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5'-TMPS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Apoptosis (1) Biochemical Assay Reagents (1) Caspase (1) Cholinesterase (ChE) (1) Endogenous Metabolite (1) G-quadruplex (1) HDAC (2) Isotope-Labeled Compounds (1) Kinesin (1) P2Y Receptor (1) Phosphodiesterase (PDE) (1) ROR (3) SARS-CoV (2) Telomerase (1) Thymidylate Synthase (1)
By Research Areas:	Cancer (10) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153890

*NVOC cage-TMP-Halo*	Biochemical Assay Reagents	Others
NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .

HY-117819

TMP920	ROR	Inflammation/Immunology
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC₅₀ of 0.03 μM .

HY-102075A

TMP778	ROR	Inflammation/Immunology
TMP778 is a potent and selevtive RORγt inverse agonist, with an IC₅₀ of 7 nM in FRET assay.

HY-102075B

TMP780	ROR	Inflammation/Immunology
TMP780 is an inverse agonist of RORγt with an IC₅₀ of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders .

HY-18361

TMP195 Maximum Cited Publications 15 Publications Verification	HDAC	Cancer
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with K_is of 59, 60, 26, 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

HY-131821

5'-TMPS Thymidine-5'-O-monophosphorothioate	P2Y Receptor	Others
5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y₆R and an antagonist of P2Y₁₄R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects

HY-124064

TMP-153	Acyltransferase	Metabolic Disease
TMP-153 is an orally active inhibitor of ACAT with an IC₅₀ value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .

HY-170323

4-TM.P	Apoptosis	Cancer
4-TM.P binds to the minor groove of DNA, inhibits proliferation of cancer cell K562 with an IC₅₀ of 25 µM, arrests the cell cycle at G0/G1 phase, and induces apoptosis in cell K562. 4-TM.P can be used in anti-leukemia research .

HY-N12033

4'-Demethylpodophyllotoxone	Others	Cancer
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-137807

Thymidine 5′-monophosphate p-nitrophenyl ester sodium	Endogenous Metabolite	Cancer
Thymidine 5′-monophosphate p-nitrophenyl ester sodium (Compound 2a) is the derivative of thymidine 5'-phosphate (TMP). Thymidine 5′-monophosphate p-nitrophenyl ester sodium is potential as an antitumor prodrug .

HY-18360

TMP269 10+ Cited Publications	HDAC	Cancer
TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC₅₀s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

HY-N2044

Methyl 3,4,5-trimethoxybenzoate	Others	Others
Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents.

HY-162698

JMF4073	Thymidylate Synthase	Cancer
JMF4073 is a thymidylate (TMP) and cytidylate (CMP) kinases inhibitor with IC₅₀s of 0.16 μM and 0.17 μM, respectively. JMF4073 eliminates wild-type (WT)-Bcr-Abl-transformed myeloid cells in vitro and in vivo .

HY-150265

TNH TMP-NVOC linker-Halo	Kinesin	Others
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)) .

HY-139362

Enpp-1-IN-2	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC₅₀ values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe .

HY-N2044S

Methyl 3,4,5-trimethoxybenzoate-d9	Isotope-Labeled Compounds	Others
Methyl 3,4,5-trimethoxybenzoate-d₉ is the deuterium labeled Methyl 3,4,5-trimethoxybenzoate[1]. Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents[2].

HY-108477

TMPyP4 tosylate 5+ Cited Publications TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2 .

Cat. No.	Product Name	Target	Research Area

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2044

Methyl 3,4,5-trimethoxybenzoate	Apocynaceae Structural Classification Natural Products Rauvolfia serpentina Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents.

HY-N12033

4'-Demethylpodophyllotoxone	Structural Classification Source classification Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae	Others
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

Cat. No.	Product Name	Chemical Structure

HY-N2044S

Methyl 3,4,5-trimethoxybenzoate-d9
Methyl 3,4,5-trimethoxybenzoate-d₉ is the deuterium labeled Methyl 3,4,5-trimethoxybenzoate[1]. Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents[2].

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5'-TMPS

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products