2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Masupirdine free base

Masupirdine free base  (Synonyms: SUVN-502 free base)

Cat. No.: HY-109118
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Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease.

For research use only. We do not sell to patients.

Masupirdine free base Chemical Structure

Masupirdine free base Chemical Structure

CAS No. : 701205-60-9

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Masupirdine free base Related Antibodies

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Description

Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].

IC50 & Target[1]

5-HT6 Receptor

2.04 nM (Ki)

Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT02580305Suven Life Sciences Limited
Alzheimer´s Disease
September 2015Phase 2
NCT05397639Suven Life Sciences Limited
Agitation|Alzheimer´s Type Dementia
November 1, 2022Phase 3
NCT03564964Suven Life Sciences Limited
Alzheimer Disease|Dementia|Cognition Disorders
Molecular Weight

478.40

Formula

C21H24BrN3O3S
CAS No.
SMILES

O=S(N1C2=CC=C(OC)C=C2C(CN3CCN(C)CC3)=C1)(C(C=CC=C4)=C4Br)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Masupirdine free base Related Classifications

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Keywords:

Masupirdine701205-60-9SUVN-502SUVN502SUVN 5025-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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