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Results for "

HCN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCN Channel (13) Drug Metabolite (3) PKA (1) Potassium Channel (2) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (3) Cardiovascular Disease (8) Endocrinology (3) Infection (1) Inflammation/Immunology (1) Neurological Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: HCN Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6789

KT5720 3 Publications Verification	PKA	Neurological Disease Cancer
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

HY-161092A

KIO-301 chloride (hydrochloride)	HCN Channel Potassium Channel	Others
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

HY-RS06046

HCN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN1 Human Pre-designed siRNA Set A HCN1 Human Pre-designed siRNA Set A

HY-RS06047

HCN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN2 Human Pre-designed siRNA Set A HCN2 Human Pre-designed siRNA Set A

HY-RS06048

HCN3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN3 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN3 Human Pre-designed siRNA Set A HCN3 Human Pre-designed siRNA Set A

HY-RS06049

HCN4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN4 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN4 Human Pre-designed siRNA Set A HCN4 Human Pre-designed siRNA Set A

HY-163455

*pan-HCN-IN-1*	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-160209

KIO-301	Others	Cardiovascular Disease
KIO-301 is a photoswitchable HCN channel blocker, and can be used as the vitreous “light switch” molecule that reactivates retinitis pigmentosa .

HY-161092

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .

HY-160505

RO-275	HCN Channel	Neurological Disease
RO-275 (compound 29) is a potent, selective and orally active *HCN1* inhibitor with IC₅₀ values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder .

HY-13422

Zatebradine hydrochloride 1 Publications Verification UL-FS-49; UL-FS-49CL	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of *hyperpolarization-activated cyclic nucleotide-gated (HCN) channels* with an IC₅₀ values 1.96 μM. Zatebradine blocks the slow inward current through human *HCN1, HCN2, HCN3* and HCN4 channels, with IC₅₀ values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively .

HY-13422A

Zatebradine 1 Publications Verification UL-FS-49 free base; UL-FS-49CL free base	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of *hyperpolarization-activated cyclic nucleotide-gated (HCN) channels* with an IC₅₀ value of 1.96 µM. Zatebradine blocks the slow inward current through human *HCN1, HCN2, HCN3* and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-119102

BPU-11	HCN Channel	Inflammation/Immunology
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease .

HY-18940A

Cilobradine hydrochloride DK-AH 269	HCN Channel	Cardiovascular Disease
Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.

HY-101346

ZD7288 Maximum Cited Publications 6 Publications Verification ICI D7288	HCN Channel	Neurological Disease
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker .

HY-131281

Ivabradine impurity 1	Drug Metabolite	Others
Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131282

Ivabradine impurity 2	Drug Metabolite	Others
Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131283

8-Demethyl Ivabradine	Drug Metabolite	Endocrinology
8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-B0162A

Ivabradine hydrochloride 2 Publications Verification	HCN Channel	Cardiovascular Disease Endocrinology Cancer
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162

Ivabradine	HCN Channel	Cardiovascular Disease
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162AR

Ivabradine hydrochloride (Standard)	HCN Channel	Cardiovascular Disease Endocrinology Cancer
Ivabradine (hydrochloride) (Standard) is the analytical standard of Ivabradine (hydrochloride). This product is intended for research and analytical applications. Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162S

Ivabradine-d6	HCN Channel	Cardiovascular Disease
Ivabradine-d₆ is the deuterium labeled Ivabradine[1]. Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[2][3][4][5].

HY-114735

Mandelonitrile benzoate	Others	Infection
Mandelonitrile benzoate is a defensive secretion of millipedes that releases other chemicals during the cyanidation process in addition to hydrocyanic acid (HCN) and benzaldehyde. Several families of millipedes, including Polydesmidae, Paradoxosomatidae, and Euryuridae, have been shown to secrete phenols and guaiaeol, with one Paradoxosomatid also producing ethylbenzoic acid and benzoic acid. In addition, members of the Xystodesmidae family commonly produce three compounds: benzoic acid, mandelonitrile benzoate, and benzoyl cyanide. Benzoyl cyanide has not been previously discovered as a natural product. These additional natural products are discussed as defensive antipredator and antibiotic agents. Benzoyl cyanide appears to have anesthetic properties for some predators. The study provides a preliminary chemotaxonomic basis for distinguishing various taxonomic groups of millipedes.

Cat. No.	Compare	Product Name	Species	Source

HY-P703090

	HCN2 Protein, Human (HEK293) BCNG2	Human	HEK293
	HCN2 Protein, Human (HEK293) is the recombinant human-derived HCN2, expressed by HEK293 , with tag Free labeled tag. The total length of HCN2 Protein, Human (HEK293) is 889 a.a.,

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Cat. No.	Product Name	Chemical Structure

HY-B0162S

Ivabradine-d6
Ivabradine-d₆ is the deuterium labeled Ivabradine[1]. Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[2][3][4][5].

HCN1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HCN3 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HCN4 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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