2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

PKC

Protein kinase C

PKC

Related Products

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-18739
    Phorbol 12-myristate 13-acetate
    		Activator 99.80%
    Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells.
    Phorbol 12-myristate 13-acetate
  • HY-15371
    Forskolin
    		Inhibitor 99.78%
    Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
    Forskolin
  • HY-15141
    Staurosporine
    		Inhibitor 99.98%
    Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.
    Staurosporine
  • HY-13434
    Ionomycin
    		Activator ≥99.0%
    Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).
    Ionomycin
  • HY-13689
    Go 6983
    		Inhibitor 99.32%
    Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
    Go 6983
  • HY-401475
    Protein kinase inhibitor 9
    		Inhibitor
    Protein kinase inhibitor 9 (Compound example 175) is an inhibitor of serine/threonine and tyrosine kinase activity. Protein kinase inhibitor 9 can be used for the research of cancer, hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.
    Protein kinase inhibitor 9
  • HY-164756
    PKCTheta-IN-2
    		Inhibitor 99.49%
    PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC50 of 682 nM).
    PKCTheta-IN-2
  • HY-P10256A
    Kiss2 peptide acetate
    		Activator
    Kiss2 peptide acetate is the acetate form of Kiss2 pepride (HY-P10256). Kiss2 peptide acetate is a positive regulator of reproduction. Kiss2 peptide acetate binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).
    Kiss2 peptide acetate
  • HY-13502
    Mitoxantrone
    		Inhibitor 99.58%
    Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.
    Mitoxantrone
  • HY-10230
    Midostaurin
    		Inhibitor 99.91%
    Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, VEGFR2/KDR/Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/Flt-1/2 with IC50s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects.
    Midostaurin
  • HY-10341
    Fasudil Hydrochloride
    		Inhibitor 99.97%
    Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil Hydrochloride
  • HY-13434A
    Ionomycin calcium
    		Activator ≥98.0%
    Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC).
    Ionomycin calcium
  • HY-13867
    Bisindolylmaleimide I
    		Inhibitor 98.66%
    Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor.
    Bisindolylmaleimide I
  • HY-18980
    Rottlerin
    		Inhibitor 98.39%
    Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection.
    Rottlerin
  • HY-N0021
    Verbascoside
    		Inhibitor 99.83%
    Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.
    Verbascoside
  • HY-10343
    Sotrastaurin
    		Inhibitor 99.79%
    Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.
    Sotrastaurin
  • HY-13502A
    Mitoxantrone dihydrochloride
    		Inhibitor 99.55%
    Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.
    Mitoxantrone dihydrochloride
  • HY-18985
    Phorbol 12,13-dibutyrate
    		Activator 99.77%
    Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.
    Phorbol 12,13-dibutyrate
  • HY-101047
    D-erythro-Sphingosine
    		Inhibitor ≥98.0%
    D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
    D-erythro-Sphingosine
  • HY-N0453
    Hypericin
    		Inhibitor 98.03%
    Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis.
    Hypericin
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKC-ι ℩

PKCι

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PKC Inhibitors, Antagonists, Activators & Modulators
Product NamePKCPKCαPKCβPKCγPKCδPKCεPKCηPKCζPKCθPKCμPKC-ι ℩PKCιPurity    
Phorbol 12-myristate 13-acetate
PKC, EC50: 11.7 nM
           99.80%
Staurosporine
PKC, IC50: 6 nM
           99.98%
Go 6983 
PKCα, IC50: 7 nM
PKCβ, IC50: 7 nM
PKCγ, IC50: 6 nM
PKCδ, IC50: 10 nM
  
PKCζ, IC50: 60 nM
 
PKCμ, IC50: 20000 nM
  99.32%
PKCTheta-IN-2        
PKCθ, IC50: 0.25 nM
   99.49%
Mitoxantrone
PKC, IC50: 8.5 μM
           99.58%
Midostaurin 
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
    99.91%
Fasudil Hydrochloride
PKC, IC50: 12.30 μM
           99.97%
Bisindolylmaleimide I
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
        98.66%
Rottlerin 
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
    98.39%
Verbascoside
PKC, IC50: 25 μM
           99.83%
Sotrastaurin 
PKCα, Ki: 0.95 nM
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
   99.79%
Mitoxantrone dihydrochloride
PKC, IC50: 8.5 μM
           99.55%
D-erythro-Sphingosine
PKC
           ≥98.0%
Chelerythrine chloride
PKC, IC50: 660 nM
           99.42%
Enzastaurin 
PKCα, IC50: 39 nM
PKCβ, IC50: 6 nM
PKCγ, IC50: 83 nM
 
PKCε, IC50: 110 nM
      99.92%
Ingenol Mebutate 
PKC-α, Ki: 0.3 nM
PKC-β, Ki: 0.105 nM
PKC-γ, Ki: 0.162 nM
PKC-δ, Ki: 0.376 nM
PKC-ε, Ki: 0.171 nM
      99.65%
Afuresertib  
PKC-βI, IC50: 430 nM
   
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
   99.53%
TPPB
PKC, Ki: 11.9 nM
           99.92%
Darovasertib 
PKCα, IC50: 1.9 nM
      
