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Isoforms Recommended:	HDAC10

Results for "

HDAC10

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (2) Apoptosis (14) Autophagy (8) Bcl-2 Family (1) Beta-lactamase (2) CDK (1) HDAC (28) Isotope-Labeled Compounds (1) PI3K (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (28) Cardiovascular Disease (1) Inflammation/Immunology (2)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144779

HDAC10-IN-1	HDAC Autophagy	Cancer
HDAC10-IN-1 (compound 13b) is a potent and highly selective *HDAC10* inhibitor, with an IC₅₀ of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells .

HY-144782A

HDAC10-IN-2 hydrochloride	HDAC Autophagy	Cancer
HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective *HDAC10* inhibitor, with an IC₅₀ of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells .

HY-128763

HDAC-IN-4	HDAC	Cancer
HDAC-IN-4 is a selective *HDAC6* and *HDAC10* inhibitor with pIC₅₀s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity .

HY-B0494

Bufexamac 1 Publications Verification Bufexamic acid	HDAC Aminopeptidase	Inflammation/Immunology Cancer
Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with K_ds of 0.53 µM and 0.22 µM for *HDAC6* and *HDAC10. Bufexamac is a nonsteroida anti-inflammatory* drug .

HY-151590

DKFZ-748	HDAC	Cancer
DKFZ-748 is a selective *HDAC10* inhibitor (pIC₅₀=7.66), and shows anti-tumor activity .

HY-RS06061

HDAC10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HDAC10 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HDAC10 Human Pre-designed siRNA Set A HDAC10 Human Pre-designed siRNA Set A

HY-RS06062

Hdac10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hdac10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac10 Mouse Pre-designed siRNA Set A Hdac10 Mouse Pre-designed siRNA Set A

HY-RS06063

Hdac10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hdac10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hdac10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac10 Rat Pre-designed siRNA Set A Hdac10 Rat Pre-designed siRNA Set A

HY-144782

HDAC10-IN-2	HDAC Autophagy	Cancer
HDAC10-IN-2 (compound 10c) is a potent and highly selective *HDAC10* inhibitor, with an IC₅₀ of 20 nM. HDAC10-IN-2 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells .

HY-B0494R

Bufexamac (Standard)	HDAC Aminopeptidase	Inflammation/Immunology Cancer
Bufexamac (Standard) is the analytical standard of Bufexamac. This product is intended for research and analytical applications. Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with Kds of 0.53 μM and 0.22 μM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug .

HY-13592

HDAC-IN-7 Chidamide impurity	HDAC	Cancer
HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

HY-19754A

CRA-026440 hydrochloride	HDAC Apoptosis	Cancer
CRA-026440 hydrochloride is a potent, broad-spectrum *HDAC* (HDAC) inhibitor. The K_i values against recombinant HDAC isoenzymes *HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10* are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities . CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-109015S

Tucidinostat-d4 Chidamide-d₄; HBI-8000-d₄; CS 055-d₄	Isotope-Labeled Compounds HDAC	Cancer
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-152174

HDAC-IN-52	HDAC	Cancer
HDAC-IN-52 is a pyridine-containing *HDAC* inhibitor, with IC₅₀s of 0.189, 0.227, 0.440 and 0.446 μM for *HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC*-IN-52 can be used for the research of cancer .

HY-163430

HDAC-IN-71	HDAC Apoptosis	Cancer
HDAC-IN-71 (Compound 17q) is a potent *HDAC* inhibitor with IC₅₀ values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research .

HY-18613

CAY10603 5 Publications Verification BML-281	HDAC	Cancer
CAY10603 (BML-281) is a potent and selective *HDAC6* inhibitor, with an IC₅₀ of 2 pM; CAY10603 (BML-281) also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC₅₀s of 271, 252, 0.42, 6851, 90.7 nM.

HY-15433A

Quisinostat dihydrochloride 10+ Cited Publications JNJ-26481585 dihydrochloride	HDAC Apoptosis Autophagy	Cancer
Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC₅₀s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity .

