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Results for "

GM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (1) Endogenous Metabolite (1) Glucosidase (1) Glucosylceramide Synthase (GCS) (1) Isotope-Labeled Compounds (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (6) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10511

GM1a Ganglioside oligosaccharide	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses ^[1].

HY-E70050

beta-1,3-Galactosyltransferase (CgtB) GM1-synthase	Endogenous Metabolite	Others
beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase) is an enzyme that required for sialylated lipooligosaccharide (LOS ^SIAL) production, is often used in biochemical studies. beta-1,3-Galactosyltransferase (CgtB) catalyzes the addition of a galactose molecule, which is required for GM1-like LOS ^SIAL structure production ^[1].

HY-N10546

Ganglioside GM1	Others	Neurological Disease
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 ^[1].

HY-N10546A

*Ganglioside GM1* (bovine) (ammonium)**	Others	Neurological Disease
Ganglioside GM1 (bovine) ammonium is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 (bovine) ammonium is a functional tissue receptor for the Cholera Toxin1 ^[1].

HY-W714151

Ganglioside ga1 Gg4cer; Asialoganglioside GM1; Asialo GM1, Gangliotetraosylceramide; Asialo ganglioside GM1a [...]; Ganglio-n-tetraosylceramide; Asialo GM1 ganglioside; Asialoganglioside gt1b	Others	Metabolic Disease
Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.

HY-166127

N-Hexanoyl-biotin-monosialoganglioside GM1	Others	Metabolic Disease
N-Hexanoyl-biotin-monosialoganglioside GM1 is an ester product.

HY-146876S

*C18:0 GM1* Ganglioside-d5 ammonium**	Isotope-Labeled Compounds	Others
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-131931

*Lysoganglioside-GM1* potassium** LysoGM1 potassium	Others	Metabolic Disease
Lysoganglioside-GM1 (potassium) (LysoGM1 (potassium)) is an ester product.

HY-N10512

Gangliotetraose Gg4	Others	Neurological Disease
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca ²⁺ and reduces the level of nuclear Ca ²⁺ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain ^[1] .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Others	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate ^[1].

HY-14829A

Afegostat hydrochloride D-Isofagomine hydrochloride; Isofagomine hydrochloride	Glucosidase	Metabolic Disease
Afegostat hydrochloride (D-Isofagomine hydrochloride) is a potent β-galactosidase inhibitor with activity ameliorating GM1-gangliosidosis and Morquio B disease-associated mutations. Afegostat hydrochloride is able to induce the maturation of mutant β-galactosidase in fibroblasts from patients with GM1-gangliosidosis. Afegostat hydrochloride also promotes the reduction of keratin sulfate and oligosaccharide load in patient cells ^[1].

HY-12744

Genz-123346 free base 3 Publications Verification	Others	Metabolic Disease Cancer
Genz-123346 (free base) is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; inhibits GM1 with IC₅₀ value of 14 nM.

HY-12744A

Genz-123346	Glucosylceramide Synthase (GCS)	Metabolic Disease
Genz-123346 is a potent, orally available glucosylceramide synthase inhibitor. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC₅₀ value of 14 nM ^[1].

HY-P990025

Empasiprubart ARGX-117	Complement System	Inflammation/Immunology
Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models ^[1] .

Cat. No.	Product Name	Type

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Native Proteins
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts ^[1].

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Native Proteins

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10529

*Ganglioside GM1-binding peptides p3*	Peptides	Infection
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of *GM1* ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of *GM1* as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between *GM1* and its ligands ^[1].

Cat. No.	Product Name	Target	Research Area