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Results for "

Gli-1

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

2

Natural
Products

1

Antibodies

4

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18366A
    RU-SKI 43 hydrochloride
    2 Publications Verification

    		 Hedgehog Cancer
    RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity [1].
    RU-SKI 43 hydrochloride
  • HY-122590
    Glabrescione B

    		Gli Cancer
    Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells [1] .
    Glabrescione B
  • HY-13282
    GANT 58
    5+ Cited Publications

    NSC 75503

    		 Gli Cancer
    GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM [1].
    GANT 58
  • HY-13901
    GANT 61
    Maximum Cited Publications
    54 Publications Verification

    NSC 136476

    		 Gli Autophagy Cancer
    GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
    GANT 61
  • HY-RS05472
    GLI1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GLI1 Human Pre-designed siRNA Set A
    GLI1 Human Pre-designed siRNA Set A
  • HY-RS05473
    Gli1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gli1 Mouse Pre-designed siRNA Set A
    Gli1 Mouse Pre-designed siRNA Set A
  • HY-RS05474
    Gli1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gli1 Rat Pre-designed siRNA Set A
    Gli1 Rat Pre-designed siRNA Set A
  • HY-161459
    GLI1-IN-1

    		Apoptosis Hedgehog Gli Cancer
    GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC50=1.3 μM) pathway [1].
    GLI1-IN-1
  • HY-18366
    RU-SKI 43

    		Hedgehog Cancer
    RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity [1].
    RU-SKI 43
  • HY-N8270
    Physalin H

    		Hedgehog Endogenous Metabolite Cancer
    Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively [1].
    Physalin H
  • HY-W111144
    T-1330

    		Hedgehog Cancer
    T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression [1].
    T-1330
  • HY-N2112
    Glaucocalyxin A
    2 Publications Verification

    		 PI3K Akt Apoptosis Cancer
    Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect [1].
    Glaucocalyxin A
  • HY-137567
    Prostaglandin E1 ethanolamide

    		Prostaglandin Receptor Cancer
    Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth [1].
    Prostaglandin E1 ethanolamide
  • HY-122017
    Methoxy-SANT-2

    TC-132

    		 Hedgehog Cancer
    Methoxy-SANT-2 (TC-132) is a potent hedgehog antagonist with an IC50 value of 79.8 nM. Methoxy-SANT-2 inhibits the Gli1 reporter gene expression. Methoxy-SANT-2 has the potential for the research of cancer [1].
    Methoxy-SANT-2
  • HY-107551
    GLI antagonist-1

    		Gli Cancer
    GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner [1].
    GLI antagonist-1
  • HY-143400
    HSP70-IN-3

    		HSP Hedgehog Cancer
    HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 [1].
    HSP70-IN-3
  • HY-147670
    TPB15

    		Hedgehog Smo Gli Apoptosis Cancer
    TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity [1].
    TPB15
  • HY-RS05480
    GLIS1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GLIS1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GLIS1 Human Pre-designed siRNA Set A
    GLIS1 Human Pre-designed siRNA Set A
  • HY-162273
    Antibacterial agent 189

    		Bacterial Smo Gli Infection Cancer
    Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins [1].
    Antibacterial agent 189

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