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Results for "

Caenorhabditis elegans

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Antibiotic (2) Bacterial (4) Beta-lactamase (1) Calcium Channel (1) Cytochrome P450 (1) Fungal (1) Insecticide (3) Isotope-Labeled Compounds (1) NAMPT (1) Parasite (2) Reactive Oxygen Species (2) α-synuclein (1)
By Research Areas:	Cancer (2) Infection (13) Metabolic Disease (2) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16670

Dafadine-A	Cytochrome P450	Infection Cancer
Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Dafadine-A inhibits the mammalian ortholog of DAF-9 (CYP27A1). Dafadine-A does not inhibits DAF-12 and sterol- and oxysterol-metabolizing P450s .

HY-N6978

Ascr#5 Ascaroside C3	Others	Infection
Ascr#5 is a highly conserved ascaroside isolated from Caenorhabditis elegans.

HY-N7082

D-Arabinose	Others	Infection
D-Arabinose, a monosaccharide, shows strong growth inhibition against the Caenorhabditis elegans with an IC₅₀ of 7.5 mM .

HY-137229

Avermectin B1a monosaccharide	Parasite	Infection
Avermectin B1a monosaccharide is a macrolide anthelmintic that can inhibit Caenorhabditis elegans .

HY-142025

Daumone	Others	Infection Metabolic Disease
Daumone is a natural product secreted by Caenorhabditis elegans. Daumone can be used for aging and obesity research and the development of anti-nematode drugs .

HY-114521

5-(4-Methoxyphenyl)oxazole	Parasite	Infection
5-(4'-Methoxyphenyl)-oxazole is a Caenorhabditis elegans hatch and growth inhibitor that isolated from fungal culture broth .

HY-136482

Nemadipine B	Calcium Channel	Others
Nemadipine B is a calcium channel blocker and an EGL-19 antagonist. Nemadipine B induces Egl, Vab and Gro phenotypes in Caenorhabditis elegans .

HY-124902

Valclavam	Antibiotic Fungal Bacterial	Infection
Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans.

HY-N12722

Ophiocordylongiiside A	Insecticide	Others
Ophiocordylongiiside A is a compound found in Polyphilus sieberi. Ophiocordylongiiside A shows activity against the free-living nematode Caenorhabditis elegans .

HY-N6976

Ascr#8	Others	Infection
Ascr#8 is an dauer-inducing ascaroside isolated from Caenorhabditis elegans, synergizes with ascr#2 and ascr#3, and strongly enhances male attraction .

HY-N6974

Ascr#2 Ascaroside C6	Others	Infection
Ascr#2 is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with ascr#3 at low concentration .

HY-N7082S

D-Arabinose-13C5	Isotope-Labeled Compounds Others	Infection
D- Arabinose- ¹³C₅ is ¹³C labeled D- Arabinose. D-Arabinose, a monosaccharide, shows strong growth inhibition against the Caenorhabditis elegans with an IC₅₀ of 7.5 mM .

HY-N8804

Shatavarin IV Asparanin B	Reactive Oxygen Species	Neurological Disease Cancer
Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .

HY-168928

Antibiofilm agent prodrug 1	Bacterial	Infection
Antibiofilm agent prodrug 1 (Compound 5c) exhibits antibacterial activity through inhibition of biofilm formation and iron uptake. Antibiofilm agent prodrug 1 inhibits P. aeruginosa PAO1 with a MIC of 1.07 μM. Antibiofilm agent prodrug 1 exhibits anti-infectious efficacy in C. elegans with improved survival rate .

HY-163613

NS163	α-synuclein	Neurological Disease
NS163 is a α-Synuclein aggregation antagonist. NS163 can be used for study of Parkinson’s disease .

HY-130221

(25S)-Δ7-Dafachronic acid Dafachronic acid A; Δ7-Dafachronic acid	Insecticide	Others
(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans .

HY-155528

O4I4	Others	Others
O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability. O4I4 extends lifespan in Caenorhabditis elegans and Drosophila. O4I4 can be used for regenerative medicine and rejuvenation research .

HY-108062

BLI-489	Beta-lactamase Bacterial	Infection
BLI-489 is a beta-lactamase inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens .

HY-W728085

CPPD-Q	Bacterial Antibiotic Insecticide Reactive Oxygen Species	Infection
CPPD-Q is an antimicrobial agent and insecticide. CPPD-Q has an EC₅₀ of 6.98 mg/L against Vibrio fischeri. At doses of 1 or 10 µg/mL, CPPD-Q exerts its insecticidal effect by inducing the production of reactive oxygen species (ROS) in the intestines of Caenorhabditis elegans .

