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Isoforms Recommended:	15-LOX

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15-LOX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipoxygenase (24) Apoptosis (1) COX (12) Endogenous Metabolite (1) Ferroptosis (1) Interleukin Related (1) Mitochondrial Metabolism (1) NF-κB (1) PPAR (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (23) Metabolic Disease (3) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

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Targets Recommended: 15-PGDH LOX-1 Lipoxygenase Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138989

15-LOX-1 inhibitor 1	Lipoxygenase	Inflammation/Immunology
15-LOX-1 inhibitor 1 is a potent inhibitor of *15-LOX-1* (15-lipoxygenase-1) with an IC₅₀ value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation .

HY-161315

15-LOX-IN-1	Lipoxygenase	Inflammation/Immunology
15-LOX-IN-1 (Compound 7c) is a *15-LOX* inhibitor with a IC₅₀ value of 1.92 μM. 15-LOX-IN-1 has anti-inflammatory activity .

HY-173115

15-LOX-IN-2	COX Lipoxygenase Interleukin Related PPAR	Metabolic Disease Inflammation/Immunology
15-LOX-IN-2 (Compound 2a) is an orally active *COX-2/15-LOX* inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .

HY-150548

*COX-2/15-LOX-IN-1*	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC₅₀ values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity .

HY-155159

*COX-2/15-LOX-IN-2*	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX-IN-2 is a potent dual COX-2 and *15-LOX* inhibitor with IC₅₀ values of 0.065?μM and 1.86?μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity .

HY-168340

*COX-2/15-LOX-IN-6*	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX-IN-6 (Compound 5l) is the dual inhibitor for COX-2 and *15-LOX, with IC₅₀* of 0.201 μM and 11.723 μM. COX-2/15-LOX-IN-6 inhibits the expression of PGE, TNF-α, IL-6 and iNOS in serum, and exhibits anti-inflammatory effect in Carrageenan (HY-125474)-induced rats edema model .

HY-162166

*COX-2/15-LOX/mPGES1-IN-1*	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, *15-LOX, and mPGES-1* enzymes with IC₅₀ values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .

HY-161908

h15-LOX-2 inhibitor 3	Lipoxygenase	Inflammation/Immunology
h15-LOX-2 inhibitor 3 (Compound 13) is an inhibitor of *h15-LOX, with IC₅₀* and K_i values of 25 μM and 15.1 μM, respectively .

HY-161907

h15-LOX-2 inhibitor 2	Lipoxygenase	Inflammation/Immunology
h15-LOX-2 inhibitor 2 (Compound 10) is an inhibitor of *h15-LOX, with IC₅₀* and K_i values of 26.9 μM and 16.4 μM, respectively .

HY-168768

FerroLOXIN-1	Ferroptosis Lipoxygenase	Cancer
FerroLOXIN-1 is a potent inhibitor of *15LOX-2* that selectively blocked production of pro-ferroptotic HOO-ETE-PE and protected against RSL3-induced ferroptosis. FerroLOXIN-1 closely interacted therein with 15LOX-2 only, and in particular with Y154, N155, W158 .

HY-153930

h15-LOX-2 inhibitor 1	Lipoxygenase	Inflammation/Immunology
h15-LOX-2 inhibitor 1 (Comp 105) is a human epithelial 15-lipoxygenase-2 (h15-LOX-2) inhibitor with IC₅₀ of 0.34 μM .

HY-163355

*COX-2/15-LOX-IN-5*	COX Lipoxygenase NF-κB	Inflammation/Immunology
COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .

HY-155161

*COX-2/15-LOX-IN-4*	Lipoxygenase COX	Inflammation/Immunology
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor of COX-2/15-LOX with IC₅₀s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-4 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS) with specific anti-inflammatory activity .

HY-155160

*COX-2/15-LOX-IN-3*	Lipoxygenase COX	Inflammation/Immunology
COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC₅₀s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity .

HY-N2266

Benzoylgomisin O	COX	Inflammation/Immunology
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against *15-LOX, COX-1* and COX-2 enzymes and anti-inflammatory activity .

HY-150553

COX-2-IN-28	COX	Inflammation/Immunology
COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC₅₀ values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively .

HY-150551

COX-2-IN-27	COX	Inflammation/Immunology
COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity .

