ARF

By Targets:	Adenylate Cyclase (1) Apoptosis (2) Histone Methyltransferase (1) Phospholipase (1) Ras (1) Small Interfering RNA (siRNA) (5)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (2)
Oligonucleotides:	Pre-designed siRNA Sets (5) siRNAs (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112473

NAV-2729 5 Publications Verification	Others	Cancer
NAV-2729 is a dual *Arf1/Arf6* activation inhibitor.

HY-P10658

ARF1 (2-17)	Phospholipase	Others
ARF1 (2-17) inhibits both ARF-independent (PLC-β) and ARF-dependent (PLD) pathways. ARF1 (2-17) inhibits GTP-γ-S-stimulated PLD activity, phospholipase C-β (PLC-β), and exocytosis .

HY-P10553

ARF(26–44), cell-permeable	Apoptosis	Cancer
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. As a functional inhibitor of FoxM1, ARF(26–44) cell-permeable shows significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC), significantly increasing tumor cell apoptosis and reducing tumor cell proliferation and angiogenesis. ARF(26–44), cell-permeable can be used in research on tumor therapy .

HY-RS00894

ARF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARF1 Human Pre-designed siRNA Set A ARF1 Human Pre-designed siRNA Set A

HY-RS00895

ARF3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARF3 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARF3 Human Pre-designed siRNA Set A ARF3 Human Pre-designed siRNA Set A

HY-RS00896

ARF4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARF4 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARF4 Human Pre-designed siRNA Set A ARF4 Human Pre-designed siRNA Set A

HY-RS00897

ARF5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARF5 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARF5 Human Pre-designed siRNA Set A ARF5 Human Pre-designed siRNA Set A

HY-RS00898

ARF6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARF6 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARF6 Human Pre-designed siRNA Set A ARF6 Human Pre-designed siRNA Set A

HY-100767

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Adenylate Cyclase	Endocrinology
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies .

HY-164536

SLCB050	Apoptosis	Cancer
SLCB050 is a compound that blocks the interaction between DX2 and *p14/ARF* and has anticancer activity. SLCB050 reduces the viability of human lung cancer cells, especially small cell lung cancer cells, in a *p14/ARF*-dependent manner and induces apoptosis and senescence .

HY-139950

Rasarfin 1 Publications Verification	Ras	Cancer
Rasarfin is a dual Ras and *ARF6* inhibitor .

HY-151461

CHNQD-01255	Others	Cancer
CHNQD-01255 is an orally active *Arf-GEFs* inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy .

HY-111549

Bragsin1	Others	Cancer
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC₅₀ of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity .

HY-111550

Bragsin2 1 Publications Verification	Others	Cancer
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC₅₀ of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells .

HY-119344

MS37452 1 Publications Verification	Histone Methyltransferase	Cancer
MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a K_d of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells .

Cat. No.	Product Name	Type

HY-100767

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Gene Sequencing and Synthesis
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies .

Cat. No.	Product Name	Target	Research Area

HY-P10179

ARF6 (2-13)	Peptides	Inflammation/Immunology
ARF6 (2-13) is a peptide with a sequence of GKVLSKIFGNKE. ARF6 (2-13) is an inhibitor of *ARF6. ARF*6 (2-13) can be used in the research of endotoxemia .

HY-P10658

ARF1 (2-17)	Phospholipase	Others
ARF1 (2-17) inhibits both ARF-independent (PLC-β) and ARF-dependent (PLD) pathways. ARF1 (2-17) inhibits GTP-γ-S-stimulated PLD activity, phospholipase C-β (PLC-β), and exocytosis .

HY-P10553

ARF(26–44), cell-permeable	Apoptosis	Cancer
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. As a functional inhibitor of FoxM1, ARF(26–44) cell-permeable shows significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC), significantly increasing tumor cell apoptosis and reducing tumor cell proliferation and angiogenesis. ARF(26–44), cell-permeable can be used in research on tumor therapy .