HY-15433

Quisinostat 10+ Cited Publications JNJ-26481585	HDAC Apoptosis Autophagy	Cancer
Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC₅₀ values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity . Quisinostat can induce autophagy in neuroblastoma cells .

HY-13271

Tubastatin A Hydrochloride Maximum Cited Publications 24 Publications Verification Tubastatin A HCl; TSA HCl	Beta-lactamase HDAC Autophagy Apoptosis	Cancer
Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6* inhibitor* with IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits *HDAC10* and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

HY-13271A

Tubastatin A Maximum Cited Publications 24 Publications Verification	Beta-lactamase HDAC Autophagy Apoptosis	Cancer
Tubastatin A is a potent and selective HDAC6* inhibitor* with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits *HDAC10* and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

HY-13522

Fimepinostat 10+ Cited Publications CUDC-907	PI3K HDAC Apoptosis	Cancer
Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II *HDAC* enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-155890

Fimepinostat mesylate CUDC-907 mesylate	PI3K HDAC Apoptosis	Cancer
Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II *HDAC* enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-109015

Tucidinostat 20+ Cited Publications Chidamide; HBI-8000; CS 055	HDAC	Cancer
Tucidinostat (Chidamide) is a potent and orally bioavailable *HDAC* enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC₅₀s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC₅₀s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9 .

HY-147731

HDAC6-IN-9	HDAC	Cancer
HDAC6-IN-9 (compound 12c) is a potent and selective *HDAC6* inhibitor with IC₅₀ values of 11.8, 15.2, 4.2, 139.6, 21.3 nM for HDAC1,HDAC3, HDAC6, HDAC8, HDAC10, respectively. HDAC6-IN-9 shows anti-proliferative activities .

HY-13271B

Tubastatin A TFA TSA TFA	HDAC Autophagy Apoptosis	Cancer
Tubastatin A (TSA) TFA is a potent and selective?HDAC6?inhibitor with?IC₅₀?of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A TFA also inhibits *HDAC10* and metallo-β-lactamase domain-containing protein?2 (MBLAC2).

HY-152173

HDAC-IN-51	HDAC Apoptosis Bcl-2 Family CDK	Cancer
HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC₅₀ values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer .

HY-19754

CRA-026440	HDAC Apoptosis	Cardiovascular Disease Cancer
CRA-026440 is a potent, broad-spectrum *HDAC* inhibitor. The K_i values against recombinant HDAC isoenzymes *HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10* are 4, 14, 11, 15, 7, and 20 nM respectively. CRA-026440 shows antitumor and antiangiogenic activities . CRA-026440 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-110280

MC1742	HDAC Apoptosis	Cancer
MC1742 is a potent *HDAC* inhibitor, with IC₅₀s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC .

HY-163834

HDAC6-IN-47	HDAC	Cancer
HDAC6-IN-47 (Compound S-29b) is inhibitor for *HDAC, which exhibits high affinities to HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10* with K_i of 60, 56, 162, 0.44, 362 and 849 nM, respectively. HDAC6-IN-47 causes tubulin hyperacetylation in MV4-11, inhibits the proliferation of MV4-11 with an EC₅₀ of 0.50 µM. HDAC6-IN-47 can be used in research of leukemia .

HY-152225

MC2625	HDAC Apoptosis	Cancer
MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC₅₀s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction .

HY-152226

MC2590	HDAC Apoptosis	Cancer
MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC₅₀s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC₅₀s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction .

Cat. No.	Compare	Product Name	Species	Source

HY-P703069

	HDAC10 Protein, Human (His) Polyamine deacetylase HDAC10; Histone deacetylase 10; HD10; EC:3.5.1.48; EC:3.5.1.62	Human	E. coli
	HDAC10 Protein, Human (His) is the recombinant human-derived HDAC10, expressed by E. coli , with N-6*His labeled tag. The total length of HDAC10 Protein, Human (His) is 669 a.a.,

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Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

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HY-P80150

	HDAC10 Antibody	WB, ICC/IF, IP	Human
	HDAC10 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to HDAC10. It can be used for WB,ICC,IP assays with tag free, in the background of Human.

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HDAC10 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HDAC10 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac10 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Hdac10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac10 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Hdac10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hdac10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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