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Docosahexaenoic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Autophagy (1) Biochemical Assay Reagents (5) Cytochrome P450 (2) Drug Intermediate (2) Drug Metabolite (5) Endogenous Metabolite (13) Epoxide Hydrolase (1) Fatty Acid Synthase (FASN) (1) Isotope-Labeled Compounds (10) Keap1-Nrf2 (1) Lipoxygenase (2) NF-κB (1) PPAR (6) Reactive Oxygen Species (2) TRP Channel (2)
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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107343

Docosahexaenoic acid ethyl ester Ethyl docosahexaenoate	Others	Neurological Disease Metabolic Disease
Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects .

HY-101541

Docosahexaenoic acid methyl ester Methyl docosahexaenoate; all cis-DHA methyl ester	Others	Neurological Disease
Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

HY-B2167

Docosahexaenoic acid Maximum Cited Publications 28 Publications Verification DHA; Cervonic acid	Endogenous Metabolite	Neurological Disease Cancer
Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

HY-B2167S

Docosahexaenoic acid-d5 DHA-d₅; Cervonic acid-d₅	Endogenous Metabolite	Neurological Disease
Docosahexaenoic acid-d₅ is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

HY-107343R

Docosahexaenoic acid ethyl ester (Standard)	Others	Neurological Disease Metabolic Disease
Docosahexaenoic acid ethyl ester (Standard) is the analytical standard of Docosahexaenoic acid ethyl ester. This product is intended for research and analytical applications. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects .

HY-101541R

Docosahexaenoic acid methyl ester (Standard)	Drug Intermediate	Neurological Disease
Docosahexaenoic acid methyl ester (Standard) is the analytical standard of Docosahexaenoic acid methyl ester. This product is intended for research and analytical applications. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

HY-B2167S2

Docosahexaenoic acid-13C4	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Cancer
Docosahexaenoic acid- ¹³C₄ is ¹³C labeled Docosahexaenoic acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk .

HY-B2167R

Docosahexaenoic acid (Standard)	Endogenous Metabolite	Neurological Disease Cancer
Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC₅₀ for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .

HY-107343S

Docosahexaenoic acid ethyl ester-d5 Ethyl docosahexaenoate-d₅	Isotope-Labeled Compounds	Neurological Disease Metabolic Disease
Docosahexaenoic acid ethyl ester-d₅ is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2].

HY-107343S1

Docosahexaenoic acid ethyl ester-d5-1 Ethyl docosahexaenoate-d₅-1	Isotope-Labeled Compounds	Others
Docosahexaenoic acid ethyl ester-d₅-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2][3].

HY-101541S

Docosahexaenoic acid-d5 methyl ester Methyl docosahexaenoate-d₅; all cis-DHA methyl ester-d₅	Isotope-Labeled Compounds	Neurological Disease
Docosahexaenoic acid-d₅ methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].

HY-101541S1

Docosahexaenoic acid-13C22 methyl ester Methyl docosahexaenoate-¹³C₂₂; all cis-DHA methyl ester-¹³C₂₂	Isotope-Labeled Compounds	Others
Docosahexaenoic acid- ¹³C₂₂ methyl ester is the ¹³C₂₂ labeled Docosahexaenoic acid methyl ester (HY-101541)[1].

HY-130289

(±)4-HDHA 4-Hydroxy Docosahexaenoic acid; (±)4-HDoHE	PPAR	Metabolic Disease Inflammation/Immunology
(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent .

HY-124019

4,5-DiHDPA lactone	PPAR	Neurological Disease
4,5-DiHDPA lactone (5), a derivative of docosahexaenoic acid (DHA), is a PPARγ activator .

HY-130239A

(±)14-HDHA (±)14-HDoHE; 14-hydroxy Docosahexaenoic acid; (±)14-HDoHE	Drug Metabolite	Neurological Disease
(±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .

HY-130550

(±)7(8)-EpDPA	Endogenous Metabolite	Others
(±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450 .

HY-157690

19(S),20(R)-EDP	Others	Others
19(S),20(R)-EDP is an epoxidized metabolite of docosahexaenoic acid (HY-B2167) .

HY-113777

22-HDHA 22-Hydroxy Docosahexaenoic acid; 22-OH DHA	Cytochrome P450	Metabolic Disease
22-HDHA (22-Hydroxy Docosahexaenoic acid) is an oxidation product of docosahexaenoic acid. In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.

HY-134997

*4-Oxo Docosahexaenoic* Acid** 4-oxo DHA	PPAR	Cancer
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of Docosahexaenoic acid (HY-B2167) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC₅₀ values of approximately 8-16 μM.

