ROR

RAR-related orphan receptor

ROR

ROR Isoform Specific Products:

ROR Isoform Comparison

ROR Related Products (110)
Antibodies (5)
ROR Isoform Comparison

By Effects:	Inhibitors (43) Agonists (22) Degraders (2) Antagonists (32) Activator (1) Modulators (7)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10626

T0901317	Antagonist	99.93%
T0901317 is an orally active and highly selective LXR agonist with an EC₅₀ of 20 nM for LXRα. T0901317 activates FXR with an EC₅₀ of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

HY-N0155

Nobiletin	Agonist	99.79%
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.

HY-14422

SR1078	Agonist	99.75%
SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ). SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription.

HY-125801

3-Oxo-5β-cholanoic acid	Inhibitor	99.37%
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (K_d=1.13 μM).

HY-14413

SR3335	Antagonist	98.49%
SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a K_i of 220 nM.

HY-125801R

3-Oxo-5β-cholanoic acid (Standard)	Inhibitor
3-Oxo-5β-cholanoic acid (Standard) is the analytical standard of 3-Oxo-5β-cholanoic acid. This product is intended for research and analytical applications. 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].

HY-P99201

Zilovertamab	Inhibitor	98.21%
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.

HY-12776

GSK805	Inhibitor	98.01%
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC₅₀ values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.

HY-13421

SR1001	Inhibitor	99.89%
SR1001 is a selective ROR_α and ROR_γt inverse agonist with K_is 172 and 111 nM, respectively.

HY-104037

Cintirorgon	Agonist	99.14%
Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.

HY-120210

XY018	Antagonist	99.68%
XY018 is a potent ROR-γ-selective antagonist. XY018 inhibits ROR-γ constitutive activity in 293T cells with high potency (EC₅₀, 190 nM). XY018 binds to the ROR-γ hydrophobic ligand binding domain (LBD).

HY-139534

ARI-1	Inhibitor	99.76%
ARI-1 is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 effectively inhibits aberrant ROR1 expression, which is associated with the development of non-small cell lung cancer (NSCLC) and EGFR-TKI-induced drug resistance. ARI-1 binds to the extracellular Frizzled domain of ROR1 and regulates PI3K/AKT/mTOR signaling in a ROR1-dependent manner. ARI-1 potently inhibits NSCLC cell proliferation and migration and has antitumor activity in vivo^{[1]^.}

HY-16998

SR2211	Antagonist	99.67%
SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a K_i of 105 nM and an IC₅₀ of ~320 nM.

HY-101454

SR0987	Agonist	99.65%
SR0987, a SR1078 analog, is a RORγt agonist, with an EC₅₀ of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1.

HY-N2253

Neoruscogenin	Agonist	99.24%
Neoruscogenin, a member of the steroidal sapogenin family, is a high-affinity agonist of the nuclear receptor RORα (NR1F1) (EC₅₀ = 0.11 µM).

HY-19775

GNE-6468	Antagonist	98.04%
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC₅₀ value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC₅₀ of 30 nM for IL-17 PBMC.

HY-19770

GSK2981278	Antagonist	99.51%
GSK2981278 is a potent and selective RORγ inverse agonist. GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding.

HY-113345

Zymostenol	Agonist	99.33%
Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC₅₀: 1 μM).

HY-102075A

TMP778	Antagonist	99.99%
TMP778 is a potent and selevtive RORγt inverse agonist, with an IC₅₀ of 7 nM in FRET assay.

HY-139780

JNJ-61803534	Inhibitor	99.88%
JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC₅₀ of 9.6 nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions.

XY018	ROR-γ, IC₅₀: 0.19 μM (in 293 T cells)	ROR-α, IC₅₀: 7.57 μM (in 293 T cells)		99.68%
GNE-6468	ROR-γ, EC₅₀: 2 nM			98.04%
Zymostenol	RORγ, EC₅₀: 1 μM			99.33%
JNJ-61803534	RORγt			99.88%
F44-A13	RORγ
RORγt inverse agonist 13	ROR-γ, IC₅₀: 63.8 nM			98.13%
SR1555	RORγ, IC₅₀: 1 μM			99.69%
Vimirogant hydrochloride	RORγt, Ki: 3.5 nM RORγt, IC₅₀: 17 nM			98.39%
7ß,27-Dihydroxycholesterol	RORγt, Ki: 120 nM			≥99.0%
RORγt Inverse agonist 10	RORγt, IC₅₀: 51 nM			99.13%
S18-000003	RORγt, IC₅₀: <30 nM			99.31%
(±)-ML 209	RORγ, IC₅₀: 1.1 μM			99.87%
GNE-3500	ROR-γ, EC₅₀: 12 nM			98.90%
BMS-986251	RORγt, EC₅₀: 12 nM	RORα, EC₅₀: >10 μM	RORβ, EC₅₀: >10 μM
A-9758	RORγt, IC₅₀: 5 nM
SHR168442	ROR-γ
W6134	RORγ, IC₅₀: 0.21 μM			99.90%
RORγt modulator 5	RORγt, Ki: <100 nM
RORγt modulator 4	RORγt
RORγt inhibitor 4	RORγt
RORγt inverse agonist 33	RORγt, IC₅₀: 21 nM
XY039	RORγ, IC₅₀: 0.55 μM
RORγt inverse agonist 34	RORγt, IC₅₀: 0.094 μM
RORγt inverse agonist 32	RORγt
RORγt inverse agonist 29	RORγt, IC₅₀: 21 nM
CD12681	RORγ
RORγ-IN-2	RORγ, Ki: 16.6 nM
RORγt inverse agonist 30	RORγt, IC₅₀: 46 nM
CID 7309015	ROR-γ
SR-1903	RORγ, IC₅₀: ~100 nM
Vimirogant	RORγt, Ki: 3.5 nM RORγt, IC₅₀: 17 nM

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ROR

ROR

ROR Isoform Specific Products:

ROR Isoform Specific Products:

ROR Related Products (110)

Antibodies (5)

ROR Isoform Comparison

ROR Related Products (110):