HY-P10157

ARF(1-22)	Peptides	Others
ARF(1-22) is potentially capable of intracellular penetration to deliver small molecules, proteins, imaging agents, and pharmaceutical nanocarriers .

HY-P10178

*Myristoylated ARF6 (2-13)*	Peptides	Inflammation/Immunology
Myristoylated ARF6 (2-13) blocks MyD88–ARNO–ARF6–signaling axis by deactivating ARF6 .

HY-P10594

*Myr-Arf1(2–17)*	Peptides	Endocrinology
Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR) .

HY-P10186

*Myristoylated ARF6 (2-13), scrambled*	Peptides	Cardiovascular Disease
Myristoylated ARF6 (2-13), scrambled is a peptide , and is composed of amino acids 2–13 of ARF6 (MyrARF6 2–13) .

Species:	Human (6)
Tag:	His (4) Tag Free (1) Myc (1) GST (2)
Source:	E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P72089

	ARF1 Protein, Human (His-GST, Myc) ADP Ribosylation Factor 1; ADP-ribosylation factor 1; ARF 1; ARF1; ARF1_HUMAN	Human	E. coli
	ARF1 is a small GTPase responsible for coordinating protein transport within the Golgi complex. In its GTP-bound state, ARF1 critically regulates Golgi vesicle budding and uncoating by recruiting coat proteins. ARF1 Protein, Human (His-GST, Myc) is the recombinant human-derived ARF1 protein, expressed by E. coli , with N-10*His, C-Myc, GST labeled tag. The total length of ARF1 Protein, Human (His-GST, Myc) is 180 a.a., with molecular weight of ~55 kDa.

HY-P75502

	ARF5 Protein, Human (His) ADP-ribosylation factor 5; ARF5	Human	E. coli
	ARF5 Protein, Human (His) is the recombinant human-derived ARF5 protein, expressed by E. coli , with N-His labeled tag. The total length of ARF5 Protein, Human (His) is 180 a.a., with molecular weight of ~23 kDa.

HY-P75583

	ARF3 Protein, Human (His) ADP-ribosylation factor 3; ARF3	Human	E. coli
	ARF3 protein, a GTP-binding allosteric activator of cholera toxin, plays a role in protein trafficking and vesicle dynamics in the Golgi apparatus. Beyond toxin activation, ARF3 interacts with PRKCABP, participating in diverse cellular processes. It also associates with PI4KB and NCS1/FREQ at the Golgi complex, emphasizing its role in crucial molecular interactions for cellular functions. ARF3 Protein, Human (His) is the recombinant human-derived ARF3 protein, expressed by E. coli , with N-His labeled tag. The total length of ARF3 Protein, Human (His) is 181 a.a., with molecular weight of ~23 kDa.

HY-P76156

	ARL2BP Protein, Human (His) ADP ribosylation factor like 2 binding protein; BART; BART1; Binder of ARF2 protein 1	Human	E. coli
	The ARL2BP protein cooperates with ARL2 to play a crucial role in the nuclear translocation, retention, and transcriptional activity of STAT3, highlighting its cellular involvement. As a potential effector of ARL2, ARL2BP forms a complex with ARL2, SLC25A6, and ARL3. ARL2BP Protein, Human (His) is the recombinant human-derived ARL2BP protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72785

	CDKN2A Protein, Human Cyclin-dependent kinase inhibitor 2A; CDK4I; MTS-1; p16INK4A	Human	E. coli
	CDKN2A Protein, a potent negative regulator of cell proliferation, forms strong interactions with CDK4 and CDK6, hindering their association with cyclins D and retinoblastoma protein phosphorylation. Acting in a heterodimeric manner, predominantly with CDK6, CDKN2A inhibits cyclin D-CDK4 kinase activity and interacts with ISCO2, contributing to its cell cycle regulatory role. CDKN2A Protein, Human is the recombinant human-derived CDKN2A protein, expressed by E. coli , with tag free. The total length of CDKN2A Protein, Human is 155 a.a., with molecular weight of ~19.12 kDa.

