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Results for "

CD123

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) CD3 (2) Interleukin Related (3)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)

5

Inhibitors & Agonists

5

Inhibitory Antibodies

8

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Vibecotamab XmAb14045	CD3	Cancer
Vibecotamab (XmAb14045) is a potent bispecific antibody against *CD123* and CD3 that stimulates T cell-mediated targeted killing of CD123-expressing cells. Vibecotamab has antitumor activity and can be used in acute myeloid leukaemia studies .

Pivekimab	Interleukin Related ADC Antibody	Cancer
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .

Talacotuzumab JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, *CD123*-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .

Flotetuzumab MGD006; S80880	CD3	Cancer
Flotetuzumab (MGD006; S80880) is an investigational *CD123/CD3* bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to *CD123* in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .

*Anti-IL-3Ra/CD123* Antibody (SNG-CD123A)** SNG-CD123A	Interleukin Related	Inflammation/Immunology
Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) is a CHO-expressed human antibody that targets *IL-3Ra/CD123. The predicted molecular weight (MW) of Anti-IL-3Ra/CD123* Antibody (SNG-CD123A) is 146.14 kDa. The isotype control for Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Target	Research Area

Vibecotamab XmAb14045	CD3	Cancer
Vibecotamab (XmAb14045) is a potent bispecific antibody against *CD123* and CD3 that stimulates T cell-mediated targeted killing of CD123-expressing cells. Vibecotamab has antitumor activity and can be used in acute myeloid leukaemia studies .

Pivekimab	Interleukin Related ADC Antibody	Cancer
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .

Talacotuzumab JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, *CD123*-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .

Flotetuzumab MGD006; S80880	CD3	Cancer
Flotetuzumab (MGD006; S80880) is an investigational *CD123/CD3* bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to *CD123* in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .

*Anti-IL-3Ra/CD123* Antibody (SNG-CD123A)** SNG-CD123A	Interleukin Related	Inflammation/Immunology
Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) is a CHO-expressed human antibody that targets *IL-3Ra/CD123. The predicted molecular weight (MW) of Anti-IL-3Ra/CD123* Antibody (SNG-CD123A) is 146.14 kDa. The isotype control for Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

CD123

Species:	Human (4) Mouse (2) Cynomolgus (1) Canine (1)
Tag:	His (6) Avi (2) Fc (2)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

	*IL-3R alpha/CD123* Protein, Cynomolgus (HEK293, His)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	Cynomolgus	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation. IL-3R alpha/CD123 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Cynomolgus (HEK293, His) is 285 a.a., with molecular weight of 50-65 kDa.

	*IL-3R alpha/CD123* Protein, Human (HEK293, His)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (HEK293, His) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag.

	*IL-3R alpha/CD123* Protein, Canine (HEK293, His)** IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; CD123 antigen; CD123; hIL3Ra; hIL-3Ra; MGC34174; IL-3 R alpha	Canine	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation.IL-3R alpha/CD123 Protein, Canine (HEK293, His) is the recombinant canine-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag.

	*IL-3R alpha/CD123* Protein, Mouse (HEK293, His)** Interleukin-3 receptor subunit alpha; IL-3R-alpha; IL-3RA; CD123; Sut-1	Mouse	HEK293
	IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation. Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K. This activation leads to cell proliferation and differentiation, mediated by STAT5. IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development. IL-3R alpha/CD123 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-8*His labeled tag.

	*IL-3R alpha/CD123* Protein, Mouse (HEK293, Fc)** Interleukin-3 receptor subunit alpha; IL-3R-alpha; IL-3RA; CD123; Sut-1	Mouse	HEK293
	IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation.Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K.This activation leads to cell proliferation and differentiation, mediated by STAT5.IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development.IL-3R alpha/CD123 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-hFc labeled tag.

	*IL-3R alpha/CD123* Protein, Human (Biotinylated, HEK293, Fc-Avi)** Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunitalpha; IL-3R-alpha; IL-3RA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

	*FITC-Labeled IL-3R alpha/CD123* Protein, Human (HEK293, His)** IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; CD123 antigen; CD123; hIL3Ra; hIL-3Ra; MGC34174; IL-3 R alpha	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. FITC-Labeled IL-3R alpha/CD123 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled IL-3R alpha/CD123 protein, expressed by HEK293 , with His labeled tag.

	*IL-3R alpha/CD123* Protein, Human (Biotinylated, HEK293, His-Avi)** CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) is 287 a.a., with molecular weight of 55-65 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

	CD123 Antibody (YA1458) IL3RA; IL3R; Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123	FC, ELISA	Human
	CD123 Antibody (YA1458) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1458), targeting CD123. CD123 Antibody (YA1458) can be used for FC, ELISA experiment in human background.

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