PKCθ, IC50: 0.4 nM
   99.42%
DCP-LA     
PKCε
      ≥98.0%
Ro 31-8220 mesylate
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
      99.57%
Daphnetin
PKC, IC50: 25.01 μM
           99.86%
CGP60474
PKC
           99.23%
KT5823
PKC, Ki: 4 μM
           99.90%
BJE6-106 
PKCα, IC50: 50 μM
  
PKCδ, IC50: 0.05 μM
       99.93%
Ruboxistaurin 
PKCα, IC50: 360 nM
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
     99.48%
Prostratin
PKC, Ki: 12.5 nM
           99.80%
CMPD101 
PKCα, IC50: 8.1 μM
          98.95%
R 59-022
PKC
           99.82%
Ingenol
PKC, Ki: 30 μM
           99.51%
(-)-Indolactam V 
PKCα-C1A-long, Kd: 20.8 nM
PKCα-C1B-long, Kd: 4000 nM
PKCβ-C1A-long, Kd: 18.9 nM
PKCβ-C1B, Kd: 137 nM
PKCγ-C1A, Kd: 138 nM
PKCγ-C1B, Kd: 213 nM
PKCγ-CRD2, Ki: 1030 nM
PKCδ-C1B, Kd: 8.3 nM
PKCδ-C1A, Kd: 1900 nM
PKCε-C1B, Kd: 7.7 nM
PKCε-C1A, Kd: 4110 nM
PKCη-CRD2, Ki: 3.36 nM
PKCη-C1B, Kd: 5.5 nM
PKCη-C1A, Kd: 3770 nM
 
PKCθ-C1B, Kd: 8.7 nM
   98.75%
Valrubicin
TPA-activated PKC, IC50: 0.85 μM
PDBu-activated PKC, IC50: 1.25 μM
           99.60%
CC-90005        
PKCθ, IC50: 8 nM
   99.67%
Epsilon-V1-2     
PKCε
      
VTX-27 
PKCα, Ki: 356 nM
  
PKCδ, Ki: 16 nM
   
PKCθ, Ki: 0.08 nM
   99.02%
PKCβ inhibitor 1 
PKCα, IC50: 331 nM
human PKCβ1, IC50: 21 nM
human PKCβ2, IC50: 5 nM
         99.40%
PKC-IN-1 
Human PKCα, IC50: 2.3 nM
Human PKCα, Ki: 10.4 nM
Human PKCβII, IC50: 7.6 nM
Human PKCβI, IC50: 8.1 nM
Human PKCβ, Ki: 5.3 nM
Human PKCγ, IC50: 57.5 nM
 
Human PKCε, IC50: 808 nM
  
Human PKCθ, IC50: 25.6 nM
Human PKC mu, IC50: 314 nM
  99.79%
PKC-theta inhibitor 2        
PKCθ, IC50: 18 nM
   99.37%
Delcasertib hydrochloride    
δPKC
       99.86%
HA-100
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
           99.80%
CRT0066854       
PKCζ, IC50: 639 nM
    99.54%
Aurothiomalate sodium           
PKCι
≥98.0%
Bisindolylmaleimide X hydrochloride
PKC
           98.90%
Ruboxistaurin hydrochloride 
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
     99.94%
SB-218078
PKC, IC50: 1000 nM
           98.30%
Afuresertib hydrochloride  
PKC-βI, IC50: 430 nM
   
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
   99.95%
TCS 21311 
PKCα, IC50: 13 nM
      
PKCθ, IC50: 68 nM
   99.18%
Psychosine
PKC
           ≥99.0%
N-Desmethyltamoxifen hydrochloride
PKC
           99.93%
ζ-Stat       
aPKC-ζ, IC50: 5 μM
    
PKCiota-IN-2 formic 
PKCα, IC50: 71 nM
   
PKCε, IC50: 350 nM
     
PKCι, IC50: 2.8 nM
99.04%
PKC-theta inhibitor 1 
PKCα, Ki: 1020 μM
  
PKCδ, Ki: 392 μM
   
PKCθ, Ki: 6 nM
   99.73%
PS432       
PKCζ, IC50: 18.5 μM
   
PKCι, IC50: 16.9 μM
≥99.0%
Bisindolylmaleimide IV
PKC, IC50: 0.1-0.55 μM
           99.62%
Bisindolylmaleimide VIII acetate
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
 
PKC-ε, IC50: 175 nM
      99.68%
Bisindolylmaleimide I hydrochloride
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKC-βII, IC50: 16 nM
PKC-βI, IC50: 17 nM
PKCγ, IC50: 20 nM
        99.18%
C8-Ceramide
PKC
           ≥98.0%
R 59-022 hydrochloride
PKC
           98.88%
Spisulosine       
PKCζ
    99.00%
Protein kinase inhibitor H-7
PKC, Ki: 6 μM
           99.96%
Bisindolylmaleimide III 
PKCα
          98.95%
ML192  
PKCβII
         
