Csk

By Targets:	AAK1 (1) Apoptosis (1) Aurora Kinase (1) Bcr-Abl (2) Biochemical Assay Reagents (1) CaMK (1) CDK (2) Cyclin G-associated Kinase (GAK) (1) EGFR (1) Ferroptosis (2) LIM Kinase (LIMK) (2) MAP4K (1) MAPKAPK2 (MK2) (1) PROTAC Linkers (1) PROTACs (3) Salt-inducible Kinase (SIK) (2) Small Interfering RNA (siRNA) (1) Src (4) Tie (1) Toll-like Receptor (TLR) (9) ULK (2) VEGFR (1) Wee1 (1)
By Research Areas:	Cancer (7) Infection (4) Inflammation/Immunology (8) Metabolic Disease (1)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130254

CSK-IN-1 1 Publications Verification	Src	Inflammation/Immunology Cancer
CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) with IC₅₀ values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. CSK-IN-1 shows the ability to increase T cell proliferation induced by T cell receptor signaling .

HY-137345

DB-3-291	PROTACs Toll-like Receptor (TLR)	Cancer
DB-3-291 is potent and selective PROTAC *CSK* degrader, with a K_d of 1 nM (Pink: CSK ligand (HY-131669); Blue: E3 ligase ligand (HY-103597); Black: linker (HY-N2407)) .

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-P1180A

Pam3CSK4 TFA Maximum Cited Publications 11 Publications Verification Pam3Cys-Ser-(Lys)4 TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-122113

PD173952 1 Publications Verification	Src Bcr-Abl Apoptosis Wee1	Cancer
PD173952 is a tyrosine kinases inhibitor with IC₅₀s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and *Csk, respectively. PD173952 is also a potent Myt1* kinase inhibitor with a K_i of 8.1 nM. PD173952 induces apoptosis .

HY-P10527

CSK substrate	Src	Others
CSK substrate is a specific substrate for C-terminal Src kinase (CSK), which binds CSK and downregulates the Src family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

HY-RS03238

CSK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CSK Human Pre-designed siRNA Set A contains three designed siRNAs for CSK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CSK Human Pre-designed siRNA Set A CSK Human Pre-designed siRNA Set A

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

HY-P1405

Pam3CSK4-Biotin Pam3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P1180

Pam3CSK4 Pam3Cys-Ser-(Lys)4	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-118105

RK-20448	Src VEGFR Tie	Infection Cancer
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC₅₀ values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, *Csk, Fyn* and Lyn with IC₅₀ values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764) .

HY-112146

MMG-11 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 µM for Pam₃CSK₄-induced hTLR2/1 and 5.7 µM for Pam₂CSK₄-induced hTLR2/6 responses .

HY-112146A

MMG-11 quarterhydrate 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 µM for Pam₃CSK₄-induced hTLR2/1 and 5.7 µM for Pam₂CSK₄-induced hTLR2/6 responses .

HY-108471

CU-CPT22 5+ Cited Publications	Toll-like Receptor (TLR)	Cancer
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam₃CSK₄) binding to TLR1/2 with a K_i of 0.41 µM. CU-CPT22 blocks Pam₃CSK₄-induced TLR1/2 activation with an IC₅₀ of 0.58 µM .

HY-P1180B

Pam3CSK4 trihydrochloride Pam3Cys-Ser-(Lys)4 trihydrochloride	Biochemical Assay Reagents	Others
Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-130504

Propargyl-PEG1-acid 1 Publications Verification	PROTAC Linkers	Cancer
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15196

TAK-285 2 Publications Verification	EGFR	Cancer
TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC₅₀ of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity . TAK-285 can cross the blood-brain barrier (BBB) .

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Others
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .

HY-148063

DB0614	PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) LIM Kinase (LIMK) ULK	Metabolic Disease
DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))

Cat. No.	Product Name	Type

HY-P1180B

Pam3CSK4 trihydrochloride Pam3Cys-Ser-(Lys)4 trihydrochloride	Biochemical Assay Reagents
Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-P1180A

Pam3CSK4 TFA Maximum Cited Publications 11 Publications Verification Pam3Cys-Ser-(Lys)4 TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-P10527

CSK substrate	Src	Others
CSK substrate is a specific substrate for C-terminal Src kinase (CSK), which binds CSK and downregulates the Src family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

HY-P1405

Pam3CSK4-Biotin Pam3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P1180

Pam3CSK4 Pam3Cys-Ser-(Lys)4	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-P1180B

Pam3CSK4 trihydrochloride Pam3Cys-Ser-(Lys)4 trihydrochloride	Biochemical Assay Reagents	Others
Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Species:	Human (2) Mouse (2)
Tag:	His (2) SUMO (1) Tag Free (1) GST (2)
Source:	Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75322

	CSK Protein, Mouse (sf9) Tyrosine-protein kinase Csk; C-Src kinase; Csk	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with tag free. The total length of CSK Protein, Mouse (sf9) is 450 a.a., with molecular weight of ~46 kDa.

HY-P72956

	CSK Protein, Human (sf9, GST) Tyrosine-protein kinase Csk; C-Src kinase; Csk	Human	Sf9 insect cells
	CSK is a non-receptor tyrosine protein kinase that critically regulates cell growth, differentiation, migration and immune responses by phosphorylating tyrosine residues in the C-terminal tail of Src family kinases (SFK). This induces an inactive conformation through intramolecular interactions with the SH2 domain of SFK. CSK Protein, Human (sf9, GST) is the recombinant human-derived CSK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CSK Protein, Human (sf9, GST) is 450 a.a., with molecular weight of ~66 kDa.

HY-P72957

	CSK Protein, Mouse (sf9, His-GST) Tyrosine-protein kinase Csk; C-Src kinase; Csk	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CSK Protein, Mouse (sf9, His-GST) is 450 a.a., with molecular weight of ~65 kDa.

HY-P700596

	CSNK2A2 Protein, Human (His-SUMO) Casein kinase 2 alpha 1 polypeptide; Casein kinase II alpha 1; Casein kinase II alpha 1 subunit; Casein kinase II alpha subunit; Casein kinase II subunit alpha; CK II alpha; CK II; CK2 alpha; CK2 catalytic subunit alpha; CK2A1; CKII; CKIIalpha; Csk21_HUMAN; CSNK2A1	Human	E. coli
	CSNK2A2 is the catalytic subunit of the serine/threonine protein kinase complex. It regulates important processes such as cell cycle, apoptosis, and transcription, and affects viral infection. During mitosis, CSNK2A2 maintains CDK1 activity and induces cell cycle arrest. In addition, CSNK2A2 phosphorylates p53/TP53 and negatively regulates apoptosis. It widely affects cell signaling, phosphorylated caspases, the apoptotic factor NOL3, and RNA polymerase, among others. CSNK2A2 also regulates Wnt signaling and acts as a kinase for extracellular proteins. CSNK2A2 Protein, Human (His-SUMO) is the recombinant human-derived CSNK2A2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CSNK2A2 Protein, Human (His-SUMO) is 343 a.a., with molecular weight of 56.7 kDa.

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HY-P82997

	CSK Antibody (YA2742) Csk; Tyrosine-protein kinase Csk; C-Src kinase; Protein-tyrosine kinase CYL	WB, IHC-P	Human, Mouse, Rat
	CSK Antibody (YA2742) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2742), targeting CSK, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). CSK Antibody (YA2742) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P82223

	PAG1 Antibody (YA1968) CBP; Csk binding protein; PAG; PAG1	WB, IHC-P, IP, FC	Human, Mouse, Rat
	PAG1 Antibody (YA1968) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1968), targeting PAG1, with a predicted molecular weight of 47 kDa (observed band size: 80 kDa). PAG1 Antibody (YA1968) can be used for WB, IHC-P, IP, FC experiment in human, mouse, rat background.

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HY-130504

Propargyl-PEG1-acid 1 Publications Verification		PROTAC Synthesis Alkynes
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS03238

CSK Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CSK Human Pre-designed siRNA Set A contains three designed siRNAs for CSK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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