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Results for "

senescent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (9) Autophagy (2) Bacterial (1) Bcl-2 Family (4) Drug Derivative (1) Endogenous Metabolite (1) Endonuclease (1) Epigenetic Reader Domain (1) ERK (1) Fluorescent Dye (1) Glycosidase (1) Histone Acetyltransferase (1) Histone Methyltransferase (2) Imidazoline Receptor (1) MDM-2/p53 (2) Mitochondrial Metabolism (2) p38 MAPK (1) p62 (2) Parasite (2) PROTACs (1) Reactive Oxygen Species (3)
By Research Areas:	Cancer (10) Infection (4) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (1)

By Targets:

Antibiotic (1)

Apoptosis (9)

Autophagy (2)

Bacterial (1)

Bcl-2 Family (4)

Drug Derivative (1)

Endogenous Metabolite (1)

Endonuclease (1)

Epigenetic Reader Domain (1)

ERK (1)

Fluorescent Dye (1)

Glycosidase (1)

Histone Acetyltransferase (1)

Histone Methyltransferase (2)

Imidazoline Receptor (1)

MDM-2/p53 (2)

Mitochondrial Metabolism (2)

p38 MAPK (1)

p62 (2)

Parasite (2)

PROTACs (1)

Reactive Oxygen Species (3)

By Research Areas:

Cancer (10)

Infection (4)

Inflammation/Immunology (7)

Metabolic Disease (8)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138832

BM-1244 APG-1252-M1	Bcl-2 Family	Cancer
BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor with K_is of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC₅₀ of 5 nM. (From patent WO2019033119A1) .

HY-P4157

FOXO4-DRI	MDM-2/p53 Apoptosis	Metabolic Disease
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells .

HY-65008

N-Demethylricinine	Others	Others
N-Demethylricinine is a ricinine, can be interconverted with ricinine in senescent and green castor plant leaves. Ricinine, is a α-pyridone alkaloid biosynthetically related to the pyridine nucleotide cycle. The alkaloid catabolism of ricinine is associated with aging process .

HY-158331

Gal-ARV-771	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells .

HY-169265

BRD-K20733377	Bcl-2 Family	Others
BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629)-induced IMR-90 senescent cell with an IC₅₀ of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model .

HY-131993

Resolvin E4 RvE4	Endogenous Metabolite	Inflammation/Immunology
Resolvin E4 (RvE4) is an endogenous metabolite that stimulates efferocytosis of apoptotic neutrophils and senescent erythrocytes. Resolvin E4 enhances resolution of hemorrhagic exudates and inflammation in vivo .

HY-157329

AD16	Endonuclease	Inflammation/Immunology
AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC₅₀ of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells .

HY-158742

SBB-Analogue (GL13) Biotin GL13; SBB-A-B	Fluorescent Dye	Others
SBB-Analogue (GL13) Biotin (GL13; SBB-A-B) is composed of a Sudan Black B (SBB; HY-D0213) derivative conjugated to biotin. SBB-Analogue (GL13) Biotin detects robustly senescent cells. SBB-Analogue (GL13) Biotin is deprived of the false positive staining disadvantages of SA-β-gal due to serum starvation and cell confluency. SBB-Analogue (GL13) Biotin can be used in flow cytometry and immunofluorescence analysis, etc .

HY-170851

GL392	Apoptosis	Cancer
GL392 is a senolytic agent that selectively delivers the potent senolytic compound Dasatinib (HY-10181) to senescent cells. GL392 targets lipofuscin in senescent cells via the LBD domain and is linked to Dasatinib through an ester bond. Upon internalization in senescent cells, Dasatinib is released, inducing apoptosis of the senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL micelles to ensure effective intracellular delivery and minimize systemic toxicity. GL392 can be used in cancer research applications .

HY-P4157A

FOXO4-DRI acetate	MDM-2/p53 Apoptosis	Metabolic Disease
FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI acetate is a senolytic peptide that induces apoptosis of senescent cells .

HY-169266

BRD-K56819078	Bcl-2 Family Apoptosis	Metabolic Disease
BRD-K56819078 is a Bcl-2 inhibitor that significantly reduces senescent cell load and senescence-related genes in the kidney mRNA expression. BRD-K56819078 exerts anti-aging effects by inhibiting apoptosis .

HY-138936

SSK1 1 Publications Verification	p38 MAPK Apoptosis	Inflammation/Immunology
SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis .

HY-161088

Anti-aging agent 1	Drug Derivative ERK	Others
Anti-aging agent 1 (compound 24) is a derivative of piperlongumine (HY-N2329) (PL). Anti-aging agent 1 exhibits a 50-fold enhancement in senolytic activity against senescent WI-38 fibroblasts compared to PL .

HY-150069

UBX1325	Bcl-2 Family Apoptosis	Metabolic Disease
UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR) .

