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Results for "

3-hydroxy-3-methylglutaryl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA synthetase (1) Antibiotic (1) Apoptosis (1) ATF6 (1) Autophagy (3) Biochemical Assay Reagents (1) CD38 (1) CFTR (2) Cholecystokinin Receptor (1) Cytochrome P450 (1) Drug Metabolite (3) Endogenous Metabolite (5) Ferroportin (1) Ferroptosis (2) Fungal (1) HMG-CoA Reductase (HMGCR) (13) Isotope-Labeled Compounds (2) LXR (1) MMP (1) Parasite (1) Phospholipase (1) Vasopressin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (4) Infection (4) Inflammation/Immunology (10) Metabolic Disease (21)

By Targets:

Acetyl-CoA synthetase (1)

Antibiotic (1)

Apoptosis (1)

ATF6 (1)

Autophagy (3)

Biochemical Assay Reagents (1)

CD38 (1)

CFTR (2)

Cholecystokinin Receptor (1)

Cytochrome P450 (1)

Drug Metabolite (3)

Endogenous Metabolite (5)

Ferroportin (1)

Ferroptosis (2)

Fungal (1)

HMG-CoA Reductase (HMGCR) (13)

Isotope-Labeled Compounds (2)

LXR (1)

MMP (1)

Parasite (1)

Phospholipase (1)

Vasopressin Receptor (1)

Virus Protease (1)

By Research Areas:

Cancer (4)

Infection (4)

Inflammation/Immunology (10)

Metabolic Disease (21)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114294A

*DL-3-Hydroxy-3-methylglutaryl* coenzyme A disodium hydrate** HMG-CoA disodium hydrate	Biochemical Assay Reagents	Metabolic Disease
DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .

HY-101873

Atorvastatin lactone	HMG-CoA Reductase (HMGCR)	Metabolic Disease Inflammation/Immunology
Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active *3-hydroxy-3-methylglutaryl* coenzyme A (HMG-CoA)** reductase inhibitor .

HY-135373

Desfluoro-atorvastatin	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Desfluoro-atorvastatin is an impurity of Atorvastatin . Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .

HY-139951S

3-Hydroxy-3-methylglutaryl-Coenzyme A-d3 ammonium	Isotope-Labeled Compounds	Others
3-Hydroxy-3-methylglutaryl-Coenzyme A-d₃ (ammonium) is the deuterium labeled 3-Hydroxy-3-methylglutaryl-Coenzyme A ammonium[1].

HY-W712674

HMG-CoA 3-hydroxy-3-methylglutaryl-CoA	Acetyl-CoA synthetase	Metabolic Disease
HMG-CoA is a product generated by the hydration reaction of (E)-3-methylglutaconyl-CoA (MG-CoA) catalyzed by methylglutaconyl-CoA hydratase (MGCH) .

HY-101873S

Atorvastatin lactone-d5	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR)	Metabolic Disease Inflammation/Immunology
Atorvastatin lactone-d₅ is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

HY-N15097

Dihydrocompactin	Antibiotic Fungal HMG-CoA Reductase (HMGCR)	Infection Inflammation/Immunology
Dihydrocompactin, an antifungal metabolite, is an inhibitor of *3-hydroxy-3-methylglutaryl* coenzyme-A reductase (HMG-CoA reductase)** from Penicillium citrinum .

HY-117581

L-669,262 6-Oxo Simvastatin; Iso-simvastatin-6-one	HMG-CoA Reductase (HMGCR)	Metabolic Disease
L-669,262, a potent inhibitor of *3-hydroxy-3-methylglutaryl* coenzyme A (HMG-CoA) reductase, with an IC₅₀** of 0.10 ng/mL for rat liver HMG-CoA .

HY-135375

*O-Methyl* Atorvastatin calcium**	Drug Metabolite	Metabolic Disease Inflammation/Immunology
O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .

HY-101873R

Atorvastatin lactone (Standard)	HMG-CoA Reductase (HMGCR)	Metabolic Disease Inflammation/Immunology
Atorvastatin lactone (Standard) is the analytical standard of Atorvastatin lactone. This product is intended for research and analytical applications. Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active *3-hydroxy-3-methylglutaryl* coenzyme A (HMG-CoA)** reductase inhibitor .

