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Results for "

Biguanide

" in MedChemExpress (MCE) Product Catalog:

27

Inhibitors & Agonists

1

Natural
Products

3

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121006
    Biguanide

    		Mitochondrial Metabolism AMPK Metabolic Disease Cancer
    Biguanide is an orally active antihyperglycemic agent. Biguanide inhibits mitochondrial ATP production, activates the LKB1-AMPK signaling pathway, and damages the energy homeostasis. Biguanide exhibits potential in ameliorating the type 2 diabetes and the insulin-associated cancers .
    Biguanide
  • HY-100938
    m-CPBG hydrochloride

    1-(3-Chlorophenyl)Biguanide hydrochloride

    		 5-HT Receptor Neurological Disease
    m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease .
    m-CPBG hydrochloride
  • HY-W013699
    Chlorhexidine diacetate
    Maximum Cited Publications
    9 Publications Verification

    		 Bacterial Antibiotic Infection Cancer
    Chlorhexidine diacetate is a biguanide disinfectant with rapid bactericidal activity against both Gram-positive and Gram-negative organism. The antibacterial effect of chlorhexidine diacetate is related to its action on the bacterial cell membrane and to precipitation of intracellular contents .
    Chlorhexidine diacetate
  • HY-B0608
    Chlorhexidine (digluconate)
    Maximum Cited Publications
    9 Publications Verification

    		 Bacterial Antibiotic Apoptosis Necroptosis Infection Cancer
    Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis .
    Chlorhexidine (digluconate)
  • HY-125283
    IM176OUT05

    		Mitochondrial Metabolism Metabolic Disease
    IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM .
    IM176OUT05
  • HY-B2099A
    Buformin hydrochloride
    3 Publications Verification

    1-ButylBiguanide hydrochloride

    		 AMPK Cancer
    Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .
    Buformin hydrochloride
  • HY-W129818S
    1-(4-Chlorophenyl)biguanide-d4 hydrochloride

    		Isotope-Labeled Compounds Infection Inflammation/Immunology
    1-(4-Chlorophenyl)biguanide-d4 hydrochloride is the deuterium labeled 1-(4-Chlorophenyl)biguanide hydrochloride[1].
    1-(4-Chlorophenyl)biguanide-d4 hydrochloride
  • HY-116844
    Glymidine

    Glidiazine

    		 Others Metabolic Disease
    Glymidine (Glidiazine) is a hypoglycaemic agent. Glymidine is a lipid soluble sulphapyrimidine derivative. Glymidine appears to stimulate insulin release from pancreas. Glymidine is a possible alternative to the sulphonylureas and biguanides for the research of diabetes mellitus .
    Glymidine
  • HY-W013699R
    Chlorhexidine diacetate (Standard)

    		Bacterial Antibiotic Infection Cancer
    Chlorhexidine (diacetate) (Standard) is the analytical standard of Chlorhexidine (diacetate). This product is intended for research and analytical applications. Chlorhexidine diacetate is a biguanide disinfectant with rapid bactericidal activity against both Gram-positive and Gram-negative organism. The antibacterial effect of chlorhexidine diacetate is related to its action on the bacterial cell membrane and to precipitation of intracellular contents .
    Chlorhexidine diacetate (Standard)
  • HY-B2099
    Buformin

    1-ButylBiguanide

    		 AMPK Metabolic Disease Cancer
    Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .
    Buformin
  • HY-U00120
    Picloxydine

    		Bacterial Infection
    Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity.
    Picloxydine
  • HY-16397A
    Phenformin hydrochloride
    5+ Cited Publications

    PhenethylBiguanide hydrochloride

    		 AMPK Autophagy Cancer
    Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.
    Phenformin hydrochloride
  • HY-16397AR
    Phenformin hydrochloride (Standard)

    		AMPK Autophagy Cancer
    Phenformin (hydrochloride) (Standard) is the analytical standard of Phenformin (hydrochloride). This product is intended for research and analytical applications. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.
    Phenformin hydrochloride (Standard)
  • HY-16397AS
    Phenformin-d5 hydrochloride

    PhenethylBiguanide-d5 hydrochloride

    		 Isotope-Labeled Compounds AMPK Autophagy Cancer
    Phenformin-d5 (hydrochloride) is the deuterium labeled Phenformin hydrochloride. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity[1][2].
    Phenformin-d5 hydrochloride
  • HY-B1474
    Alexidine

    		Fungal Infection Cancer
    Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .
    Alexidine
  • HY-158152
    PROTAC CRBN ligand-2

    		Ligands for E3 Ligase Cancer
    PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC50 of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV .
    PROTAC CRBN ligand-2
  • HY-162782A
    V–C6–Bg-PhCl TFA

    		Antibiotic Bacterial Infection
    V–C6–Bg-PhCl TFA (compound 5e) is a biguanide-vancomycin conjugate. V–C6–Bg-PhCl TFA has broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria .
    V–C6–Bg-PhCl TFA
  • HY-136093B
    Lixumistat

    IM156 free base; HL156A free base; HL271 free base

    		 Mitochondrial Metabolism Cancer
    Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus .
    Lixumistat
  • HY-B0806
    Proguanil
    1 Publications Verification

    		 Parasite Antifolate Infection
    Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil
  • HY-B0806A
    Proguanil hydrochloride

    		Parasite Antifolate Infection
    Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil hydrochloride
  • HY-B0806R
    Proguanil (Standard)

    		Parasite Antifolate Infection
    Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil (Standard)
  • HY-B2099S
    Buformin-d9 hydrochloride

    1-ButylBiguanide-d9 hydrochloride

    		 Isotope-Labeled Compounds AMPK Metabolic Disease Cancer
    Buformin-d9 (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1].
    Buformin-d9 hydrochloride
  • HY-B0608R
    Chlorhexidine (digluconate) (Standard)

    		Bacterial Antibiotic Apoptosis Necroptosis Infection Cancer
    Chlorhexidine (digluconate) (Standard) is the analytical standard of Chlorhexidine (digluconate). This product is intended for research and analytical applications. Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis .
    Chlorhexidine (digluconate) (Standard)
  • HY-158820
    Cosdosiran

    QPI-1007

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?
    Cosdosiran
  • HY-158820A
    Cosdosiran sodium

    QPI-1007 sodium

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?
    Cosdosiran sodium
  • HY-E70364
    IgdE protease

    		Biochemical Assay Reagents Inflammation/Immunology
    IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
    IgdE protease
  • HY-N0930B
    Galegine hydrochloride

    		AMPK Bacterial Infection Metabolic Disease
    Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .
    Galegine hydrochloride

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