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Isoforms Recommended:	5-HT₆ Receptor

Results for "

5-HT6 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (52) Adrenergic Receptor (7) Apoptosis (4) Autophagy (5) Cholinesterase (ChE) (1) Dopamine Receptor (8) Drug Metabolite (1) Endogenous Metabolite (2) HDAC (1) Histamine Receptor (2) Isotope-Labeled Compounds (1) mAChR (4) Mitophagy (4) Monoamine Oxidase (1) P2X Receptor (1) Parasite (1) Phospholipase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Neurological Disease (51)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103110

ST1936 1 Publications Verification	5-HT Receptor Adrenergic Receptor	Neurological Disease
ST1936 is a selective, nanomolar affinity **5-HT₆ receptor agonist with K_i values of 13 nM, 168 nM and 245 nM for human 5-HT₆*, 5-HT₇ and 5-HT_2B receptors, respectively. ST1936 also shows moderate affinity (K_i of 300 nM) for human and rat α2 adrenergic receptor* .

HY-14338A

Idalopirdine hydrochloride Lu AE58054 hydrochloride	5-HT Receptor	Neurological Disease
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective **5-HT6 receptor antagonist with a K_i** value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-103141

SB-258585 hydrochloride	Others	Neurological Disease
SB-258585 is a high affinity ligand for the 5-HT₆ receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT₆ receptors. SB-258585 can be used to label recombinant and natural 5-HT₆ receptor .

HY-155316

5-HT6R antagonist 2	Others	Others
5-HT6R antagonist 2 (compound 29) is a 5-HT6 receptor antagonist .

HY-14336

SB 271046	5-HT Receptor	Neurological Disease
SB 271046 is a potent, selective and orally active **5-HT6 receptor antagonist with a pK_i** of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity .

HY-103110A

ST1936 oxalate	5-HT Receptor Adrenergic Receptor	Neurological Disease
ST1936 oxalate is a selective, nanomolar affinity **5-HT₆ receptor agonist with K_i values of 13 nM, 168 nM and 245 nM for human 5-HT₆*, 5-HT₇ and 5-HT_2B receptors, respectively. ST1936 oxalate also shows moderate affinity (K_i of 300 nM) for human and rat α2 adrenergic receptor* .

HY-119061

SB357134	5-HT Receptor	Neurological Disease
SB-357134 is a potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist. SB-357134 enhances memory and learning and increases seizure threshold in rats .

HY-169114

Goxalapladib	5-HT Receptor Phospholipase	Cardiovascular Disease
Goxalapladib is a **5-HT₆ receptor modulator that blocks lipoprotein-associated phospholipase A2 (Lp-PLA2**) activity. Goxalapladib is promising for research of atherosclerosis-associated cardiovascular diseases .

HY-14338

Idalopirdine Lu AE58054	5-HT Receptor	Neurological Disease
Idalopirdine (Lu AE58054 ) is a potent, selective **5-HT6 receptor antagonist with a K_i** value of 0.83 nM. Idalopirdine may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-U00126

5HT6-ligand-1	5-HT Receptor	Neurological Disease
5HT6-ligand-1 is a potent *5-HT6* receptor ligand with a K_i of 1.43 nM.

HY-146076

5-HT6/5-HT2A receptor ligand-1	5-HT Receptor	Neurological Disease
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual **5-HT₆/5-HT_2A receptor antagonist, with a K_i** of 2 nM and 11 nM, respectively. 5-HT6/5-HT2A receptor ligand-1 has the potential for neurological and psychiatric disorders research .

HY-146077

5-HT6/5-HT2A receptor ligand-2	5-HT Receptor	Neurological Disease
5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual **5-HT₆/5-HT_2A receptor antagonist, with a K_i** of 25 nM and 32 nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties .

HY-14335

Ro 04-6790	5-HT Receptor	Neurological Disease
Ro 04-6790 is a potent, competitive and selective *5-HT₆* receptor antagonist with pK_i values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors .

HY-120239

Ro 63-0563	5-HT Receptor	Neurological Disease
Ro 63-0563 is a potent, competitive and selective *5-HT₆* receptor antagonist with pK_i values ??of 7.83 and 7.91 for rat and human *5-HT₆* receptors, respectively. Ro 63-0563 has no affinity for other receptors .