HY-113884B

(S)-Coriolic acid 13(S)-HODE	PPAR Mitochondrial Metabolism	Inflammation/Immunology Cancer
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury .

HY-117048

PF-4191834 PF-04191834	Lipoxygenase	Inflammation/Immunology
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC₅₀=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain .

HY-150550

COX-2-IN-26	COX	Inflammation/Immunology
COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC₅₀ values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile .

HY-145473

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE 15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine	Endogenous Metabolite	Metabolic Disease
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE (15(S)-HETE-SAPE) is a phospholipid containing stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE (HY-113336) at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is formed by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LOX in human peripheral mononuclear cells activated with the calcium ionophore A23187 (HY-N6687).

HY-114796

tHGA	Lipoxygenase	Inflammation/Immunology
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC₅₀ value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC₅₀ value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC₅₀ value of 0.40 μM .

HY-121585

CAY10698	Lipoxygenase	Inflammation/Immunology
CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC₅₀ of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2 .

HY-116124

17(S)-HpDHA	Lipoxygenase	Others
17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC₅₀ of approximately 1 μM .

HY-139196

ThioLox	Lipoxygenase	Neurological Disease Inflammation/Immunology
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a K_i of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties .

HY-118110

MLS000545091	Lipoxygenase	Inflammation/Immunology
MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC₅₀ value of 2.6 μM for h15-LOX-2 .

HY-111310

ML351 1 Publications Verification	Lipoxygenase	Neurological Disease Metabolic Disease
ML351 is a potent and highly specific *15-LOX-1* inhibitor with an IC₅₀ of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .

HY-127170

3-Hydroxycoumarin	Lipoxygenase	Others
3-hydroxycoumarin is a potent and redox inhibitor of human *15-LOX-1*. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage .

HY-118480

4-MMPB	Lipoxygenase Apoptosis	Cancer
4-MMPB is a selective inhibitor of *15-lipoxygenase, with an IC₅₀* of 18 μM. 4-MMPB has IC₅₀s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer .

HY-116919

MLS000536924	Lipoxygenase	Cardiovascular Disease
MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity .

(S)-Coriolic acid 13(S)-HODE	Other disease Disease markers Endogenous metabolite	PPAR Mitochondrial Metabolism
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury .

3-Hydroxycoumarin	Structural Classification other families Classification of Application Fields Source classification Other Diseases Coumarins Phenylpropanoids Plants Disease Research Fields	Lipoxygenase
3-hydroxycoumarin is a potent and redox inhibitor of human *15-LOX-1*. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage .

Benzoylgomisin O	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	COX
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against *15-LOX, COX-1* and COX-2 enzymes and anti-inflammatory activity .

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74437

	15 Lipoxygenase 2 Protein, Human (sf9) Polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-Lipoxygenase 2 (15-LOX2) is a non-heme iron-containing dioxygenase crucial for peroxidation of polyunsaturated fatty acids (PUFAs). It exhibits peroxidase activity on arachidonate and linoleate, producing bioactive lipid mediators. Oxygenating arachidonyl derivatives, it generates 15-HETE-G, a peroxisome proliferator-activated receptor alpha agonist. 15-LOX2 class-switches pro-inflammatory mediators, participates in DHA oxidations to produce specialized pro-resolving mediators, and may influence cell cycle progression, proliferation, cytokine secretion, and macrophage differentiation. Importantly, it shows substrate specificity by not converting arachidonic acid to (15S)-HPETE. 15 Lipoxygenase 2 Protein, Human (sf9) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of 15 Lipoxygenase 2 Protein, Human (sf9) is 676 a.a., with molecular weight of 62-66 kDa.

HY-P74436

	15 Lipoxygenase 2 Protein, Human (sf9, His-GST) Polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-lipoxygenase 2 (15-LOX2) is a nonheme iron-containing dioxygenase essential for the peroxidation of polyunsaturated fatty acids (PUFA). It exhibits peroxidase activity towards arachidonic acid and linoleic acid, producing bioactive lipid mediators. 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) is 676 a.a., with molecular weight of ~93 kDa.

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Cat. No.	Product Name		Classification

HY-173115

15-LOX-IN-2		Alkynes
15-LOX-IN-2 (Compound 2a) is an orally active *COX-2/15-LOX* inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .

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15-LOX

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