 mL	12.0389 mL
	10 mM	0.2408 mL	1.2039 mL	2.4078 mL	6.0195 mL
	15 mM	0.1605 mL	0.8026 mL	1.6052 mL	4.0130 mL
	20 mM	0.1204 mL	0.6019 mL	1.2039 mL	3.0097 mL
	25 mM	0.0963 mL	0.4816 mL	0.9631 mL	2.4078 mL
	30 mM	0.0803 mL	0.4013 mL	0.8026 mL	2.0065 mL
	40 mM	0.0602 mL	0.3010 mL	0.6019 mL	1.5049 mL
	50 mM	0.0482 mL	0.2408 mL	0.4816 mL	1.2039 mL
	60 mM	0.0401 mL	0.2006 mL	0.4013 mL	1.0032 mL
	80 mM	0.0301 mL	0.1505 mL	0.3010 mL	0.7524 mL
	100 mM	0.0241 mL	0.1204 mL	0.2408 mL	0.6019 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.