HY-139232

17(R)-Resolvin D3 17(R)-RvD3	Drug Metabolite	Inflammation/Immunology
17(R)-Resolvin D3 is a metabolite of docosahexaenoic acid (DHA). 17(R)-Resolvin D3 has anti-inflammatory activity .

HY-120178

(±)7(8)-DiHDPA	Others	Cardiovascular Disease
(±)7(8)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)7(8)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .

HY-120442

(±)16(17)-DiHDPA	Others	Cardiovascular Disease
(±)16(17)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)16(17)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .

HY-130238

(±)8-HDHA (±)8-HDoHE; 8-hydroxy Docosahexaenoic acid; (±)8-HDoHE	Endogenous Metabolite	Metabolic Disease
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-130287

(±)16-HDHA (±)16-HDoHE; 16-hydroxy Docosahexaenoic acid; (±)16-HDoHE	Endogenous Metabolite	Metabolic Disease
(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-157690A

19(R),20(S)-EDP	Others	Others
19(R),20(S)-EDP (compound 19(S),20(R)-2a) is an oxylipin and a metabolite of docosahexaenoic acid (HY-B2167) .

HY-130419

(±)13(14)-EpDPA 13,14-EpDPE	Cytochrome P450	Cardiovascular Disease Neurological Disease
(±)13(14)-EpDPA (13,14-EpDPE) is the product of the reaction of cytochrome P-450 epoxygenase with Docosahexaenoic Acid (DHA).(±)13(14)-EpDPA has antihyperalgesic and vasorelaxative activities .

HY-136540

Resolvin D3 RvD3	AMPK Autophagy	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-19886

F 16915	Drug Intermediate	Cardiovascular Disease
F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation .

HY-167579

*4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic* acid**	Biochemical Assay Reagents
4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic acid is a kind of biochemical reagent.

HY-130288

(±)13-HDHA (±)13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±)13-HDoHE	Lipoxygenase	Inflammation/Immunology
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-130286

*10-Hydroxy-4(Z),7(Z),11(E),13(Z),16(Z),19(Z)-docosahexaenoic* acid**	Biochemical Assay Reagents	Metabolic Disease
10-Hydroxy-4(Z),7(Z),11(E),13(Z),16(Z),19(Z)-docosahexaenoic acid is an ester product.

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Endogenous Metabolite	Neurological Disease
Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models .

HY-139408

*17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic* acid** 17-Oxo-DHA; 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA	PPAR Keap1-Nrf2	Metabolic Disease
17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid (17-Oxo-DHA) is a metabolite of lipoxygenase-mediated oxidation of DHA. 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid is a PPARγ agonist and activates a Nrf2 dependent antioxidant reaction .

HY-130239

14(S)-HDHA 14(S)-HDoHE	Drug Metabolite	Neurological Disease
14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .

HY-130239S

14(S)-HDHA-d5 14(S)-HDoHE-d₅	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease
14(S)-HDHA-d₅ (14(S)-HDoHE-d₅) is deuterium labeled 14(S)-HDHA. 14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .

HY-120312

PCTR3	Others	Others
PCTR3 is a Docosahexaenoic acid DHA (HY-B2167) derivative, which acts as a pro-resolving and tissue regeneration lipid mediator .

HY-158623

(±)13(14)-DiHDPA (±)13,14-DiHDPE	Drug Metabolite	Inflammation/Immunology
(±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways .

HY-126041A

(±)10(11)-EpDPA (±)10,11-EDP; (±)10,11-EpDPE; (±)10,11-Epoxy docosapentaenoic acid	Epoxide Hydrolase	Metabolic Disease
(±)10(11)-EpDPA, a docosahexaenoic acid epoxygenase metabolite, acts as a substrate for soluble epoxide hydrolase (sEH) with a K_m value of 5.1 µM for human sEH .

HY-119684

Maresin 2	Others	Inflammation/Immunology
Maresin 2 is an anti-inflammatory and pro-resolving mediator from human macrophages. Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages .

HY-116663

(±)20-HDHA (±)20-HDoHE	Endogenous Metabolite	Neurological Disease
(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .

HY-116429

Maresin 1 2 Publications Verification	Reactive Oxygen Species	Inflammation/Immunology
Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca ²⁺] and secretion. Maresin 1 possesses anti-inflammatory activity .

HY-170676

1,3-Dilinoleoyl-2-docosahexaenoyl glycerol	Biochemical Assay Reagents	Metabolic Disease
1,3-Dilinoleoyl-2-docosahexaenoyl glycerol is a triacylglycerol that contains Linoleic acid (HY-N0729) at the sn-1 and sn-3 positions and Docosahexaenoic acid (HY-B2167) at the sn-2 position.

