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Results for "

4′‐BR

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

2

Peptides

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124113
    4'-Bromo-resveratrol

    4′‐BR

    		 Sirtuin Apoptosis Cancer
    4'-Bromo-resveratrol is a potent and dual inhibitor Sirtuin-1 and Sirtuin-3. 4'-Bromo-resveratrol inhibits melanoma cell growth through mitochondrial metabolic reprogramming. 4'-Bromo-resveratrol imparts antiproliferative effects in melanoma cells through a metabolic reprogramming and affecting the cell cycle and apoptosis signaling .
    4'-Bromo-resveratrol
  • HY-W039116
    Thalidomide-4-Br

    		Others Neurological Disease Inflammation/Immunology Cancer
    Thalidomide-4-Br (compound 53) is a compound with a bromodomain. Thalidomide-4-Br can be used in the research of inflammation, tumor and neurology .
    Thalidomide-4-Br
  • HY-130591
    Propargyl-PEG4-Br

    		ADC Linker PROTAC Linkers Cancer
    Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Br
  • HY-121845
    4-Br-Bnlm

    		Others Metabolic Disease
    4-Br-Bnlm is a selective inhibitor of glucose-regulated protein 94 (Grp94) with an EC50 value of 0.96 µM. 4-Br-Bnlm reduces the levels of mutant myocilin proteins as well as wild-type myocilin misfold in cells. 4-Br-Bnlm promotes the clearance of toxic formsof myocilin and reduces myocilin toxicity .
    4-Br-Bnlm
  • HY-W007803
    Boc-NH-C4-Br

    		PROTAC Linkers Cancer
    Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
    Boc-NH-C4-Br
  • HY-W013726
    Fmoc-Phe(4-Br)-OH

    		Amino Acid Derivatives Others
    Fmoc-Phe(4-Br)-OH is a phenylalanine derivative that can be used for compound synthesis .
    Fmoc-Phe(4-Br)-OH
  • HY-130161
    m-PEG4-Br

    		ADC Linker PROTAC Linkers Cancer
    m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency . m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-Br
  • HY-164391
    Pomalidomide-C2-amide-C4-Br

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Pomalidomide-C2-amide-C4-Br is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-C2-amide-C4-Br can be used in the synthesis of PROTACs .
    Pomalidomide-C2-amide-C4-Br
  • HY-W011178
    Boc-Phe(4-Br)-OH

    		Amino Acid Derivatives Others
    Boc-Phe(4-Br)-OH is a phenylalanine derivative .
    Boc-Phe(4-Br)-OH
  • HY-151190
    cis-4-Br-2,5-F2-PCPA

    S1024

    		 Histone Demethylase Cancer
    cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells .
    cis-4-Br-2,5-F2-PCPA
  • HY-144995
    BSJ-02-162

    CDK4/6-IN-11

    		 PROTACs CDK Cancer
    CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader . CDK4/6-IN-11 consists of a thalidomide-based E3 ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717), a target protein ligand (red part) Palbociclib (HY-50767), and a PROTAC linker (black part) Boc-NH-C4-Br (HY-W007803). E3 ligase ligand and linker can form Thalidomide-NH-amido-C4-Br (HY-170307).
    BSJ-02-162
  • HY-138486
    Br-PEG4-acid

    		PROTAC Linkers Cancer
    Br-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Br-PEG4-acid
  • HY-130512
    Br-PEG4-OH

    		PROTAC Linkers Cancer
    Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Br-PEG4-OH
  • HY-138372
    Br-PEG4-THP

    		PROTAC Linkers Cancer
    Br-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Br-PEG4-THP
  • HY-138450
    Br-PEG4-methyl acetate

    		PROTAC Linkers Cancer
    Br-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Br-PEG4-methyl acetate
  • HY-153368
    Zomiradomide

    KT-413

    		 IRAK PROTACs Cancer
    KT-413 (example I-3) is an orally active PROTAC-class IRAK degrader . KT-413 consists of a target protein ligand (red part) PROTAC IRAK4 ligand-5 (HY-168311), an E3 ubiquitin ligase ligand (blue part) Thalidomide-4-Br (HY-W039116), and a PROTAC linker (black part) 2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine (HY-168313). E3 ubiquitin ligase and linker can form Thalidomide-NH-C2-2-azaspiro[3.3]heptane (HY-168312). The active control for the target protein ligand is RSL3-4-Me (HY-169375).
    Zomiradomide

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