Ruboxistaurin mesylate 
PKCα, IC50: 360 nM
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
     99.87%
Sphingosine (d14:1)
PKC
           ≥99.0%
CRT0066854 hydrochloride       
PKCζ, IC50: 639 nM
    99.29%
Bisindolylmaleimide XI hydrochloride 
PKC-α, IC50: 9 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 31 nM
PKC-γ, IC50: 37 nM
 
PKC-ε, IC50: 108 nM
      ≥98.0%
A-3 hydrochloride
PKC, Ki: 47 μM
           99.75%
DCPLA-ME     
PKCε
      ≥98.0%
SB 220025
PKC, IC50: 2.89 μM
           99.90%
PF-4950834      
PKCη, IC50: 756 nM
     99.60%
Hu7691      
PKCη, IC50: 629 nM
     
ζ-Stat trisodium       
aPKC-ζ, IC50: 5 μM
    
Chelerythrine
PKC, IC50: 0.7 μM
           
CGP-53353  
PKCβII, IC50: 0.41 mM
PKCβI, IC50: 3.8 mM
         98.87%
OSU-2S    
PKCδ
       
TAS-301
PKC
           99.61%
Delcasertib    
δPKC
       98.21%
(S)-Ro 32-0432 
PKCα, IC50: 9.3 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
PKCγ, IC50: 36.5 nM
 
PKCε, IC50: 108.3 nM
      
Fasudil
PKC, IC50: 12.3 μM
           
Hu7691 free base      
PKCη, IC50: 629 nM
     
Fasudil dihydrochloride
PKC, IC50: 12.3 μM
           
Mitoxantrone diacetate
PKC, IC50: 8.5 μM
           
Fasudil hydrochloride semihydrate
PKC, IC50: 12.3 μM
           
PKC-IN-4
PKC, IC50: 0.52 μM
           
PKCiota-IN-2 
PKCα, IC50: 71 nM
   
PKCε, IC50: 350 nM
     
PKCι, IC50: 2.8 nM
N-Desmethyltamoxifen
PKC
           
HBDDE 
PKCα, IC50: 43 μM
 
PKCγ, IC50: 50 μM
        98.03%
PKC β pseudosubstrate  
PKC-β
         98.98%
Evo312  
PKC-βI, IC50: 117.34 nM
         
CDK8-IN-12        
PKCθ, Ki: 109 nM
   99.74%
PS315      
PKCη, IC50: 30 μM
PKCζ, IC50: 10 μM
    
PKCTheta-IN-1        
PKCθ, IC50: 0.1 nM
   
[Ala113]MBP(104-118)
PKC, IC50: 28-62 μM
           
PF-04577806 
PKCα, IC50: 2.4 nM
PKCβI, IC50: 8.1 nM
PKCβII, IC50: 6.9 nM
PKCγ, IC50: 45.9 nM
PKCδ, IC50: 586 nM
PKCε, IC50: 522 nM
  
PKCθ, IC50: 29.5 nM
   
Leucosceptoside A 
PKCα, IC50: 19 μM
          
PKCδ Peptide Substrate    
PKCδ
       
AS2521780 
PKCα, IC50: 160 nM
  
PKCδ, IC50: 160 nM
PKCε, IC50: 18 nM
  
PKCθ, IC50: 0.48 nM
   
Aurora A/PKC-IN-1 
PKCα, IC50: 16.9 nM
          
HA-100 hydrochloride
PKC, IC50: 12 μM
           
PF-03622905 
PKCα, IC50: 5.6 nM
PKCβI, IC50: 14.5 nM
PKCβII, IC50: 13 nM
PKCγ, IC50: 37.7 nM
    
PKCθ, IC50: 74.1 nM
   
[Ala107]MBP(104-118)
PKC, IC50: 46-145 μM
           
HA-100 dihydrochloride
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
           
PKC β pseudosubstrate TFA  
PKCβ
         
[Ala113]MBP(104-118) TFA
PKC, IC50: 28-62 μM
           
PKCiota-IN-1 
PKCα, IC50: 45 nM
   
PKCε, IC50: 450 nM
     
PKCι, IC50: 2.7 nM
CIDD-0072424     
PKCε, Ki: 54 nM
      
GSK-3β inhibitor 13        
PKCθ, IC50: 0.36 μM
   
[Ala107]MBP(104-118) TFA
PKC, IC50: 46-145 μM
           
Dioleyl phosphatidylserine   
PKCγ
        
(Rac)-Aurora A/PKC-IN-1 
PKCα, IC50: 16.9 nM
PKCβI, IC50: 12.1 nM
PKCβII, IC50: 11.3 nM
     
PKCθ, IC50: 4.2 nM
   
Bisindolylmaleimide VIII
Rat Brain PKC, IC50: 158 nM
PKCα, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKCγ, IC50: 213 nM
 
PKCε, IC50: 175 nM
      
Balanol 
Human PKCα, : 4-9 nM
PKC-βI, : 4-9 nM
PKC-βII, : 4-9 nM
Human PKCγ, : 4-9 nM
Human PKCδ, : 4-9 nM
Human PKCε, : 4-9 nM
human PKCη, : 150 nM
     
CMPD101 hydrochloride 
PKCα, IC50: 8.1 μM