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Hsp60

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By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (1) HIF/HIF Prolyl-Hydroxylase (1) HSP (5) Influenza Virus (1) Mitochondrial Metabolism (1) Oxidative Phosphorylation (1) Potassium Channel (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1)

6

Inhibitors & Agonists

1

Fluorescent Dye

1

Peptides

2

Natural
Products

3

Recombinant Proteins

3

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Nonactin Ammonium ionophore I	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP	Infection Cancer
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous *HSP60* .

Myrtucommulone A	HSP	Inflammation/Immunology
Myrtucommulone A is a non-prenylated acylphloroglucinol that can be isolated from Myrtus communis (myrtle). Myrtucommulone A interacts with the *HSP60* chaperone and inhibits HSP60 chaperone activity. Myrtucommulone A decreases the expression of LRP130, LONP .

O-Carboranylphenoxyacetanilide	HIF/HIF Prolyl-Hydroxylase HSP	Cancer
O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC₅₀: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity .

[Au(TPP)]Cl	HSP	Cancer
[Au(TPP)]Cl inhibits the refolding activity of the *Hsp60-Hsp10* complex with significant anticancer activities .

ETB	HSP	Cancer
ETB is a potent *Hsp60* chaperone activity inhibitor. ETB blockes the chaperone activities of the wild-type protein and of the C237A and C447A mutant proteins. ETB binds to Hsp60 Cys ⁴⁴² and shows the resistance of the C442A mutant to ETB inhibition .

BF844	Others	Others
BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1) ^N48K. BF844 induces CLRN1 ^N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo .

Cat. No.	Product Name	Type

O-Carboranylphenoxyacetanilide	Fluorescent Dyes/Probes
O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC₅₀: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity .

Cat. No.	Product Name	Target	Research Area

DiaPep277	Peptides	Metabolic Disease Inflammation/Immunology
DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes .

Species:	Human (1) Mouse (2)
Tag:	His (2) GST (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	HSP60 Protein, Mouse (His) 1 Publications Verification 60 kDa heat shock protein, mitochondrial; CPN60; Hsp-60; HspD1	Mouse	E. coli
	The HSP60 protein, together with Hsp10, contributes to the import and assembly of mitochondrial proteins. It ensures correct folding and prevents incorrect folding under stressful conditions. HSP60 Protein, Mouse (His) is the recombinant mouse-derived HSP60 protein, expressed by E. coli , with N-His labeled tag. The total length of HSP60 Protein, Mouse (His) is 572 a.a., with molecular weight of ~58 kDa.

	HSP60 Protein, Human (His-GST) 60 kDa heat shock protein, mitochondrial; CPN60; Hsp-60; HspD1	Human	E. coli
	The HSP60 protein is a mitochondrial chaperone that facilitates protein import and assembly. HSP60 Protein, Human (His-GST) is the recombinant human-derived HSP60 protein, expressed by E. coli , with N-His, N-GST labeled tag.

	HSP60 Protein, Mouse (N-His) 60 kDa heat shock protein, mitochondrial; CPN60; Hsp-60; HspD1	Mouse	E. coli
	The HSP60 protein, together with Hsp10, contributes to the import and assembly of mitochondrial proteins. It ensures correct folding and prevents incorrect folding under stressful conditions. HSP60 Protein, Mouse (N-His) is the recombinant mouse-derived HSP60, expressed by E. coli , with N-10*His labeled tag. The total length of HSP60 Protein, Mouse (N-His) is 572 a.a.,

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Cat. No.	Compare	Product Name	Application	Reactivity

	HSP60 Antibody	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	HSP60 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to HSP60. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

	Hsp60 Antibody (YA730) HspD1; Hsp60; 60 kDa heat shock protein; mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; Hsp-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein	WB, ICC/IF, IP	Human, Mouse, Rat
	Hsp60 Antibody (YA730) is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to Hsp60 (6C8). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

	HspA14 Antibody (YA3003) HspA14; Hsp60; Hsp70L1; Heat shock 70 kDa protein 14; Hsp70-like protein 1; Heat shock protein Hsp60	WB, ICC/IF, IP	Human, Mouse
	HspA14 Antibody (YA3003) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3003), targeting HspA14, with a predicted molecular weight of 55 kDa (observed band size: 55 kDa). HspA14 Antibody (YA3003) can be used for WB, ICC/IF, IP experiment in human, mouse background.

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