HY-N15138

Sativanone	Glycosidase	Infection Metabolic Disease Inflammation/Immunology
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent α-glucosidase inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

HY-126222

MitoTam bromide, hydrobromide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam bromide, hydrobromide, a Tamoxifen derivative , is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells .

HY-N1458

Isoschaftoside 1 Publications Verification	Parasite Autophagy p62 Reactive Oxygen Species	Infection Metabolic Disease Inflammation/Immunology Cancer
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study .

HY-126222A

MitoTam iodide, hydriodide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .

HY-15647

BRD9539 1 Publications Verification	Histone Methyltransferase	Cancer
BRD9539 is a histone methyltransferase G9a inhibitor with an IC₅₀ of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1 .

HY-131035

Lys-CoA TFA	Histone Acetyltransferase	Cancer
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC₅₀=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC₅₀=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation .

HY-N1458R

Isoschaftoside (Standard)	Parasite Autophagy p62 Reactive Oxygen Species	Infection Metabolic Disease Inflammation/Immunology Cancer
Isoschaftoside (Standard) is the analytical standard of Isoschaftoside. This product is intended for research and analytical applications. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.

HY-17442

Azathramycin Azaerythromycin A; Desmethyl Azithromycin	Bacterial Antibiotic	Infection
Azathramycin (Desmethyl Azithromycin) is a macrolide antibiotic. Azathramycin is a derivative of the anti-ribosomal antibiotic Azithromycin (HY-17506). Azathramycin exerts its antibacterial activity by binding to ribosomes and inhibiting bacterial protein synthesis. Azathramycin can selectively target and kill human senescent fibroblasts and is expected to be used in anti-aging research. Azathramycin affects multiple ion channels such as SCN5A, hERG, KCNQ1 + KCNE1, L-type Ca ⁺⁺ and K_ir2.1 .

HY-P0104

Palmitoyl tripeptide-38	Reactive Oxygen Species	Metabolic Disease
Palmitoyl tripeptide-38 is a bioactive peptide with anti-aging effect .

HY-16705

BRD4770 3 Publications Verification	Histone Methyltransferase	Cancer
BRD4770 is a histone methyltransferase G9a inhibitor. BRD4770 reduces di- and trimethylation of lysine 9 on histone H3 (H3K9) with an EC₅₀ of 5 μM, and has less or little effect toward H3K27me3, H3K36me3, H3K4me3, and H3K79me3. BRD4770 can activate the ataxia telangiectasia mutated (ATM) pathway and induce cell senescence .

HY-170994

I2-IRs ligand-1	Imidazoline Receptor	Neurological Disease Inflammation/Immunology
I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penatrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I₂ receptors (I₂-IRs) (pK_i: 9.98). I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders .

FOXO4-DRI	MDM-2/p53 Apoptosis	Metabolic Disease
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells .

FOXO4-DRI acetate	MDM-2/p53 Apoptosis	Metabolic Disease
FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI acetate is a senolytic peptide that induces apoptosis of senescent cells .

Palmitoyl tripeptide-38	Reactive Oxygen Species	Metabolic Disease
Palmitoyl tripeptide-38 is a bioactive peptide with anti-aging effect .

N-Demethylricinine	Alkaloids Structural Classification Ricinus communis L. Euphorbiaceae Plants	Others
N-Demethylricinine is a ricinine, can be interconverted with ricinine in senescent and green castor plant leaves. Ricinine, is a α-pyridone alkaloid biosynthetically related to the pyridine nucleotide cycle. The alkaloid catabolism of ricinine is associated with aging process .

Isoschaftoside 1 Publications Verification	Structural Classification Classification of Application Fields Flavones Source classification Plants Desmodium uncinatum DC. Infection Flavonoids other families Leguminosae Phenols Polyphenols Disease Research Fields Cancer	Parasite Autophagy p62 Reactive Oxygen Species
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study .

Sativanone	Structural Classification Flavonoids Dalbergia tonkinensis Prain Leguminosae Isoflavanones Source classification Plants	Glycosidase
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent α-glucosidase inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

Isoschaftoside (Standard)	Structural Classification Flavonoids other families Flavones Leguminosae Source classification Phenols Polyphenols Plants Desmodium uncinatum DC.	Parasite Autophagy p62 Reactive Oxygen Species
Isoschaftoside (Standard) is the analytical standard of Isoschaftoside. This product is intended for research and analytical applications. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.

Cat. No.	Compare	Product Name	Species	Source

HY-P72064

	LIMS1 Protein, Mouse (Baculovirus, His) Lims1; Pinch1LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1	Mouse	Sf9 insect cells
	LIMS1 is an adapter protein that critically connects β-integrin to the actin cytoskeleton and cell surface receptors. It mediates important cellular processes and competes with LIMS2 by linking to integrin-linked protein kinase 1 (ILK) through its first LIM domain. LIMS1 Protein, Mouse (Baculovirus, His) is the recombinant mouse-derived LIMS1 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of LIMS1 Protein, Mouse (Baculovirus, His) is 324 a.a., with molecular weight of ~39.6 kDa.

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