HY-14335A

Ro 04-6790 di(hydrochloride)	5-HT Receptor	Neurological Disease
Ro 04-6790 dihydrochloride is a potent, competitive and selective *5-HT₆* receptor antagonist with pK_i values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 dihydrochloride has no affinity at other receptors .

HY-103099

SB-399885 hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
SB-399885 hydrochloride is a **5-HT₆ receptor** antagonist.

HY-118836

GSK215083	5-HT Receptor	Others
GSK215083 is a high affinity **5-HT6 receptor** antagonist. GSK215083 can serves as a promising 5-HT6 radioligand candidate by radiolabeled with (11)C via methylation .

HY-105896

SB399885	5-HT Receptor	Neurological Disease
SB399885 is a potent, selective, brain penetrant and orally active **5-HT6 receptor antagonist with pK_i** values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties .

HY-103113

MS 245 oxalate	5-HT Receptor	Neurological Disease
MS 245 oxalate is a potent antagonist of *5-HT₆* receptor with a K_i of 2 nM .

HY-14337

MS 245	5-HT Receptor	Neurological Disease
MS 245 is an antagonist of the *5-HT₆* receptor wih an K_i value of 1.5 nM .

HY-103133

WAY208466 dihydrochloride	5-HT Receptor	Neurological Disease
WAY 208466 dihydrochloride is a potent and selective **5-HT₆ receptor agonist (EC₅₀*=7.3 nM for the human 5-HT₆* receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex . WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects .

HY-14340

WAY-181187 1 Publications Verification SAX-187	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) is a potent and selective full *5-HT6* receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM . WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-W746031

WAY-181187 hydrochloride SAX-187 hydrochloride	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) hydrochloride is a potent and selective full *5-HT6* receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM . WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full *5-HT6* receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-109118A

Masupirdine mesylate SUVN-502 mesylate	5-HT Receptor	Neurological Disease
Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant **5-HT6 receptor antagonist (K_i** of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease .

HY-122612

SB-258585	5-HT Receptor	Neurological Disease
SB-258585 is a selective ligand with high affinity for the 5-HT₆ receptor, with a pK_i value of 8.53 .

HY-14336A

SB 271046 Hydrochloride SB 271046A	5-HT Receptor	Neurological Disease
SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active **5-HT6 receptor antagonist with pK_i** of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC₅₀=0.16 μM) .

HY-21995

BGC20-761	5-HT Receptor Dopamine Receptor	Neurological Disease
BGC20-761 is a selecvtive *5-HT6* and dopamine receptor antagonist (human receptor K_i values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent .

HY-14339

Intepirdine 2 Publications Verification SB-742457; GSK-742457; RVT-101	5-HT Receptor	Neurological Disease
Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.

HY-109118

Masupirdine free base SUVN-502 free base	5-HT Receptor	Neurological Disease
Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant **5-HT6 receptor antagonist (K_i** of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease .

HY-115724

FPPQ	5-HT Receptor	Neurological Disease
FPPQ is a dual-acting 5-HT₃ (K_i = 0.9 nM) and 5-HT₆ (K_i = 3 nM) receptor antagonist with antipsychotic and procognitive properties.

HY-14431A

Cerlapirdine hydrochloride SAM-531 hydrochloride; PF-05212365 hydrochloride	5-HT Receptor	Neurological Disease
Cerlapirdine hydrochloride is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine hydrochloride has the potential for researching the Alzheimer's disease .

HY-103090

NPS ALX Compound 4a	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-103090A

NPS ALX Compound 4a dihydrochloride	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-14431

Cerlapirdine 1 Publications Verification SAM-531; PF-05212365	5-HT Receptor	Neurological Disease
Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has the potential for researching the Alzheimer's disease .

HY-123272

E6801	5-HT Receptor	Neurological Disease
E6801 is a 5-HT6 receptor agonist that improves recognition memory by jointly modulating cholinergic and glutamatergic neurotransmission. E6801 can be used in studies of dementia, depression, obesity, epilepsy, etc .