HY-N13240

Ginseng Extract	Others	Others
Ginseng Extract is a ginseng extract, and its components include: Ginsenosides. Ginseng Extract is an excellent animal nutrition feed additive that can reduce the negative effects of heat stress on animal physiology. Studies have shown that Ginseng Extract can prolong the survival time of Caenorhabditis elegans under heat stress, and its mechanism is related to the upregulation of gene expression of specific heat shock proteins and tight junction proteins. .

HY-170794

ALT-007	Acyltransferase	Metabolic Disease
ALT-007 is an orally effective serine palmitoyltransferase (SPT) inhibitor. SPT is the rate-limiting enzyme for the de novo synthesis of ceramide. In a mouse model of age-related sarcopenia, ALT-007 can effectively restore the muscle mass and function impaired by aging. ALT-007 may enhance protein homeostasis in Caenorhabditis elegans and mouse models of aging and age-related diseases and play the role of a ceramide inhibitor .

HY-N8960

1-Hydroxybisabola-2,10-dien-4-one	Others	Neurological Disease
1-Hydroxybisabola-2,10-dien-4-one is a compound with potential anti-Alzheimer's disease activity. The activity of 1-Hydroxybisabola-2,10-dien-4-one was evaluated in the Caenorhabditis elegans Alzheimer's disease pathological model. 1-Hydroxybisabola-2,10-dien-4-one has a wide range of applications in life science related research .

HY-162269

Nampt activator-5	NAMPT	Neurological Disease
Nampt activator-5 (compound C8) is a potent nicotinamide phosphoribosyltransferase (NAMPT) activator with a K_D value of 6.19 µM. Nampt activator-5 shows a cellular antisenescence effect. Nampt activator-5 promotes the production of NAD ⁺ in the brain and reduces the expression of age-related markers and secretory phenotypes. Nampt activator-5 has the potential for the research of age-related diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6978

Ascr#5 Ascaroside C3	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Others
Ascr#5 is a highly conserved ascaroside isolated from Caenorhabditis elegans.

HY-N7082

D-Arabinose	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Saccharides Monosaccharides	Others
D-Arabinose, a monosaccharide, shows strong growth inhibition against the Caenorhabditis elegans with an IC₅₀ of 7.5 mM .

HY-N6974

Ascr#2 Ascaroside C6	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Others
Ascr#2 is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with ascr#3 at low concentration .

HY-142025

Daumone	Structural Classification Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
Daumone is a natural product secreted by Caenorhabditis elegans. Daumone can be used for aging and obesity research and the development of anti-nematode drugs .

HY-124902

Valclavam	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Fungal Bacterial
Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans.

HY-N12722

Ophiocordylongiiside A	Structural Classification Natural Products Source classification Endogenous metabolite	Insecticide
Ophiocordylongiiside A is a compound found in Polyphilus sieberi. Ophiocordylongiiside A shows activity against the free-living nematode Caenorhabditis elegans .

HY-N6976

Ascr#8	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Others
Ascr#8 is an dauer-inducing ascaroside isolated from Caenorhabditis elegans, synergizes with ascr#2 and ascr#3, and strongly enhances male attraction .

HY-N8804

Shatavarin IV Asparanin B	Structural Classification Natural Products Source classification Plants Asparagaceae Juss.	Reactive Oxygen Species
Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .

HY-N13240

Ginseng Extract	Classification of Application Fields Anti-aging Source classification Plants Disease Research Fields Araliaceae	Others
Ginseng Extract is a ginseng extract, and its components include: Ginsenosides. Ginseng Extract is an excellent animal nutrition feed additive that can reduce the negative effects of heat stress on animal physiology. Studies have shown that Ginseng Extract can prolong the survival time of Caenorhabditis elegans under heat stress, and its mechanism is related to the upregulation of gene expression of specific heat shock proteins and tight junction proteins. .

HY-N8960

1-Hydroxybisabola-2,10-dien-4-one	Structural Classification Natural Products Terpenoids Sesquiterpenes Source classification Piperaceae Plants Piper retrofractum Vahl	Others
1-Hydroxybisabola-2,10-dien-4-one is a compound with potential anti-Alzheimer's disease activity. The activity of 1-Hydroxybisabola-2,10-dien-4-one was evaluated in the Caenorhabditis elegans Alzheimer's disease pathological model. 1-Hydroxybisabola-2,10-dien-4-one has a wide range of applications in life science related research .

Cat. No.	Product Name	Chemical Structure

HY-N7082S

D-Arabinose-13C5
D- Arabinose- ¹³C₅ is ¹³C labeled D- Arabinose. D-Arabinose, a monosaccharide, shows strong growth inhibition against the Caenorhabditis elegans with an IC₅₀ of 7.5 mM .

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Caenorhabditis elegans

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products