Search Result

Results for "

ACCs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (21) Adrenergic Receptor (1) AMPK (4) Amyloid-β (1) Antibiotic (1) Bacterial (3) Biochemical Assay Reagents (1) E3 Ligase Ligand-Linker Conjugates (1) EAAT (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) Monocarboxylate Transporter (2) PDGFR (1) Phytohormone (1) PPAR (1) PROTACs (2) Proteasome (4) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (1) Trk Receptor (1) TRP Channel (1) VEGFR (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (4) Metabolic Disease (13) Neurological Disease (5)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12942

PF-05175157 2 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

HY-RS00146

ACCS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACCS Human Pre-designed siRNA Set A contains three designed siRNAs for ACCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACCS Human Pre-designed siRNA Set A ACCS Human Pre-designed siRNA Set A

HY-161976

ACC1-IN-2	Acetyl-CoA Carboxylase	Inflammation/Immunology
ACC1-IN-2 (Compound 16) is an *ACC1* inhibitor with an IC₅₀ of 7.3 nM. ACC1-IN-2 can be used in the study of acne .

HY-151931

JA-ACC Jasmonyl-ACC	Phytohormone	Metabolic Disease
JA-ACC (Jasmonyl-ACC) is a derivative of 1-aminocyclopropane-1-carboxylic acid (ACC). ACC is the direct precursor of the plant hormone ethylene. JA-ACC inhibits root growth in Arabidopsis and the inhibition is independent of jasmonic acid (JA) signaling .

HY-169008

*PROTAC ACC* degrader-1**	PROTACs Acetyl-CoA Carboxylase	Infection
PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC₅₀ = 107.8 μg/mL). (Structure Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-10984); Black, linker (HY-W007559) .

HY-16946

CP-610431	Acetyl-CoA Carboxylase	Metabolic Disease
CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits *ACC1* and *ACC2* with IC₅₀s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome .

HY-148684

AMPK activator 10	AMPK	Metabolic Disease
AMPK activator 10 is an orally active, potent AMPK activator with EC₁₅₀ of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect .

HY-147930

ACC1/2-IN-1	Acetyl-CoA Carboxylase	Cancer
ACC1/2-IN-1 (compound 4s) is a potent *ACC1/2* inhibitor with IC₅₀ values of 98.06 and 29.43 nM for ACC1 and ACC2, respectively. ACC1/2-IN-1 can be used for cancer research .

HY-147932

ACC1/2-IN-2	Acetyl-CoA Carboxylase	Cancer
ACC1/2-IN-2 (compound PF-3) is a potent *ACC1/2* inhibitor with IC₅₀ values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research .

HY-147376

hACC2-IN-1	Acetyl-CoA Carboxylase	Metabolic Disease
hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research .

HY-151931S

*JA-ACC-d3* Jasmonyl-ACC-d₃	Isotope-Labeled Compounds	Others
JA-ACC-d₃ is deuterium labeled JA-ACC[1].

HY-16901

Firsocostat Maximum Cited Publications 18 Publications Verification ND-630; GS-0976; NDI-010976	Acetyl-CoA Carboxylase	Metabolic Disease
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively.

HY-107709

MK-4074 4 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀ values of approximately 3 nM.

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .

HY-D0713

7ACC2 5+ Cited Publications	Monocarboxylate Transporter Mitochondrial Metabolism	Cancer
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux .

HY-P99527

Vanutide cridificar ACC-001; PF 05236806	Amyloid-β	Neurological Disease
Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate. Vanutide cridificar can be used for Alzheimer's disease (AD) research .

HY-P10003B

*iso-VQA-ACC* acetate**	Proteasome	Others
iso-VQA-ACC acetate is a substrate for constitutive proteasome .

HY-P10003

iso-VQA-ACC	Proteasome	Cancer
iso-VQA-ACC is a substrate for constitutive proteasome .

HY-P10003A

*iso-VQA-ACC* TFA**	Proteasome	Others
iso-VQA-ACC TFA is a constitutive proteasome substrate .

HY-D0067

7ACC1 5+ Cited Publications DEAC; Coumarin D 1421; D 1421	Monocarboxylate Transporter	Cancer
7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers .

HY-127128

Flestolol sulfate ACC-9089 sulfate	Adrenergic Receptor	Neurological Disease
Flestolol (ACC-9089) sulfate is a competitive, ultra-short-acting beta-adrenergic blocking agent. Flestolol sulfate shows a half-life of approximately 6.5 minutes. Flestolol sulfate has the potential for the research of chest pain .

HY-17641

Olumacostat glasaretil DRM01	Acetyl-CoA Carboxylase	Others
Olumacostat glasaretil (DRM01) is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

HY-P10002

EWFW-ACC	Proteasome	Cancer
EWFW-ACC is the tetrapeptide substrate for the immunoproteasome and has selectivity for the LMP7 subunits .

