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Isoforms Recommended:	HDAC11

Results for "

HDAC11

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (12) Autophagy (6) Bcl-2 Family (1) CDK (1) DNA/RNA Synthesis (2) Filovirus (3) HDAC (21) HPV (3) Mitophagy (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (19) Infection (4) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145757

Elevenostat JB3-22	HDAC	Cancer
Elevenostat (JB3-22) is a selective *HDAC11* inhibitor (IC₅₀=0.235 µM). Anti-multiple myeloma (MM) activity .

HY-114483

AES-135 1 Publications Verification	HDAC	Cancer
AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC₅₀s ranging from 190-1100 nM .

HY-112285

FT895 1 Publications Verification	HDAC	Inflammation/Immunology
FT895 is a potent and selective *HDAC11* inhibitor with an IC₅₀ of 3 nM .

HY-15433A

Quisinostat dihydrochloride 10+ Cited Publications JNJ-26481585 dihydrochloride	HDAC Apoptosis Autophagy	Cancer
Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC₅₀s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity .

HY-18998

LMK-235 15+ Cited Publications	HDAC	Cancer
LMK-235 is a potent and selective *HDAC4/5* inhibitor, inhibits HDAC5, HDAC4, HDAC6, HDAC1, HDAC2, HDAC11 and HDAC8, with IC₅₀s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively, and is used in cancer research.

HY-RS06064

HDAC11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HDAC11 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HDAC11 Human Pre-designed siRNA Set A HDAC11 Human Pre-designed siRNA Set A

HY-RS06065

Hdac11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hdac11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac11 Mouse Pre-designed siRNA Set A Hdac11 Mouse Pre-designed siRNA Set A

HY-RS06066

Hdac11 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hdac11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hdac11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac11 Rat Pre-designed siRNA Set A Hdac11 Rat Pre-designed siRNA Set A

HY-157889

ZINC000028464438	HDAC	Cancer
ZINC000028464438 is a selective *HDAC11* inhibitor with an IC₅₀ of 3.5 µM. ZINC000028464438 shows almost no inhibition for other HDAC subtypes .

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	HDAC	Infection Cancer
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available **HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II)** and Class IV (HDAC11) .

HY-15433

Quisinostat 10+ Cited Publications JNJ-26481585	HDAC Apoptosis Autophagy	Cancer
Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC₅₀ values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity . Quisinostat can induce autophagy in neuroblastoma cells .

HY-149766

PB94	HDAC	Neurological Disease
PB94 is a selective HDAC11 inhibitor (IC₅₀=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications .

HY-12164

Mocetinostat 10+ Cited Publications MGCD0103	HDAC Autophagy Apoptosis	Cancer
Mocetinostat (MGCD0103) is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC₅₀s of 0.15, 0.29, 1.66 and 0.59 μM for *HDAC1, HDAC2, HDAC3* and *HDAC11, respectively. Mocetinostat shows no inhibition on HDAC4, HDAC5, HDAC6, HDAC7, or HDAC*8.

HY-109015

Tucidinostat 20+ Cited Publications Chidamide; HBI-8000; CS 055	HDAC	Cancer
Tucidinostat (Chidamide) is a potent and orally bioavailable *HDAC* enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC₅₀s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC₅₀s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9 .

HY-10221

Vorinostat Maximum Cited Publications 102 Publications Verification SAHA; Suberoylanilide hydroxamic acid	HDAC Autophagy Mitophagy Filovirus Apoptosis HPV	Infection Cancer
Vorinostat (SAHA) is a potent and orally active pan-inhibitor of *HDAC1, HDAC2* and HDAC3 (Class I), *HDAC6* and HDAC7 (Class II) and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

HY-152173

HDAC-IN-51	HDAC Apoptosis Bcl-2 Family CDK	Cancer
HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC₅₀ values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer .

HY-152226

MC2590	HDAC Apoptosis	Cancer
MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC₅₀s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC₅₀s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction .

HY-10221R

Vorinostat (Standard)	HDAC Autophagy Mitophagy Filovirus Apoptosis HPV	Infection Cancer
Vorinostat (Standard) is the analytical standard of Vorinostat. This product is intended for research and analytical applications. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of *HDAC1, HDAC2* and HDAC3 (Class I), *HDAC6* and HDAC7 (Class II) and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

HY-115412

Vorinostat-d5 SAHA-d5; Suberoylanilide hydroxamic acid-d5	HDAC Autophagy Mitophagy Filovirus Apoptosis HPV	Infection Cancer
Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of *HDAC1, HDAC2* and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

HY-110280

MC1742	HDAC Apoptosis	Cancer
MC1742 is a potent *HDAC* inhibitor, with IC₅₀s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC .

HY-128918

SIS17 5+ Cited Publications	HDAC	Cancer
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs .

HY-143412

MIR002	HDAC DNA/RNA Synthesis Apoptosis	Cancer
MIR002 is a potent and orally active DNA polymerase α (POLA1) and *HDAC 11* dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo .

HY-143411

GEM144	HDAC Apoptosis DNA/RNA Synthesis	Cancer
GEM144 is a potent and orally active DNA polymerase α (POLA1) and *HDAC 11* dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts .

HY-152225

MC2625	HDAC Apoptosis	Cancer
MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC₅₀s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction .

Cat. No.	Product Name	Type

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	Fluorescent Dye
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available **HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II)** and Class IV (HDAC11) .

Cat. No.	Product Name	Type

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	Biochemical Assay Reagents
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available **HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II)** and Class IV (HDAC11) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83139

	HDAC11 Antibody (YA2884) HDAC11; HD11; Histone deacetylase 11	WB, IP	Human
	HDAC11 Antibody (YA2884) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2884), targeting HDAC11, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). HDAC11 Antibody (YA2884) can be used for WB, IP experiment in human background.

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HDAC11 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HDAC11 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac11 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Hdac11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac11 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Hdac11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hdac11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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