CCL-2

By Targets:	CCR (4) Keap1-Nrf2 (1) Liposome (1) PPAR (2) Protease Activated Receptor (PAR) (1) SHP2 (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (1) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Aptamers (2) Pre-designed siRNA Sets (1) Cationic Lipids (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99188

Carlumab 1 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) antibody with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer .

HY-B0673

Pirfenidone Maximum Cited Publications 45 Publications Verification AMR69	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-B0498

Bindarit 10+ Cited Publications AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity .

HY-116247

ST247	PPAR	Metabolic Disease Inflammation/Immunology
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ .

HY-RS02089

CCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL2 Human Pre-designed siRNA Set A CCL2 Human Pre-designed siRNA Set A

HY-121896

DSHN	SHP2	Cancer
DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer .

HY-W104821

Rosolic acid	Keap1-Nrf2	Metabolic Disease
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and IL-1β) and apoptotic markers (CXCL10 and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed .

HY-160552

244cis	Liposome	Others
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .

HY-B0673R

Pirfenidone (Standard)	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (Standard) is the analytical standard of Pirfenidone. This product is intended for research and analytical applications. Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-108554

Q94 hydrochloride	Protease Activated Receptor (PAR)	Others
Q94 hydrochloride, a selective PAR₁ antagonist (IC₅₀=916 nM), can selectively block PAR₁/Gαq interaction and signalling. Q94 hydrochloride blocks PAR₁-mediated increases in both *CCL2* mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced *ERK1/2* and MLC phosphorylation .

HY-N3887

Evoxine Haplophytin B; Haplophytine B	Others	Infection
Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative .

HY-163547

PPAR agonist 5	PPAR	Inflammation/Immunology
PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC₅₀ values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect .

Cat. No.	Product Name	Type

HY-W104821

Rosolic acid	Indicators
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and IL-1β) and apoptotic markers (CXCL10 and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed .

Cat. No.	Product Name	Target	Research Area

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)*	Inhibitory Antibodies	Others
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse/rat/human CCL2/MCP-1.

HY-P99188

Carlumab 1 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) antibody with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0498

Bindarit 10+ Cited Publications AF2838	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Endocrinology Cancer	CCR
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity .

HY-N3887

Evoxine Haplophytin B; Haplophytine B	Structural Classification Alkaloids Other Alkaloids Source classification Rutaceae Plants Haplophyllum acutifolium (DC.) G. Don	Others
Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative .

Species:	Human (4) Mouse (6) Rat (1) Cynomolgus (1) Pig (1)
Tag:	His (10) Tag Free (3) Avi (2)
Source:	HEK293 (6) Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P7764

	*MCP-1/CCL2* Protein, Mouse** 5 Publications Verification rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; CCL2; Scya2	Mouse	E. coli
	MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.

HY-P700034AF

	*Animal-Free MCP-1/CCL2* Protein, Human (His)** 1 Publications Verification C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	E. coli
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. Animal-Free MCP-1/CCL2 Protein, Human (His) is the recombinant human-derived animal-FreeMCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free MCP-1/CCL2 Protein, Human (His) is 76 a.a., with molecular weight of ~9.49 kDa.

HY-P700231AF

	*Animal-Free MCP-1/CCL2* Protein, Pig (His)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Pig	E. coli
	MCP-1/CCL2 protein acts as a ligand for CCR2, inducing chemotactic responses and calcium mobilization. It attracts monocytes and basophils but not neutrophils or eosinophils. Animal-Free MCP-1/CCL2 Protein, Pig (His) is the recombinant pig-derived animal-Free MCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag.

HY-P78488

	*MCP-1/CCL2* Protein, Human (HEK293, His-Avi)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P78173

	*MCP-1/CCL2* Protein, Human (Biotinylated, HEK293, His-Avi)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P7237

	*MCP-1/CCL2* Protein, Human** 2 Publications Verification rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Human	E. coli
	MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.

HY-P7235

	*MCP-1/CCL2* Protein, Mouse (HEK293)** rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.

HY-P7236

	*MCP-1/CCL2* Protein, Rat (HEK293, C-His)** rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Rat	HEK293
	MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.

HY-P72757

	*MCP-1/CCL2* Protein, Mouse (HEK293, His)** C-C motif chemokine ligand 2; GDCF-2; HC11; HSMCR30; MCAF; SCYA2; SMC-CF	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293, His) is a mouse MCP-1/CCL2 expressed by HEK293 with a His tag at the C-terminus.

HY-P700787

	*MCP-1/CCL2* Protein, Cynomolgus (HEK293, His)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Cynomolgus	HEK293
	MCP-1/CCL2 protein activates CCR2 and induces chemotaxis and calcium ion mobilization. It attracts monocytes and basophils, not neutrophils or eosinophils. It also contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. MCP-1/CCL2 exists as a monomer or homodimer and binds to endothelial cells through proteoglycans. It interacts with TNFAIP6 via its Link domain. MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MCP-1/CCL2 protein, expressed by HEK293, with C-His labeled tag. The total length of MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is 76 a.a., with molecular weight of 13-16 kDa.

HY-P74758

	*MCP-1/CCL2* Protein, Mouse (sf9, His)** C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (sf9, His) is a mouse MCP-1/CCL2 expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P76489

	*MCP-1/CCL2* Protein, Mouse (Biotinylated, sf9, His)** C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a biotinylated mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P700164AF

	*Animal-Free MCP-1/CCL2* Protein, Mouse (His)** Monocyte Chemotactic Protein-1; MCP-1; JE	Mouse	E. coli
	The MCP-1/CCL2 protein, as a CCR2 ligand, induces potent chemotactic responses and intracellular calcium mobilization in monocytes and basophils, without affecting neutrophils or eosinophils.It is critical for neuropathic pain and enhances NMDA-mediated synaptic transmission in neurons containing dopamine D1 and D2 receptors, possibly involving MAPK/ERK-dependent GRIN2B/NMDAR2B phosphorylation.Animal-Free MCP-1/CCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMCP-1/CCL2 protein, expressed by E.coli , with N-His labeled tag.

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HY-P81171

	MCP1 Antibody MCP-1/CCL2; C-C motif chemokine 2; CCL 2; CCL2; CCL2_HUMAN; Chemokine (C C motif) ligand 2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF-2; GDCF2; HC11; HSMCR30; HSMCR30; JE; MCAF; MCP 1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); Small inducible cytokine A2; Small inducible cytokine subfamily A (Cys Cys), member 2; Small inducible cytokine subfamily A Cys Cys member 2; Small-inducible cytokine A2; SMC CF; SMC-CF; SMCCF.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat
	MCP1 Antibody is an unconjugated, approximately 11 kDa, rabbit-derived, anti-MCP1 polyclonal antibody. MCP1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, rat, and predicted: mouse, dog, pig, horse, rabbit background without labeling.

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HY-RS02089

CCL2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-148100

Emapticap pegol NOX-E36		Aptamers
Emapticap pegol is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) ^[2] .

HY-148100A

Emapticap pegol sodium NOX-E36 sodium		Aptamers
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) ^[2] .

HY-160552

244cis		Cationic Lipids
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .

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CCL-2

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