HY-P10002A

*EWFW-ACC* TFA**	Biochemical Assay Reagents	Others
EWFW-ACC TFA is a specific immunoproteasome substrate that can be used to study immunoproteasome function .

HY-W588256

12-Tridecenoic acid	Endogenous Metabolite Acetyl-CoA Carboxylase	Infection
12-Tridecenoic acid is a metabolite of intestinal flora, which can promote the expression of acetyl-CoA carboxylase α (ACC) and inhibit the expression of carnitine palmitoyltransferase 1A (CPT1A), thereby aggravating hepatic steatosis. 12-Tridecenoic acid aggravates hepatic steatosis by affecting the ACC-CPT1A axis .

HY-E70227

Cathepsin G, human neutrophils CTSH; ACC4; ACC5	Ser/Thr Protease	Inflammation/Immunology
Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation .

HY-16901A

Firsocostat (S enantiomer) ND-630 (S enantiomer); GS-0976 (S enantiomer); NDI-010976 (S enantiomer)	Acetyl-CoA Carboxylase	Others
Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase (ACC) inhibitor.

HY-16943

Moiramide B	Bacterial Acetyl-CoA Carboxylase	Infection
Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of 6 nM. Moiramide B has antibacterial activity .

HY-147004

A-908292	Acetyl-CoA Carboxylase	Metabolic Disease
A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism . A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144701

SABA1	Antibiotic Bacterial	Infection Inflammation/Immunology
SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC₅₀ of 4.0 µM against E. coli ACC .

HY-170931

AMPK activator 16	AMPK Acetyl-CoA Carboxylase	Neurological Disease Metabolic Disease
AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells .

HY-152117

Acetyl-CoA Carboxylase-IN-1	Acetyl-CoA Carboxylase Bacterial	Infection
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity .

HY-101842

ND-646 10+ Cited Publications	Acetyl-CoA Carboxylase	Cancer
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC₅₀s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

HY-100771

PCC0208009	Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease
PCC0208009 is a potent IDO inhibitor with an IC₅₀ value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala .

HY-120904

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

HY-169009

(Rac)-Spirotetramat-enol	Acetyl-CoA Carboxylase	Infection
(Rac)-Spirotetramat-enol (Compound 8) is a ligand of acetyl-CoA carboxylase that can be used to synthesize PROTAC ADC degrader (HY-169008) .

HY-169010

Pomalidomide-CO-C5-Br	E3 Ligase Ligand-Linker Conjugates	Infection
Pomalidomide-CO-C5-Br (Compound 6b) is a conjugated compound of the E3 ligand Pomalidomide and linker. It can be used to synthesize highly effective PROTAC molecules targeting ADC (HY-169008) .

HY-19624

*NVP-ACC789* ACC-789; ZK202650	VEGFR PDGFR	Cancer
NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC₅₀s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.

HY-12741

LDN-212320 5+ Cited Publications LDN-0212320; OSU-0212320	EAAT	Neurological Disease
LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC ^[1]

HY-135981

CMS-121 1 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

HY-102066

Utatrectinib AZD-7451	Trk Receptor	Cancer
Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors .

HY-N10612

Petasin	AMPK PPAR TRP Channel Mitochondrial Metabolism	Metabolic Disease Cancer
Petasin inhibits adipogenesis in cell 3T3-F442A with an IC₅₀ of 0.95 μM. Petasin inhibits the expression of lipid synthesis factors ACC1, FAS and SCD1 by inhibiting transcription factors PPARγ and C/EBPα, as well as targeting TRPA1 and TRPV1 channels . Petasin inhibits mitochondrial complex I, thereby inhibiting tumor growth and metastasis. Petasin activates AMPK signaling pathway, participating in regulation of glucose and lipid metabolism. Petasin is orally active .

HY-153367

FHD-609	PROTACs Epigenetic Reader Domain	Cancer
FHD-609 is a PROTAC degrader and inhibitor of BRD9 (Bromodomain-containing protein 9). FHD-609 targets to ncBAF, can be used for research of wide range of cancers that contain a mutation in a BAF complex subunit. FHD-609 in combination with Telomelysin or INO5401, may play a role in adrenocortical carcinoma (ACC) treatment. (Blue: BRD9 ligand-6 (HY-49393), Black: linker (HY-168309); Pink: (S)-Deoxy-thalidomide-Br (HY-168308) ) .

Cat. No.	Product Name

HY-L917

RNA Binding Library	5,000 compounds
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs. MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.

RNA Binding Library

5,000 compounds

RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs.

MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.

Cat. No.	Product Name

HY-KE7017

Fsp I
MCE Fsp I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Acc16 I，Nsb I.

HY-KE7022

Kpn I
MCE Kpn I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Asp718 I, Acc65 I.

Cat. No.	Product Name	Target	Research Area