HY-P71660

	ARL2BP Protein, Human (GST) ADP ribosylation factor like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; ARL2BP protein; BART; BART1; Binder of ARF2 protein 1	Human	E. coli
	The ARL2BP protein cooperates with ARL2 to play a crucial role in the nuclear translocation, retention, and transcriptional activity of STAT3, highlighting its cellular involvement. As a potential effector of ARL2, ARL2BP forms a complex with ARL2, SLC25A6, and ARL3. ARL2BP Protein, Human (GST) is the recombinant human-derived ARL2BP protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83271

	ARF6 Antibody (YA3016) ADP ribosylation factor 6; ARF6; Small GTP binding protein	WB, ICC/IF	Human, Mouse, Rat
	ARF6 Antibody (YA3016) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3016), targeting ARF6, with a predicted molecular weight of 20 kDa. ARF6 Antibody (YA3016) can be used for WB, ICC/IF experiment in human, mouse, rat background.

HY-P80992

	CDKN2A/p16INK4a Antibody ARF antibody; CDK4 inhibitor p16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; INK4 antibody; INK4a antibody; Melanoma p16 inhibits CDK4 antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; p16 antibody; p16 INK4a antibody; p16INK4a antibody; p19 antibody; P19ARF antibody; TP16 antibody;	WB, IHC-P	Human
	CDKN2A/p16INK4a Antibody is an unconjugated, approximately 16 kDa, rabbit-derived, anti-CDKN2A/p16INK4a monoclonal antibody. CDKN2A/p16INK4a Antibody can be used for: WB, IHC-P expriments in human background without labeling.

HY-P80615

	CDKN2A/p16INK4a Antibody (YA508) CDK4 inhibitor p16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; Cyclin dependent kinase 4 inhibitor A antibody; Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody; Cyclin Dependent Kinase Inhibitor 2A antibody; Cyclin dependent kinase inhibitor 2A isoform 4 antibody; Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody; Cyclin dependent kinase inhibitor p16 antibody; INK4 antibody; INK4A antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; p14 antibody; p16 antibody; P16INK4 antibody; p16INK4a antibody; p19 antibody; p19ARF antibody; TP16 antibody	WB, IP	Human, Mouse
	CDKN2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to CDKN2A. It can be used for WB,IP assays with tag free, in the background of Human, Mouse.

HY-P83091

	ARF5 Antibody (YA2836) ADP ribosylation factor 5; ARF5	WB, FC	Human, Mouse, Rat
	ARF5 Antibody (YA2836) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2836), targeting ARF5, with a predicted molecular weight of 21 kDa (observed band size: 18 kDa). ARF5 Antibody (YA2836) can be used for WB, FC experiment in human, mouse, rat background.

HY-P81818

	CDKN2A/p14ARF Antibody (YA1563) CDKN2A; CDKN2; MLM; Alternative reading frame （ARF）; Cyclin-dependent kinase inhibitor 2A; P14ARF	WB, ICC/IF, IP, FC	Human
	CDKN2A/p14ARF Antibody (YA1563) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1563), targeting CDKN2A/p14ARF, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). CDKN2A/p14ARF Antibody (YA1563) can be used for WB, ICC/IF, IP, FC experiment in human background.

HY-P82000

	GIT1 Antibody (YA1745) ARF GAP GIT1; CAT 1; CaT1; GIT1	WB, FC	Human, Mouse, Rat
	GIT1 Antibody (YA1745) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1745), targeting GIT1, with a predicted molecular weight of 84 kDa (observed band size: 84 kDa). GIT1 Antibody (YA1745) can be used for WB, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS00894

ARF1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ARF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00895

ARF3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ARF3 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00896

ARF4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ARF4 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00897

ARF5 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ARF5 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00898

ARF6 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ARF6 Human Pre-designed siRNA Set A contains three designed siRNAs for ARF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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