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Results for "

Gli1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (3) Autophagy (1) Bacterial (1) Endogenous Metabolite (1) Gli (7) Hedgehog (8) HSP (1) PI3K (1) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (4) Smo (2)
By Research Areas:	Cancer (15) Infection (1)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Natural
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Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122590

Glabrescione B	Gli	Cancer
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator *Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA* interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells ^[1] .

HY-13282

GANT 58 5+ Cited Publications NSC 75503	Gli	Cancer
GANT 58 (NSC 75503) is a potent *GLI* antagonist that inhibits GLI1-induced transcription with IC₅₀ of 5 μM ^[1].

HY-13901

GANT 61 Maximum Cited Publications 54 Publications Verification NSC 136476	Gli Autophagy	Cancer
GANT 61 is an inhibitor of *Gli1* and *Gli2* targeting the Hedgehog/GLI pathway.

HY-RS05472

GLI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLI1 Human Pre-designed siRNA Set A GLI1 Human Pre-designed siRNA Set A

HY-RS05473

Gli1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli1 Mouse Pre-designed siRNA Set A Gli1 Mouse Pre-designed siRNA Set A

HY-RS05474

Gli1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli1 Rat Pre-designed siRNA Set A Gli1 Rat Pre-designed siRNA Set A

HY-161459

GLI1-IN-1	Apoptosis Hedgehog Gli	Cancer
GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC₅₀=1.3 μM) pathway ^[1].

HY-N8270

Physalin H	Hedgehog Endogenous Metabolite	Cancer
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively ^[1].

HY-122017

Methoxy-SANT-2 TC-132	Hedgehog	Cancer
Methoxy-SANT-2 (TC-132) is a potent hedgehog antagonist with an IC₅₀ value of 79.8 nM. Methoxy-SANT-2 inhibits the Gli1 reporter gene expression. Methoxy-SANT-2 has the potential for the research of cancer ^[1].

HY-W111144

T-1330	Hedgehog	Cancer
T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression ^[1].

HY-107551

GLI antagonist-1	Gli	Cancer
GLI antagonist-1 is a potent *GLI* antagonist with an IC₅₀ value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner ^[1].

HY-18366A

RU-SKI 43 hydrochloride 2 Publications Verification	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity ^[1].

HY-N2112

Glaucocalyxin A 2 Publications Verification	PI3K Akt Apoptosis	Cancer
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect ^[1].

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity ^[1].

HY-137567

Prostaglandin E1 ethanolamide	Prostaglandin Receptor	Cancer
Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth ^[1].

HY-143400

HSP70-IN-3	HSP Hedgehog	Cancer
HSP70-IN-3 is a potent HSP70 inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 ^[1].

HY-147670

TPB15	Hedgehog Smo Gli Apoptosis	Cancer
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity ^[1].

HY-RS05480

GLIS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLIS1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLIS1 Human Pre-designed siRNA Set A GLIS1 Human Pre-designed siRNA Set A

HY-162273

Antibacterial agent 189	Bacterial Smo Gli	Infection Cancer
Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins ^[1].

Glaucocalyxin A 2 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Diterpenoids Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer	PI3K Akt Apoptosis
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect ^[1].

Physalin H	Structural Classification Cardiacglycosides Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80142

	Gli1 Antibody	WB, IHC-P	Mouse, Rat
	Gli1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 118 kDa, targeting to Gli1. It can be used for WB,IHC-P assays with tag free, in the background of Mouse, Rat.

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GLI1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Gli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Gli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLIS1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GLIS1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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