HY-136540S

Resolvin D3-d5 RvD3-d₅	Isotope-Labeled Compounds	Inflammation/Immunology
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].

HY-120255A

17(S)-HDHA	PPAR	Metabolic Disease
17(S)-HDHA is a pro-resolving mediator (SPM). 17(S)-HDHA slightly activats PPARγ, PPARα and PPARδ .

HY-116429S

Maresin 1-d5	Isotope-Labeled Compounds Reactive Oxygen Species	Inflammation/Immunology
Maresin 1-d₅ is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

HY-142974

1,2-Dioleoyl-3-Docosohexaenoyl-rac-glycerol 1,2-Olein-3-Docosohexaenoin; 18:1/18:1/22:6-TG; C1OO	Endogenous Metabolite	Metabolic Disease
1,2-Dioleoyl-3-docosohexaenoyl-rac-glycerol is a triacylglycerol that contains oleic acid (HY-N1446) at the sn-1 and sn-2 positions and docosahexaenoic acid (HY-B2167) at the sn-3 position. It has been detected in human breast milk.

HY-121636

Resolvin D2 4 Publications Verification RvD2	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC₅₀ = 0.1 nM) and TRPA1 (IC₅₀ = 2 nM) in primary sensory neurons .

HY-125527

Resolvin D1 RvD1	Endogenous Metabolite	Inflammation/Immunology
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-116124

17(S)-HpDHA	Lipoxygenase	Others
17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC₅₀ of approximately 1 μM .

HY-121636S

Resolvin D2-d5 RvD2-d₅	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

Cat. No.	Product Name	Type

HY-167579

*4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic* acid**	Drug Delivery
4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic acid is a kind of biochemical reagent.

HY-120978

Omega-3 arachidonic acid methyl ester

ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester

Drug Delivery

omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.

HY-N7833

Heneicosapentaenoic acid

Drug Delivery

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2167

Docosahexaenoic acid 25+ Cited Publications DHA; Cervonic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models .

HY-116663

(±)20-HDHA (±)20-HDoHE	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .

HY-125527

Resolvin D1 RvD1	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-B2167R

Docosahexaenoic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC₅₀ for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .

HY-130550

(±)7(8)-EpDPA	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450 .

HY-120178

(±)7(8)-DiHDPA	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
(±)7(8)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)7(8)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .

HY-158623

(±)13(14)-DiHDPA (±)13,14-DiHDPE	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Drug Metabolite
(±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways .

HY-125527R

Resolvin D1 (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Resolvin D1 (Standard) is the analytical standard of Resolvin D1. This product is intended for research and analytical applications. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

Cat. No.	Product Name	Chemical Structure

HY-B2167S

Docosahexaenoic acid-d5
Docosahexaenoic acid-d₅ is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

HY-121636S

Resolvin D2-d5
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-B2167S2

Docosahexaenoic acid-13C4
Docosahexaenoic acid- ¹³C₄ is ¹³C labeled Docosahexaenoic acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk .

HY-107343S

Docosahexaenoic acid ethyl ester-d5

Docosahexaenoic acid ethyl ester-d₅ is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2].

HY-107343S1

Docosahexaenoic acid ethyl ester-d5-1

Docosahexaenoic acid ethyl ester-d₅-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2][3].

HY-101541S

Docosahexaenoic acid-d5 methyl ester
Docosahexaenoic acid-d₅ methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].

HY-101541S1

Docosahexaenoic acid-13C22 methyl ester
Docosahexaenoic acid- ¹³C₂₂ methyl ester is the ¹³C₂₂ labeled Docosahexaenoic acid methyl ester (HY-101541)[1].

HY-130239S

14(S)-HDHA-d5
14(S)-HDHA-d₅ (14(S)-HDoHE-d₅) is deuterium labeled 14(S)-HDHA. 14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .

HY-136540S

Resolvin D3-d5
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].

HY-116429S

Maresin 1-d5
Maresin 1-d₅ is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

HY-120255AS

17(S)-HDHA-d5
17(S)-HDHA-d₅ is the deuterium labeled 17(S)-HDHA[1].

HY-125527S

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

Cat. No.	Product Name		Classification

HY-158594

Docosahexaenoic acid alkyne DHA-alkyne; FA 22:8		Alkynes
Docosahexaenoic acid alkyne (FA 22:8) is the ω-alkyne derivative of Docosahexaenoic acid (HY-B2167) .

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