HY-14559

PRX-07034 hydrochloride	5-HT Receptor	Neurological Disease
PRX-07034 hydrochloride is a highly selective and potent **5-HT6 receptor antagonist with a K_i= 4-8 nM and an IC₅₀** of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility .

HY-120464

PF-05212377 SAM-760	5-HT Receptor	Neurological Disease
PF-05212377 (SAM-760) is an inhibitor for serotonin receptor 5-HT6. PF-05212377 is a substrate for P-gp/non-BCRP human transporter. PF-05212377 exhibits blood brain barrier permeability in non-human primates. PF-05212377 can be used for Alzheimer’s Disease research .

HY-117046

AVN-101	Others	Neurological Disease
AVN-101 free base is a multi-target drug candidate with the potential to inhibit central nervous system (CNS) diseases. AVN-101 free base exhibits high inhibitory activity on 5-HT7 receptors and also has certain activity on 5-HT6, 5-HT2A and 5-HT2C receptors. Due to its anxiolytic and antidepressant activities, AVN-101 free base is also expected to be used in diseases such as general anxiety disorder, depression, schizophrenia and multiple sclerosis .

HY-117046A

AVN-101 hydrochloride	5-HT Receptor Histamine Receptor Adrenergic Receptor	Neurological Disease
AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (K_i of 153 pM), with slightly lesser potency toward *5-HT6, 5-HT2A, and 5HT-2C receptors* (K_i values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (K_i of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis .

HY-101009

Methiothepin maleate Metitepine maleate; Ro-8-6837 maleate	5-HT Receptor	Neurological Disease
Methiothepin maleate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-111491

Methiothepin Metitepine; Ro 8-6837	5-HT Receptor	Neurological Disease
Methiothepin is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-N0049

Nuciferine 5 Publications Verification	Parasite 5-HT Receptor Dopamine Receptor	Neurological Disease
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and *5-HT₆* (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-107836

Methiothepin mesylate Metitepine mesylate; Ro 8-6837 mesylate	5-HT Receptor	Neurological Disease
Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-134807

Indophagolin	P2X Receptor 5-HT Receptor Autophagy	Cancer
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC₅₀=140 nM). Indophagolin antagonizes the purinergic receptor P2X₄ as well as P2X₁ and P2X₃ with IC₅₀s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the G_q-protein-coupled P2Y₄, P2Y₆, and P2Y₁₁ receptors (IC₅₀s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT₆ (IC₅₀=1.0 μM) and a moderate effect on receptors 5-HT_1B, 5-HT_2B, 5-HT_4e, and 5-HT₇ .

HY-14541A

Olanzapine hydrochloride LY170053 hydrochloride	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Cancer
Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine hydrochloride is an atypical antipsychotic .

HY-N0049R

Nuciferine (Standard)	5-HT Receptor Dopamine Receptor	Neurological Disease
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and *5-HT₆* (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-14541

Olanzapine Maximum Cited Publications 8 Publications Verification LY170053	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Cancer
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

HY-101622

5-HT6/7 antagonist 1	5-HT Receptor Dopamine Receptor	Neurological Disease
5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes *5-HT6/7/2A* and D2 receptors, without interacting with M1 receptors and hERG channels.

HY-14541R

Olanzapine (Standard) LY170053 (Standard)	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Cancer
Olanzapine (Standard) is the analytical standard of Olanzapine. This product is intended for research and analytical applications. Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

Cat. No.	Product Name	Target	Research Area

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full *5-HT6* receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0049

Nuciferine 5 Publications Verification	Structural Classification Alkaloids Aporphine Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Parasite 5-HT Receptor Dopamine Receptor
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and *5-HT₆* (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-W015169

5-Methoxytryptamine O-Methylserotonin	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	Drug Metabolite 5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action .

HY-W015169A

5-Methoxytryptamine hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action .

HY-N0049R

Nuciferine (Standard)	Structural Classification Alkaloids other families Source classification Plants	5-HT Receptor Dopamine Receptor
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and *5-HT₆* (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

Cat. No.	Product Name	Chemical Structure

HY-14541S2

Olanzapine-d8

Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

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