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Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells.

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Bragsin2 Chemical Structure

Bragsin2 Chemical Structure

CAS No. : 342795-08-8

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Based on 1 publication(s) in Google Scholar

Bragsin2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bragsin2

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Description

Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].

IC50 & Target

IC50: 3 μM (BRAG2)[1]
In Vitro

Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1].
Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bragsin2 Related Antibodies
Molecular Weight

289.16

Formula

C11H6F3NO5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=C(C(F)(F)F)OC2=CC=C(OC)C([N+]([O-])=O)=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (345.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4583 mL 17.2915 mL 34.5829 mL
5 mM 0.6917 mL 3.4583 mL 6.9166 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

COA (251 KB) HNMR (109 KB) RP-HPLC (185 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4583 mL 17.2915 mL 34.5829 mL 86.4573 mL
5 mM 0.6917 mL 3.4583 mL 6.9166 mL 17.2915 mL
10 mM 0.3458 mL 1.7291 mL 3.4583 mL 8.6457 mL
15 mM 0.2306 mL 1.1528 mL 2.3055 mL 5.7638 mL
20 mM 0.1729 mL 0.8646 mL 1.7291 mL 4.3229 mL
25 mM 0.1383 mL 0.6917 mL 1.3833 mL 3.4583 mL
30 mM 0.1153 mL 0.5764 mL 1.1528 mL 2.8819 mL
40 mM 0.0865 mL 0.4323 mL 0.8646 mL 2.1614 mL
50 mM 0.0692 mL 0.3458 mL 0.6917 mL 1.7291 mL
60 mM 0.0576 mL 0.2882 mL 0.5764 mL 1.4410 mL
80 mM 0.0432 mL 0.2161 mL 0.4323 mL 1.0807 mL
100 mM 0.0346 mL 0.1729 mL 0.3458 mL 0.8646 mL
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Bragsin2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bragsin2342795-08-8Bragsin 2Bragsin-2OthersInhibitorinhibitorinhibit

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