HY-113410

3-Methylglutaric acid	Endogenous Metabolite	Metabolic Disease
3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH) .

HY-117780

Rawsonol	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Rawsonol is a brominated diphenylmethane derivative obtained from the green alga Avrainuika rawsoni. Rawsonol exhibits inhibitory activity against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with activities related to cholesterol biosynthesis inhibition or other metabolic pathways involving HMG-CoA reductase activity .

HY-17379

Atorvastatin hemicalcium salt 40+ Cited Publications CI-981; Atorvastatin hemicalcium	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Atorvastatin hemicalcium salt (CI-981) is an orally active *3-hydroxy-3-methylglutaryl* coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC₅₀**s of 0.39 μM and 2.39 μM, respectively .

HY-113410R

3-Methylglutaric acid (Standard)	Endogenous Metabolite	Metabolic Disease
3-Methylglutaric acid (Standard) is the analytical standard of 3-Methylglutaric acid. This product is intended for research and analytical applications. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[1][2].

HY-113410S

3-Methylglutaric acid-d4	Endogenous Metabolite	Metabolic Disease
3-Methylglutaric acid-d₄ is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].

HY-17379R

Atorvastatin (hemicalcium salt) (Standard) CI-981 (Standard); Atorvastatin hemicalcium (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Atorvastatin (hemicalcium salt) (Standard) is the analytical standard of Atorvastatin (hemicalcium salt). This product is intended for research and analytical applications. Atorvastatin hemicalcium salt (CI-981) is an orally active *3-hydroxy-3-methylglutaryl* coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC₅₀**s of 0.39 μM and 2.39 μM, respectively .

HY-113725

L 668411	HMG-CoA Reductase (HMGCR)	Others
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.

HY-W414823

24,25-Epoxycholesterol	LXR HMG-CoA Reductase (HMGCR)	Metabolic Disease
24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor that can inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in liver cells. 24,25-Epoxycholesterol regulates cholesterol metabolism in the liver .

HY-100793

SR12813 5 Publications Verification GW 485801	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease
SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC₅₀ value of 0.85 μM . SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) .

HY-129149

Ganoderic acid SZ	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .

HY-19671

Apomine SR-45023A; SR 9223i; SK&F-99085	Apoptosis	Cancer
Apomine (SR-45023A) is an antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. In addition, Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer .

HY-N13366

3-Methylcrotonyl CoA	Drug Metabolite	Metabolic Disease
3-Methylcrotonyl CoA is a key metabolic intermediate in the leucine degradation pathway, converted to 3-Methylglutaconyl CoA by 3-Methylcrotonyl CoA Carboxylase. Normally, 3-Methylglutaconyl CoA is catalyzed by 3-Methylglutaconyl-CoA Hydratase into 3-Hydroxy-3-methylglutaryl-CoA (HMG CoA). However, mutations in 3-Methylglutaconyl-CoA Hydratase lead to the accumulation of 3-Methylglutaconyl CoA, causing metabolic disorders associated with 3MGA-uria. 3-Methylcrotonyl CoA is useful for research into metabolic diseases related to the leucine degradation pathway .

HY-117219

SKF 104976	Cytochrome P450 HMG-CoA Reductase (HMGCR) Endogenous Metabolite	Metabolic Disease
SKF 104976 is a 3,2-carboxylic acid derivative with potent 14-alpha-demethylase (14 alpha DM) inhibitory activity. SKF 104976 inhibited 14 alpha DM activity by 50% at 2 nM in Hep G2 cell extracts. SKF 104976 inhibited the incorporation of [14C]acetate into cholesterol in intact cells at similar concentrations, accompanied by accumulation of lanosterol, and resulted in a 40-70% decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity. SKF 104976 did not affect the uptake and degradation of low-density lipoprotein in Hep G2 cells, indicating that HMGR and low-density lipoprotein receptor activities are not coordinately regulated under these conditions. The inhibitory effect of SKF 104976 on HMGR activity remained unchanged even when the flux of carbon units in the sterol synthesis pathway was reduced by 80%. SKF 104976 did not inhibit HMGR activity under conditions where sterol synthesis was almost completely blocked by lovastatin .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-P4521

*Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt*	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Type